University of Toronto Mississauga

Fall 2014 – BIO152H5F – Intro. Evolution & Genetics

Term Test I: Thursday, October 9th, 2014 (CC1080)
Duration: 40 minutes
Allowable Aids: NONE

Version A
INSTRUCTIONS: Please fill in your NAME, AND STUDENT NUMBER, below. On
your SCANTRON SHEET, please fill in your NAME, STUDENT NUMBER and
SIGNATURE. Also, please CIRCLE A in the FORM BOX on the Scantron sheet.
FAILURE to complete the FRONT COVER of this test OR SCANTRON FORM
correctly, will result in a DEDUCTION of your FINAL MARK!

BIO152H5F TERM TEST I has:

THIRTY Multiple Choice Questions (Each worth 1 mark = 30 marks)

– Multiple Choice Questions MUST be answered on the Scantron sheet provided!
– Remember to fill in your name, student number, and signature. Circle
FORM A on your Scantron sheet using an HB pencil!

ONE BONUS Mutliple Choice Question (Question 31) worth 1 mark.

– Please make sure to check that you have ALL 10 Pages!

*** At the END of this test, you must submit BOTH the Test Booklet & Scantron
Sheet!

– Term Test I has a total of 30 marks and is worth 10% of your final grade!
Good Luck!

Name:
ANSWERS KEY
Student Number:

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Multiple Choice Questions (1-31) MUST be answered on the Scantron sheet. Choose the single best
answer for each question. You will NOT be given additional time to transfer your answers to the
Scantron sheet at the end of the examination. Answers on this exam paper WILL NOT BE MARKED!
(30 marks +1 bonus mark)

1.) When applying the process of science, which of these is specifically tested?
A. a question
B. a result
C. an observation
D. a prediction
E. a hypothesis

2.) A controlled experiment is one in which:

A. The experiment is repeated many times to ensure that the results are accurate.
B. The experiment proceeds at a slow pace to guarantee that the scientist can carefully
observe all reactions and process all experimental data.
C. There are at least two groups, one of which does not receive the experimental
treatment.
D. There are at least two groups, one differing from the other by two or more variables.
E. There is one group for which the scientist controls all variables.

3.) Imagine your friend discovers a new unicellular organisms that has a DNA genome and ribosomes
but no other cytoplasmic organelles. Which Domain of life would this new organism belong to?
A. Archaea.
B. Bacteria.
C. Eukarya
D. A or B is possible.
E. A, B, or C is possible.

4.) Which of the following best summarizes the results seen on the graph below?
A. Predators always avoid snakes with brightly coloured rings.
B. Predators avoid snakes with brightly coloured rings when Coral snakes are absent.
C. The experiment proves that mimicry was occurring.
D. The experiment supports the mimicry hypothesis.
E. None of the above.

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 5.) Given the relative electronegativities of the elements, a molecule with the formula CH 4 would have
which type of bonds?
A. nonpolar covalent bonds
B. polar covalent bonds
C. ionic bonds
D. organic bonds
E. All of the above bonds in equal proportions.

6.) Which one of the following hypothetical changes in a water molecule would tend to make it more
polar?
A. It is a linear molecule, as in H-O-H.
B. Adjacent water molecules form covalent bonds with each other.
C. The electronegativity values for H is increased.
D. The electronegativity value for O is increased.
E. None of the above changes would make water more polar.

7.) After 10 years of research, a scientist from Canada’s Department of Fisheries and Oceans found
sea urchin populations had declined by 25%. Which of the following is the most likely
explanation?
A. The number of sea urchin predators had declined.
B. A decrease in pH caused an increase in calcium carbonate availability.
C. A decrease in pH caused a decrease in calcium carbonate availability.
D. An increase in pH caused a decrease in calcium carbonate availability.
E. None of the above.

8.) The average mass of a female Vancouver Island marmot is 5.0 kg. Where did the carbon found in
the marmot originally come from?
A. Nutrients in the soil
B. Water
C. Atmosphere
D. Minerals in the soil
E. None of the above

9.) Which type of biological polymer has the least diversity in physicochemical properties and
structure?
A. Polysaccharides
B. polypeptides
C. DNA
D. RNA

10.) How would you classify the molecule right?

A. deoxyribose sugar
B. pyrimidine
C. amino acid
D. nucleoside
E. None of the above

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 11.) Which of the following statements most accurately summarizes a relationship between genome
size and organismal complexity?
A. On average, humans have the largest genome size of all animals.
B. On average, animals have larger genome sizes than plants.
C. On average, multi-cellular eukaryotes have larger genome sizes than uni-cellular
eukaryotes.
D. On average, eukaryotic organisms have larger genome sizes than prokaryotic
organisms.

