Scheme

Course Title Fundamentals of Cell Course Integrated

Biology Type

Course Code P1UC101B Class- UG First

Programs

Instruction Activity Credi Credit Total Number of Assessment

delivery ts Hours Classes per Semester in Weightage

Lecture 3 3 T Tu P Se CIE SE
h tor r lf- E
Tutorial 0 0 e ial a st
o c ud
Practical 1 2 ry t y
i
Self- 0 0 c
study a
l

Total 4 5 45 0 30 0 50% 50%

Names Course Course

Instructors Lead

Theory Practical

Dr. Renu Bhardwaj Dr. Pragati Singh

COURSE OVERVIEW
This course aims to introduce students to biomolecules and important fundamental
concepts in cellular biochemistry, genetics and cellular organisation. It is aimed to give
you an insight into how biomolecules work and help drive cellular architecture and
function in a eukaryotic cell. In the first part, we focus on the information that makes the
cell tick; from its storage in DNA to its conversion to executive molecules such as RNA
and protein that perform essential routine processes in the cell. The central dogma is
used as a guide to explore the structure of DNA, RNA and Protein and also explore the
mechanisms of DNA replication, transcription and translation. Also touched upon are
other important molecules such as water, carbohydrates and lipids. In the second part,
we introduce basic mechanisms of heredity, as discovered by Gregor Mendel, in a
modern context. In the third part, we will be discussing cell theory and the evolution of
complexity in cells and the role compartmentalisation plays in mediating the same. The
organisation of cells starting from the cell membrane as we move into the cell will be
discussed. We will be looking at the role cytoskeleton have in cellular organisation and
function. We will also be discussing organisation, role and regulation of cell organelles,
everything from the endomembrane system to lysosomes to the nucleus. Eventually, we
will be briefly discussing how all these cellular components come together to drive the
process of cell division.

PREREQUISITE COURSE

PREREQUISITE COURSE REQUIRED Students should qualify 10+2 or

equivalent examination in Science
stream with Biology subject
If, yes please fill in the Details Prerequisite Prerequisite
course code course name

COURSE OBJECTIVES
Students are able to understand the basic concept of land plant kingdom classification,
anatomy, reproduction and developmental changes.

COURSE OUTCOMES (COs)-

The student at the completion of the course will learn:
● To understand the structures and purposes of basic components of prokaryotic
and eukaryotic cells, especially macromolecules, membranes, and organelles.
● To understand how these cellular components are used to generate and utilize
energy in cells.
● To understand the cellular components underlying mitotic cell division.
● To understand responses to environmental or physiological changes, or
alterations of cell function brought about by mutation.
● To understand the process of cell division in both somatic and germ cell.
●

Course Outcomes (COs)- After the completion of the course, the student will be able to:
CO1 Identify cell types, structure, functions and differentiate between
various cell organelles.
CO2 Interpret the membrane biochemistry and transport of ions
across the membrane.
CO3 Summarize the different types Cell-Cell Interaction and cellular
communication.
CO4 Demonstrate protein sorting and transport.
CO5 Express the knowledge cell aging and death.
BLOOMS’S LEVEL OF THECOURSE OUTCOMES: Bloom’s taxonomy is a set of
hierarchical models used for the classification of educational learning objectives into
levels of complexity and specificity. The learning domains are cognitive, affective, and
psychomotor.
CO No.-CO

CO No. Bloom’s Taxonomy Level (BTL)

Remembe Understan Apply Analyze Evaluate

r (L1) d (L2) (L4) (L5)
(L3)

CO1 √

CO2 √

CO3 √

CO4 √

CO5 √ √

PROGRAM OUTCOMES
Program Outcomes (POs):
PO-1: Apply the principles and conceptual knowledge of basic and applied science to
understand and solve the complex biological problems.

PO-2: Employ critical thinking and the scientific knowledge to design, carry out,
record and analyze the results of biological reactions.

PO-3: Create, select and apply appropriate techniques, resources and modern science
appropriate consideration for public health and safety.

PO-4: Apply reasoning informed by the contextual knowledge to assess societal,

health, safety, legal issues and the consequent responsibilities relevant to the
professional biologist.

PO-5: Understand the impact of professional life sciences solutions in communal

and environmental contexts and demonstrate knowledge and need for sustainable
 development.
PO-6: Articulate ideas, comprehend and write effective reports, documentation and
to communicate effectively with the basic and applied sciences community and with
society at large, professionally and ethically.

PO-7: Demonstrate knowledge and understanding of science and technical

principles to manage projects in multidisciplinary research areas and function
effectively as an individual, and as a member or leader in diverse resource teams.

PO-8: Seeking stimulation and to exploring numerous opportunities to engage in

independent and life-long learning in the broadest context of technological change.

Program Specific Outcomes (PSOs):

PSO 1: Igniting young minds, from different backgrounds to understand the world of
biological Science processes through application-based learning.

PSO2: Equip students with analytical and technical skills to practice evidence based
biological Science for industrial applications.

