Shaping new dimensions

for HEMATOLOGY

Authorized Distributor in Bangladesh: Healthcare Diagnostic Solutions Ltd.

Expert blood cell counter, Yumizen H2500 and Yumizen H1500 Automated
Hematology Analyzer to answer the expectations of a solid diagnostic platform
with rapid and consistent result delivery

Tracking System

Analytical Unit

• Improved TAT (Turn Around Time): throughput - 120 samples/hour

• 360º homogenous mixing

H2500
• 9-part hematology analyzer with extended differentials

• Optical PLT 57 parameters

• Complete Reticulocyte Profile using Gold standard dye "Thiazole Orange"

• LPF (Large Platelet Fraction)

• Different analysis modes

• Body fluids
H1500
• NRBC by default in CBC, CBC + DIFF, DIR, CBC + Ret modes

• CVD Curves (Complexity, Volume & Distribution) for WBC differentials 46 parameters

• DIF_LV Mode - for Pancytopenia samples

Better inventory management with less reagents

• Only 6 in Yumizen H2500

• Only 5 in Yumizen H1500
• Reagents loaded in inverted position ensures minimal dead volume
• Ready to use reagents H2500
 Unique CVD curves for WBC differentials
Expert menus for 3-Dimensional analysis
(CVD: Complexity, Volume & Distribution)

Middle Ware
Slide Making
System
& Staining System

Digital Cell Morphology

In Blood Mode
• LMNE Vol.: LMNE impedance multi-histogram
• LMNE Abs.: LMNE absorbency multi-histogram
• LYM Vol.: Lymphocytes impedance histogram
• NEU Vol.: Neutrophils impedance histogram
• NEU Abs.: Neutrophils absorbency histogram

In Body Fluid Mode

MP Vol.: Mononuclear cells/Polymorphonuclear cells impedance histogram
MP Abs.: Mononuclear cells/Polymorphonuclear cells absorbency histogram

Histograms for WBC, RBC, PLT, RBC/PLT & Baso

RBC/PLT RBC BASO PLT WBC

Histograms clearly demarcating

different type of cell populations
based on morphology & quantification
 Extended diff matrix & measurement of WBC in Near Native State
for better screening of morphological changes in abnormal cases

Counting WBC from three different chambers and three different lyse for accurate WBC Counting &
to enumerate Immature cell lines.

22 parameters for WBC differential

EOS IMG
• WBC NEU

• Total nucleated count

• Neutrophil % & # count
• Eosinophil % & # count
• Basophil % & # count
• Monocyte % & # count
• Lymphocyte % & # count
• Immature granulocyte % and #
• Immature lymphocytes % and #
• Immature monocytes % and #
ALY
MON IMM
• Large immature cells % and #
LYM IML
• Atypical lymphocytes % and #
• Count with direct measurement of each Leukocyte population
• LMNEB & IMG % & # Reportable

Proper segregation of NRBC & Platelet aggregates

• NRBC % & # values by default in CBC, CBC + DIFF,

DIR, CBC + Ret modes

• Separate NRBC & PLT aggregate indication on Scatterplot

• No extra reagent required

• Corrected WBC Count

NRBC

PLT aggregates
 NLR (Neutrophil to Lymphocyte Ratio)
Prognostic value in cardiovascular diseases, infections, inflammatory conditions

SEPSIS MONITOR SEPSIS MONITOR

Reletionship between NLR and bacteremia in a heterogeneous patient population
(Low NLR & bacteremia) (High NLR & bacteremia)
- Patients with bacteremia who are - Patients with septic shock MR A new prognosis indicator_NLR
tolerating this well (not shocked or and becteremia • NLR is Neutrophil to Lymphocyte count Ratio, it’s calculated from CBC result,
severely ill). easy-to-use parameter.
Bacteremia

(Low NLR, no bacteremia) (High NLR, no bacteremia)

• Study6 in beijing showed that cut-off value of NLR is 3.13, sensitivity is 0.875 and
- Most patients presenting - Septic shock patients with negative blood cultures specificity is 0.717.
to emergency department - Cardiogenic shock
- Massive pulmonary embolism
- Severe pancretitis • Patients should be transferred to ICU with age >50 and NLR>3.13. if NLR<3.13 and
- Lot’s of other patients with severe illness age<50, the patients could isolate at home or community hospital.
Neutrophil / Lymphocyte Ratio

Takayuki Honda – International journal of clinical chemistry Jingyuan et al - Journal of translational medicine
Reference Jiawei Jang – The American Journal of emergency medicine Reference Kuiken T et al – The Lancet
Cornelis PC de Jager et al – Journal of Critical care Drosten C et al – The new England Journal of Medicine

MIC & MAC for Anemia Classification

• Percentage value of Microcytic (MIC) & Macrocytic (MAC)

population of RBC

• Gives additional insight about RBC morphology

• Helpful in segregation of iron deficiency anemia and Vitamin

B12 deficiency anemia

DIF_LV mode

• Dedicated mode exclusively designed for Low value of WBC, RBC & PLT (pancytopenia samples)
• Gives CBC + WBC Differential for low values

Body fluid application

Polynucleated cells
Mononucleated cells Immature cells
• 6 reportable body fluid parameters – BFWBC, BFRBC, BFPN#,
BFPN%, BFMN#, BFMN%
BF
• Applicable for: CSF, Pleural, Peritoneal fluid & Synovial fluid Background
Noise High
• 2 Histograms –
• MP Vol.: Mononuclear cells/Polymorphonuclear
cells impedance histogram
• MP Abs.: Mononuclear cells/Polymorphonuclear
Background
cells absorbency histogram Noise Low
 Reticulocyte count
(only available in Yumizen H2500)