12.) Imagine that you isolate some cells in metaphase of meiosis I from a rat and prepare them on
slides for immunofluorescence light microscopy with staining for chromatin and the cytoskeleton.
Imagine that you do the same for cells in metaphase of mitosis from the same animal. You have
two sets of slides but you forgot to label them and they become mixed up. Which of the following
observations would allow you to distinguish the mitosis slides from the meiosis slides?
A. Only cells on the meiosis slides would have sex chromosomes.
B. Only cells on the meiosis slides would show homologues paired together.
C. Only cells on the mitosis slides would contain microtubules attached to the centromeres.
D. Cells on the meiosis slides would have half as many chromosomes as those on the mitosis
slides.
E. Cells on the mitosis slides would have replicated chromosomes (composed of two
chromatids each); cells on the meiosis slides would have unreplicated chromosomes.

13.) If a mitochondrion “died” inside a cell, it would be broken down by enzymes. Where would such
enzymes be located?
A. In the cytoplasm.
B. In a lysosome.
C. In a secretory vesicle.
D. In the smooth endoplasmic reticulum
E. None of the above.

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 14.) The four figures below each show the karyotype of a mosquito (2n=6 chromosomes) that is
heterozygous for two genes, T and B. Which of the figures correctly shows the relative location of
the various alleles on the chromosomes? (A)

15.) Consider a penguin gamete. The amount of DNA in this gamete is defined as “1C”. The number of
chromosomes in this gamete is defined as “1n”. That is, the value of C and the value of n are equal
in penguin gametes. During which stage of penguin cell division would be value of C and the value
of n be equal?
A. During G1 of a skin cell; both n and C equal 2
B. During G2 of a liver cell; both n and C equal 4
C. During metaphase of meiosis II; both n and C equal 1
D. During metaphase of mitosis; both n and C equal 2

16.) The cutting and pasting of DNA backbones giving rise to recombinant chromatids is a
fundamental aspect of meiosis and the sexual life cycles of eukaryotes. When does this process
occur?
A. During integration of transposons into chromosomes.
B. During S phase of the cell cycle.
C. During metaphase of meiosis II.
D. During prophase of meiosis I.

17.) The drug 5-bromouracil (5BU) is used to treat certain forms of cancer. This toxic compound
resembles thymine (T) and is incorporated into growing DNA chains across from adenine (A). If
5BU is provided to a cancer cell entering S phase, where will this drug be found in the
chromosomes of newly formed daughter cells following mitosis?
A. All of the chromosomes inherited by all daughter cells would contain 5BU.
B. Only half of the chromosomes inherited by any given daughter cell would contain 5BU.
C. Only half of the daughter cells would have 5BU in all of their chromosomes; the other half
of the daughter cells would have no 5BU in their chromosomes.
D. None of the above.

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 18.) Privet shrubs and humans each have a diploid number of 46 chromosomes per cell. Why are the
two species so dissimilar?
A. Privet chromosomes undergo only mitosis.
B. Privet chromosomes are shaped differently.
C. Human chromosomes have genes grouped together differently.
D. The two species have appreciably different genes.
E. None of the above.

19.) Tay-Sachs disease causes nerve cells to malfunction and is usually lethal by age 4. Two healthy
parents know from genetic testing that they are both carriers of the recessive allele responsible
for this disease on chromosome 15. If this couple conceives two children, what is the likelihood
that they will both be unaffected (healthy) and male?
A. (3/4 x 1/2)2
B. (3/4 x 1/2) + (3/4 x 1/2)
C. 1 - (3/4 x 1/2)2
D. 2 x (3/4)2
E. None of the above.

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Case Study – Use the following paragraph below to answer Questions 22 and 23:

Some people in Mexico are famous because they are very hairy. Victor and Gabrielle Ramos Gomez are
brothers who perform as trampoline acrobats. They also have thick dark hair growing over their faces
and most of their bodies. This human disorder, called Ambras Syndrome, shows sex-linked dominant
inheritance. The hairy Gomez brothers have a mother (Louisa) who, like them, is affected by Ambras
Syndrome. However, Louisa’s excessive hair growth occurs in variously scattered patches on her skin
rather than in a “full body beard” like her sons. Karyotype analysis shows that the mutation causing the
disorder in affected members of this family is a chromosomal inversion.

20.) If Victor has a family with a normal woman, what can you predict about the distribution of
hairiness among his children?
A. Sons will be affected; daughters will not.
B. Daughters will be affected; sons will not.
C. Half of the sons will be affected; none of daughters will be affected.
D. Half of daughters will be affected; all of sons will be affected.
E. You need more information to answer this question.

