NovAseptic Valves.

Aseptic by design.
A superior design for aseptic point of use
NovAseptic® Valves.
Aseptic by design.
NovAseptic® Valves are engineered for optimal performance, The main features of NovAseptic® Valves that
give them their fine reputation include:
reliability, durability and ease of maintenance.
• CIP/SIP — Compatible
The design and development of each component is based on • No dead leg — No risk of contamination
more than 20 years’ experience, focused on aseptic design. • Low product hold-up — Saves money
NovAseptic® Valves comply with cGMP Design Qualification
• T otally drainable — Excellent aseptic
criteria for aseptic processing. performance

This is why we choose to call it ‘‘Aseptic by Design.” • Engineering flexibility

Process Valves
NovAseptic® Valves are specifically designed for aseptic applications and comply
with the most stringent cleanability and sterilizability requirements. The focus on
aseptic design is a significant feature for all valves.
Take off valves are often the ultimate choice when it is necessary to integrate taps
designed for aseptic distribution systems for purified water (PW) and water for
injection (WFI).
Shut Off Valve
Tank Outlet Valves The diaphragm seal system on the NovAseptic®
Valve produces positive sealing with no cavities. The
NovAseptic® Tank Outlet Valves are particularly designed to comply with the most seal remains static regardless of the position of the
rigorous requirements in applications in which CIP/SIP is crucial. Their integration diaphragm. The valve is totally drainable and clean-
in aseptic processing equipment ensures that this important part of the system able. 90° or 180° shut-off valves give engineers full
can be easily sterilized and cleaned in place. flexibility with full drainability and low pressure drop.

Actuators and Diaphragms

Choose from a wide range of diaphragms and
the following actuators for your applications:
• Pneumatic Actuators
– Spring Closed/Open
– Multiple Acting
• Manual Actuators
– Standard The diaphragm is sealed by an O-ring integrated in
– Angled Extended Axis the diaphragm which fits into the corresponding
groove in the valve body. The actuator exerts
positive pressure on this single seal, which remains
Cost Effective, Custom Designed Solutions static regardless of the position of the diaphragm.
The different valves and valve combinations in sizes from 12 to 76 mm provide
a wide range of solutions to engineering challenges. Solutions that give you full
flexibility. Aseptic valves and combinations that provide a process with no dead Drainage Point
legs and full CIP/SIP. The aseptic design makes the process easier to validate, with
diaphragm materials such as Fluorocarbon Elastomer, EPDM, Silicone and PTFE. A valve combination that offers a
These fulfill FDA criteria and are USP Class VI tested. With our know-how in the dead leg free drainage point with
application of automated processes, we can help you choose the best aseptic separate outlets for steam trap
solutions for your applications. and drainage, secured with double
diaphragms between the product
line and drainage/steam trap.
Innovatively Designed Aseptic Components

Take Off Valve

This valve has been specially
designed for taps involved
in the aseptic distribution of
purified water (PW) and water
for injection (WFI). Totally
dead leg free and without any
pressure drop over the valve in
the main pipe.
Flow Through Valve
A valve designed for a wide range of
applications in the aseptic process;
including manifolds, take off and
drainage valves.

Tank Outlet Valve

When welded in place, the valve
becomes an integrated part of the
tank base. It is engineered in the
same way all NovAseptic® Valves
are and can be equipped with
different outlet elbows and con-
nectors. A CIP/SIP valve can also
Divert Valve be welded on the tank outlet valve
The divert valve can be used in various to ensure clean/sterile downstream
applications where the need for a minimum piping before starting to empty the
dead leg between two valves is important. tank. The tank outlet valve is avail-
able from 12 mm up to 76 mm.
 Production and Quality Control
Starting from Zero
The different market requirements for material quality standards outstanding result. The valve part is polished manually and, if required,
according to ASME®, ASTM® and various European specifications are electro-polished according to your requirements to a surface finish of
allready taken into account when the stainless steel is ordered from the Ra < 0.5 µm, or better.
steelworks.
Our quality control program for the valve body is extensive and ensures
The material is cut from the original bar into work-pieces before being that only high-quality products are shipped to our customers.
used to produce valve bodies. The heat number from the original bar is
transferred directly to the valve body or recorded with the batch numbers Quality Control Benefits
that are engraved on the valve body. This provides full traceability back to
the mill certificate for each single unit. • Uniform and high quality
• 3.1 certificate available on all wetted parts
Computerized, Uniform Handling • Smooth inner surface — Easy cleaning
The bodies are turned in computer-programmed turning lathes to their • Documentation for easy validation
final shape and the pipes are welded using semi-automatic TIG welding
on the outside. This operation guarantees uniform handling and an • Diaphragm according to FDA and USP Class VI tested

A Wide Range of Applications

Our clients currently include many of the world’s top companies in the pharmaceutical, biotech and food industries — located throughout Europe,
the United States and Asia. Our Sales constitute an international force, able to solve problems related to aseptic processes using innovative technical
solutions. NovAseptic® Valves are chosen for a wide range of different applications in processes of different types.

WFI and PW Filling Machines

The NovAseptic® Valve is often used as a take off valve in WFI and NovAseptic® Valves are used in many different types of filling equipment
PW systems due to its superior design. This design enables a tap point in both the pharmaceutical and the food industries, to ensure aseptic
without any dead leg and without pressure drop in the main loop with conditions from storage tank to packing.
the opportunity to CIP/SIP the downstream pipe from the tap valve to the
point of use. Feedback from End Users
End users often mention the same features when it comes to
Injection Solutions
NovAseptic® Valves, namely:
Processes for manufacturing injection solutions are critical applications • Low hold-up volumes and no dead legs that result in a high
for which many companies use NovAseptic® Tank Outlet Valves and
Process Valves as their first choice. recovery rate for expensive/valuable products
• Compact sizes which are important for engineering flexibility
Fermentations • Low pressure drops
NovAseptic® Valves are used in many fermentation applications, in both • Potential for customized solutions
the pharmaceutical and food industries. • Easy handling

Vaccines
Entire production facilities for vaccines are built using NovAseptic®
Valves. Important features that are taken into consideration include low
hold-up volumes and CIP/SIP.

To Place an Order or Receive

Technical Assistance
In the U.S. and Canada, call toll-free
1(800)-645-5476
For other countries across Europe, call
www.merckmillipore.com /offices +44 (0) 115 943 0840
For other countries across Europe and the world,
Merck Millipore and the M logo are trademarks of Merck KGaA, Darmstadt, Germany.
NovAseptic® is a registered trademark of Merck KGaA, Darmstadt, Germany. please visit www.merckmillipore.com/offices
ASME is a registered trademark of the American Society of Mechanical Engineers.
ASTM is a registered trademark of the American Society for Testing and Materials. For Technical Service, please visit
Lit. No. PB1002EU00 Rev. A PS SBU-12-06913 7/2011
© 2012 EMD Millipore Corporation, Billerica, MA 01821 U.S.A. All rights reserved. www.merckmillipore.com/techservice