As defined by the concerned Apex bodies

COURSE ARTICULATION MATRIX: The Course articulation matrix indicates the
correlation between Course Outcomes and Program Outcomes and their expected
strength of theree levels (low, medium, and high).
COs#/ PO PO PO PO PO PO PO PO PS P
1 2 3 4 5 6 7 8 O1 S
POs
O
2
CO1 2 2 3 2 3
CO2 2 3 3 3 3
CO3 2 2 3 3 2 3
CO4 3
CO5 3 2 3 3
Note: 1-Low, 2-Medium, 3-High

COURSE ASSESSMENT: The course assessment patterns are the assessment tools
used both in formative and smmative examinations.
 S. Assessme CIE Total SEE
No. nt Tools CIE
CAT CAT QUIZ2 QUIZ1 LAB LAB Cou
mark
1 2 EXAM rse-
s
bas
ed
Proj
ect
1 Integrated X X X X
30 30 0 0 20 20 100 100
CAT: Continuous Assessment Test; SEE: Semester End Examination;

COURSE CONTENT

CONTENT

Theory

Introduction to the cell, its chemical composition, Cell types - organization of

prokaryotic and eukaryotic cells, Plant and animal cells: variation in structure and
function, cell theory. Structure and functions of cell organelles – Nucleus,
mitochondria, chloroplast, ribosome, lysosomes.

Membrane: chemical composition and its structural plan; molecular model of cell
membrane - fluid mosaic model and membrane fluidity; Overview of types of
transport systems and macromolecule transport: Exocytosis; Endocytosis;
Pinocytosis and phagocytosis.

Cell Wall: Eukaryotic cell wall, Extracellular matrix and cell matrix interactions, Cell-
Cell Interactions - adhesion junctions, tight junctions, gap junctions, and
plasmodesmata. Cytoskeleton: Structure and organization of actin filaments,
association of actin filaments with plasma membrane, cell surface protrusions,
intermediate filaments, microtubules.
Endoplasmic Reticulum – Structure, targeting and insertion of proteins in the ER,
protein folding, processing and quality control in ER, smooth ER and lipid synthesis,
export of proteins and lipids Golgi Apparatus – Organization, protein glycosylation,
protein sorting and export from Golgi Apparatus.

Cell cycle - phases of cell cycle; cell division - mitosis and meiosis; Cell cycle
regulation; Cell aging and death - necrosis and apoptosis; Stem cells. Types:
Embryonic stem cell, induced pluripotent stem cells.

Practical

1. Preparation of permanent slide/video to demonstrate:

i DNA by Feulgen reaction

ii DNA and RNA by MGP

iii Mucopolysaccharides by PAS reaction

iv Proteins by Mercurobromophenol blue/Fast Green

2. To study the principle and applications of important instruments

(Microscope, Spectrophotometer, autoclave, Centrifuge) used in the laboratory.

3. Qualitative analysis of carbohydrates presents in the given solution.

4. Qualitative analysis of amino acid and protein present in the given solution.

5. Qualitative analysis of lipid present in the given solution.

6. To understand the principle of Osmosis and Diffusion.

7. Demonstration of different stages of mitosis.

8. Demonstration the different stages of meiosis.

 9. Preparation of permanent slide/photo to show the presence of Barr body in
human female blood cells/cheek cells.

BIBLIOGRAPHY

TextBook

1. Molecular Biology of the Cell (2008) 5th ed., Alberts, B., Johnson,A., Lewis, J.,
and Enlarge, M., Garland Science (Princeton), ISBN:0-8153-1619-4 /
ISBN:0-8153-1620-8.
2. The Cell: A Molecular Approach (2009) 5th ed., Cooper, G.M. and Hausman, R.E.,
ASM Press & Sunderland (Washington DC), Sinauer Associates, MA,
ISBN:978-0-87893-300-6.
3. Molecular Cell Biology (2012) 7th ed., Lodish, H., Berk, A., Zipursky, S.L.,
Matsudaira, P., Baltimore, D. and Darnell. J., W.H. Freeman & Company (New
York), ISBN:13:978-1- 4641-0981-2 / ISBN:10: 1-4641-0981-8.

ReferenceBooks

1. Molecular Cell Biology (2012) 7th ed., Lodish, H., Berk, A., Zipursky, S.L.,
Matsudaira, P., Baltimore, D. and Darnell. J., W.H. Freeman & Company (New
York), ISBN:13:978-1- 4641-0981-2 / ISBN:10: 1-4641-0981-8.

2. Molecular Biology of the Cell (2008) 5th ed., Alberts, B., Johnson,A., Lewis, J.,
and Enlarge, M., Garland Science (Princeton), ISBN:0-8153-1619-4 /
ISBN:0-8153-1620-8.
Journals/Magazines/Govt. Reports/Gazatte/Industry Trends
1. https://www.cell.com/cell-reports/home
2. https://www.cell.com
3. Journal of Cell Biology (JCB) | Rockefeller University Press (rupress.org)

SWAYAM/NPTEL/MOOCs
1. Introduction to Cell Biology - Course (nptel.ac.in)
 2. https://nptel.ac.in/courses/102103012
3. https://nptel.ac.in/courses/102103012

Webliography
1. https://sist.sathyabama.ac.in/sist_coursematerial/uploads/SBMA1101.pdf