Base

Char
SNu
OMCReacrfty
’ ho
take acddlc HD eSt Acd DeriV. SNTh alky| metal.
onen r Szet
Carbony. NPaddition Reacivity ‘ RK>Na> PL
VøAra JAhakdecX me CHz

yEther Reacbivity cH
PrecatSow3 i h a sXorA6r
Solvtion no acde noTnally stable
energy Prep H Adà De heatng stable
3000 pola caroony|
Solents Allyl hcrd et Excesc mg) Ether
Stab \Rsec uR. Extended SN2.
Allene
2erewitinefe SN2

CHsmgI +
HZcHuf+g(zL
no ofmoles of
this no-of mdes o HxyH,NH
acldic H/molee of as base SH
Z

Fotgetble
 N

Alkyl Hafde tSterc then 4t Amid 2° Jsone, jost

Rntenl
e so L
2 degree Aaide. nofovtheE
(strorg
arfonfcN )
Retone.
Epotde Base Cotalysed
Rng openg
(0CAOTCgarfide

oimilar mech
S) Halogentmgr Oyorogen
A)denydS, Vetones
H30

Rternal yeso.
no Borther Formaldeydefadcs
Aldehydes-2° ale
(etone3° alc.
Alcohdl OA)kyl yanide CRatta)
R-c=

no forther

oH Go l.
(H C-0EE
A
CTo base
Ralky carbonate
5e-c-0 c-e Et-o--0-Et

R- c -Et
refes Phenyl isocyonate
Ph- N =c
Ph-N= c-ot
refer
acilhalidel4
ketone

Esters RSH

R-cOR ((9) Holoe ther R-o-CH-x

etoreR (9) othoca borglake

--ok Ho R
ChlÛsomfne (Rott X

Denyortton
 betterthan G +1t
RC-NRcoOH
strong af base
CH3),CH
AlkgLiom) Bypases cO, wada
"Rnternal reso (cHa), CH CHs)CHt

coy Cct)tH

Pke At donor 1n
aR a Cs
e-e-oL
eco P-cOH
H -CHa

Carbonyl& 2x
Actyl Acetone thìs H
is acid
aswel
l e e Le 22 RLf

acid base R-c

e-6-cH-R bettey
r Nsite
happen
R-G-cH-C-RgEt +EtD[SNv\awllthis cavoon

RgCd preparati on of ketone (same GR mechan'sn)

lFancand Smonsymalkqne
Adenyde lcetone ) Hao
Rekonatsky d halo esterehydroy ester

Sfm monSmfth
R

CH2 Corey

elem.
wl3 helidec
 1) 2 add aster than lb add Direct add
S+ on carbon

a add more stable than 12 odd,

Conj ad d

Hgher bond eneg9

Nu
Kinetic Contxol coditions such that oy Toto.
KinetlcQYoduct eomed
JowT (Paster 2o2)
N
Thero control
ony themodyna i(
product fomes (mone
HrgkT stable)
Harà boTderIPne s oftOTgarocopper
(

RLL
. hard N u ) 2 add
F,oH,o,
Lene
NH aromatic rig

memg Br tCucemeC+glbid
oPll show l, add .