Detailed Lesson Plan

Detailed Lesson Plan
Specializati EARTH & LIFE SCIENCES Grade 11

on: Level:
Date: January 15, 2024 Section: ESCOLAR FISH
DLP No.: Quarte 2nd Quarter Duration 1 hour
r: :
Content Standard 1. plant and animal reproduction Code: S11/12LT-IIej- 17
2. how genes work
3. how genetic engineering is used to produce novel products
Performance conduct a survey of products containing substances that can trigger genetic disorders such as
Standard phenylketonuria
Learning Describe the process of genetic engineering
Competencies:
Resources: CG,
https://shorturl.at/douHM
LEARNING OBJECTIVES
Describe and
Knowledge:
explain the hazards

associated with
earthquakes;
Describe and
explain the hazards
associated with
earthquakes;
Define genetic engineering
Skills: Describe Recombinant DNA technology and gene splicing as techniques in genetic engineering
Attitude: Instill a strong desire to know or learn something or the value of curiosity
PROCEDURES
Preparatory 1. Prayer
Activities 2. Greetings
5 minutes 3. Checking of Attendance
4. Review the past lesson
5. State the objectives of the lesson to the class.
ELICIT Activity 1- 4 Pics 1 Word Challenge!
Direction: Guess the word that connects the four given pictures correctly. Write your answer on the
answer sheet provided (per group).
1. PROTEIN
2. STRAND
3. GENETICS
4. ENGINEER
5. CHANGE
ENGAGE Activity 2- Question & Answer Challenge!
Let the student respond to the query,
If given a chance, which physical feature, aspect of who you are, or aspect of your personality would
you alter or change, and why?
EXPLORE Activity 3- Gene Splicing Activity!
OBJECTIVES: Illustrate how the production of Human Growth Hormone is done using Recombinant
DNA Technology.
Materials: long bond paper, scissors, clear tape and colored paper
1. Prepare the materials

2.Cut a one-inch-wide strip of the bond paper vertically (longer side). Shape it a
circular loop and secure it with tape. This represents a bacterial plasmid.
3. Cut a one-inch-wide strip of the colored paper horizontally. This represents
the gene coding for human growth hormone.
4. To do “gene-splicing”, use the scissors to cut open the plasmid. The scissors
represent the restriction enzymes opening the plasmid.
5. Tape the colored paper into the place where the plasmid was open, reforming
the loop. The tape represents the enzyme ligase that affixes the new gene into
the plasmid. This new plasmid with recombinant DNA is ready to be inserted
into a bacterium so it can make growth hormone.
A. Guide Question:
1. What is gene splicing?

2.What does the bond paper represents? What about the colored paper? Scissors? Clear tape?
Activity 4- Lecture on Recombinant DNA Technology!
B. Guide Question:
1. What is a plasmid? What is the function of plasmid in recombinant DNA?
2.What are the functions of restriction enzyme and the enzyme ligase?
3. How is the Human Growth Hormone produced? (refer to the illustration)
4.What is recombinant DNA? Describe the process of recombinant DNA technique.
EXPLAIN GENETIC ENGINEERING

- is the processes of changing the DNA in living organisms to create something new.
The target of adding on one or more DNA is to have one or more traits that are not found in a certain
organism.
It can also be a process of inserting or transferring a gene of a specific trait into another organism.
(Recombinant DNA Technology)
RECOMBINANT DNA TECHNOLOGY

-
Is the technique of combining two DNA sequences from different sources.
One goal of this technique is producing a particularly useful protein product.
The tools used in Recombinant DNA technology are restriction enzymes,enzyme ligase, vectors and
host organisms.
Plasmid is a small , circular,double-stranded DNA molecule used as vector in recombinant DNA
technology.
Restriction enzymes- DNA cutting enzymes, is a protein that recognizes a specific short nucleotide
sequence and cuts the DNA only at the specific site.
Enzyme Ligase- DNA joining enzyme, they are capable of catalyzing the reaction of joining two large
molecules by establishing a new chemical bond.
Earth is mainly
ELABORATE
composed of rocks
that differ in
terms of sizes,
shapes and colors.
Though rocks
seemed to be very
hard, dense and
indestructible,
they still break.
The breaking of
rocks is called
weathering.
From our activity, the
chalk represented the
rocks
and through the
agents of weathering,
which in our
activity is the
hammer, rocks break
gradually and
eventually turn to soil.
Earth is mainly
composed of rocks
that differ in
terms of sizes,
shapes and colors.
Though rocks
seemed to be very
hard, dense and
indestructible,
they still break.
The breaking of
rocks is called
weathering.
From our activity, the
chalk represented the
rocks
and through the
agents of weathering,
which in our
activity is the
hammer, rocks break
gradually and
eventually turn to soil.
WHAT DO YOU THINK ARE THE OBJECTIVES OF SCIENTIST IN GENETIC ENGINEERING?
Activity 5: From Genes to Glucose!
EVALUATE Direction: Arrange the steps in Insulin Production chronologically. Answers should be posted on the
board.
STEP BY STEP PROCESS OF INSULIN PRODUCTION

1. Scientists identify the segments in the DNA where synthesis of insulin is encoded called the insulin
gene.
2. They use an enzyme to cut the insulin gene out of the DNA strand.
3. Plasmid as container of the gene is removed from a bacterium.
4. Plasmid is cut open.
5. Insulin gene is inserted into the plasmid.
6. Enzyme ligase affixes the insulin gene in the plasmid.
7. Plasmid is inserted back to the bacterium and the bacterium will multiply and the insulin
production happens.
Choose the letter of the best answer. ¼ Sheet
EXTEND 1. What biotechnological process is described as the adding a DNA segment containing a trait to the
genome of another organism?
a. Recombinant DNA c. In Vitro Fertilization (IVF)
b. Genetic engineering d. Production of GMO’s
2. What technique in genetic engineering combines two DNA sequences from different sources?
a. GMO’s b. Recombinant DNA c. Cloning d. IVF
3. These are organisms or microorganisms whose genetic material have been altered to contain a
segment of DNA from another organism.
a. plasmid b. Enzyme c. GMOs d. Bacteria
4. It is a small, circular, double stranded DNA molecule used as vector in recombinant DNA
technology.
a. Plasmid b. Restriction enzyme c. Ligase d. Bacteria
5. Which is NOT an application of genetic engineering?
a. Production of medically useful enzymes or proteins?
b. Raising of crops and plants that are pest resistant
c. Cloning of animals
d. None of the above
Remarks:
Reflection:
Prepared by: Process Observer:
GLADYS S. PURACAN AIRA L. TUBIANO

Teacher II Master Teacher II

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Specializati EARTH & LIFE SCIENCES Grade 11

explain the hazards

ENGAGE Activity 2- Question & Answer Challenge!

Let the student respond to the query,

EXPLORE Activity 3- Gene Splicing Activity!

1. Prepare the materials

1. What is gene splicing?

Activity 4- Lecture on Recombinant DNA Technology!

EXPLAIN GENETIC ENGINEERING

RECOMBINANT DNA TECHNOLOGY

STEP BY STEP PROCESS OF INSULIN PRODUCTION

Prepared by: Process Observer:

GLADYS S. PURACAN AIRA L. TUBIANO

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