21.) What is the most likely explanation of the patchy expression of hairiness on Louisa’s skin??
A. During development, Louisa randomly inactivated one X chromosome in her cells.
Therefore, some patches of skin express the normal X; some patches express the
mutant X.
B. During development, Louisa formed by fusion of two different embryos. Therefore, some
patches of skin express the normal X; some patches express the mutant X.
C. Just after fertilization, the zygote that gave rise to Louisa underwent recombination
between her two X chromosomes. Therefore, some patches of skin express the normal X;
some patches express the mutant X.
D. Louisa is actually an XXY individual. Therefore, some patches of skin express the hairless
female (XX) chromosomes; some patches express the hairy male (XY) chromosomes.
E. You need more information to answer this question.

22.) In humans, colour blindness is a recessive trait carried on the X chromosome. Imagine that a
couple, Watson and Mary, have a colour-blind daughter with the unusual karyotype of 45, X. That
is, she has only one X chromosome instead of the usual two. Although Watson and Mary both have
normal colour vision and normal karyotypes, Mary’s father was colour-blind. Where could an
error in meiosis have occurred that would have given rise to this colour-blind daughter with only
one X chromosome?
1. Non-disjunction in Watson at Meiosis I.
2. Non-disjunction in Mary at Meiosis II I.
3. Non-disjunction in Watson at Meiosis II.
4. Non-disjunction in Mary at Meiosis II.
A. 1,2,3
B. 1,3
C. 2,4
D. 4
E. 1,2,3,4

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 23.) In humans, the normal CCR5 allele codes for a cell surface receptor that is used by HIV to infect
host cells. The mutant CCR5-Δ 32 allele codes for an alternative receptor that renders homozygous
people highly resistant to HIV infection. People with one mutant allele and one normal allele are
somewhat less resistant and homozygous “normal” people are sensitive to infection. What does
this tell us about the CCR5-Δ 32 allele?
A. The CCR5-Δ 32 allele is co-dominant.
B. The CCR5-Δ 32 allele is not very helpful.
C. The CCR5-Δ 32 allele is recessive.
D. The CCR5-Δ 32 allele is dominant.
E. None of the above.

24.) What is the probability that III-2 in the pedigree to the right is a carrier?
A. 0
B. 1/2
C. 1/4
D. 1/3
E. 1
F. None of the above.

25.) If II-1 from the pedigree to the right marries a normal

female (that doesn’t carry the mutation), what is the
probability that they would have a carrier daughter?
A. 0
B. 1/2
C. 1/4
D. 1/3
E. 1/6
F. 1
G. None of the above.

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 26.) Your paternal great-grandma had a sister that died from cystic fibrosis. What are the chances
that you are a carrier?
A. 1/2
B. 1/6
C. 1/8
D. 1/12
E. 1/16
F. 0

27.) Your maternal grandfather had a brother that died from Huntington’s disease. What are the
chances that you are a carrier?
A. 1/2
B. 1/3
C. 1/4
D. 1/6
E. 1/8
F. 0

28.) For the organism of genpytpe AABbCcDDEe, (homozygous for 2 genes, heterozygous for 3
genes), how many different types of gametes will be made if the 5 genes are all on different
chromosomes?
A. 2
B. 3
C. 4
D. 8
E. 9
F. None of the above

29.) For the organism of genotype AABbCcDDEe, (homozygous for 2 genes, heterozygous for 3
genes), how many different types of gametes will be made if the C gene and the E gene are linked
on the same chromosome?
A. 2
B. 3
C. 4
D. 8
E. 9
F. None of the above

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 30.) Which of the following do mitochondria and chloroplasts have in common?
1. prokaryotic origin
2. contain ribosomes
3. contain DNA
4. present in plant cells

A. 1,2,3
B. 1 and 3
C. 2 and 4
D. 4 only
E. 1,2,3,4

31.) BONUS QUESTION: Imagine that you run a fertility clinic and see a couple, Bart and Angelina,
who have a young daughter Georgie. The sad news is that Georgie has leukemia and needs a tissue
transplant from a compatible donor – neither of her parents is a match. Therefore, Bart and
Angelina want you to use their gametes to create several embryos. Then the couple wants to
become pregnant only with an embryo that is both female and a tissue match for Georgie.
Assuming that Bart has HLA haplotypes 3 and 17; and Angelina has HLA haplotypes 3 and 29;
what fraction of their total embryos would likely be female and a tissue match for Georgie? (You
don’t need to know Georgie’s genotype to answer this question)
A. 1/8
B. ¼
C. ½
D. 2/3
E. None of the above.

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