• Dedicated Retic mode based on Fluorescent flowcytometry

• Staining Dye - Gold standard : Thiazole orange
• Reticulocyte immaturity gradient (High, Medium, Low)

RET Parameters Definition

RET% Reticulocytes percentage
RET# Reticulocytes absolute value
RETL% Reticulocytes with a low RNA content
RETM% Reticulocytes with a medium RNA content
RETH% Reticulocytes with a high RNA content
CRC Corrected Reticulocyte Count
MRV Mean Reticulocyte Volume
IRF Immature Reticulocyte Fraction
RHCC Reticulocyte Hemoglobin Cellular content

Optical Platelet mode for better clarity between Microcytic RBC & Macro Platelet
(only Yumizen H2500)

Based on Optical extinction and Refractive Index 18 parameters

• RBC • MIC%, MAC%

• Hemoglobin • PLT
RBC-O
• Hematocrit • MPV
• MCV • PDW
• MCH • P-LCC
• MCHC • P-LCR
• RDW-CV • PLT-O
• RDW-SD • LPF PLT-O

RBCo/ PLTo Matrix

LPF (available only in Yumizen H2500)

• The LPF (Large Platelet Fraction) parameter represents young

platelets and is based on Optical extinction and refractive Index.
• Rise of LPF is an indicator of early BM activity, this information can RBC-O
be helpful in avoiding unnecessary PLT transfusion
• LPF counts all young PLT including PLT with low RNA content
which are generally missed in laser based technology.

LPF

LPF in PLT-O Scatter

 Improve your laboratory workflow with
Yumizen P8000 : AI based Middleware

• Middleware and expert validation station with Multi site management capacities

• Centralized patient’s results validation and Quality Controls management

• Supervision (Real time alerts): TAT monitoring, Multi instruments connectivity, global worklists

• Facilitated technical & application support : remote access

• Standardized rules package: ISLH

• Integrated more than 190 rules

• Offering flexibility to customize rules for rerun, reflex tests, comments and the automatic validation process

• Complete traceability for accreditation

• Storage: up to ~ 20,00,000 results

• Delta check, Patient moving average feature

P8000

Yumizen SPS

• Automatic mode with dedicated needle: Programming reflex tests (Yumizen P8000): Results
(parameters, alarms, delta check, etc.) Demographics (service, prescriber, age, etc.)
bi-directional/query, reflex testing
• Manual stain mode (body fluids, bone marrow, leuko-concentrations…)
• Compatible with both Yumizen H1500 & Yumizen H2500
• Turn around time – 120 slides/hour
• Adaptable smearing process
• Availability of different staining protocols (May-Grunwald Giemsa, Wright, Wright Giemsa, etc.)
• 160 slide loaders (continuous loading)
• Loader for 8 slide-holding racks (continuous loading), 20 slides per rack

IEC61010-1: 2010

IEC61010-2-81: 2015

IEC6101-2-101: 2015

IEC61326-1: 2013

IEC61326-2-6: 2013


SPS
HORIBA Evolutive Laboratory Organisation

HELO* solution compatible

PHYSICAL SPECIFICATIONS PARAMETERS & PERFORMANCE DATA

Yumizen H2500 & H1500: Analytical Measurements Range:
Dimensions (HWD; cm/in) & Weight (kg/lbs): 73 x 87 x 67 & 99 kg
28,7 x 34,3 x 26,4 & 218 lbs
Yumizen SPS:
Dimensions (HWD; cm): 44 x 91 x 72 & 60 kg (132 lbs)
Yumizen H2500 & H1500 with CIM:
Dimensions CIM (HWD; cm): 42 x 36 x 33 & 8 kg (18 lbs)

OPERATIONAL CONDITIONS
Altitude: until 2000m (6562 ft)
Sounds level: 57 dB
Operating Temperatu re : +15°C (+59°F) to +30°C (+86°F).
Parameters: Yumizen H1500 (46) / Yumizen H2500 (57)
Operating Temperatu re (with SPS) : +19°C (+66.2°F) to +26°C
(+78.8°F) CBC (20): WBC, RBC, HGB, HC T, MCV, MCH, MCHC, RDW-C V, RDW-SD, P LT,
P-LCC, P-LCR, MP V, PCT, PDW, MIC, MAC, NRBC# , NRBC%, TNC
Humidity: Relative humidity of 85% maximum, without condensation.
Humidit y (with SPS ) : Rela tive hu midity of 50% maximum for DIFF (20): LYM#, LYM%, MON#, MON%, NEU#, NEU%, EOS#, EOS%, BAS#,
temperatu res up to +26°C (+78.8°F). BAS%, A LY#, ALY%, IMG#, IMG%, IML#, IML%, IMM#, IMM%, LIC#, LIC%
Storage and Transport conditions: from -20°C (-4°F) to +60°C
(+140°F). RETICULOCYTES (9): RET#, RET%, CRC, IR F, RHCC, M RV, RETH, RETM,
RETL (available only on Yumizen H2500 model)
CONFIGURATIONS
BODY FLUIDS (6): BFWBC, BFRBC, BFPN#, BFPN%, BFMN#, BFMN%
Yumizen P8000: Expert validation station associated with Yumizen
H1500 & H2500, Yumizen H500 & H550 OPTICAL PL ATELET (2) : P LT-Ox, LPF (available only on Yumizen H2500 model)
Yumizen SPS : Slide maker stainer available on both models
Yumizen T6000: Track configuration available for Yumizen H1500, Throughput (automatic mode):
H2500, SPS.
CBC or DIFF : 120 samples / hour
Printer: Optional on Yumizen P8000
Reticulocyte or P LT-Ox or Low Value Cycle : 60 samples / hour
Protocols: Yumizen H1500 & H2500 with host: ASTM
SPS: 120 blood smears / hour
Yumizen P8000 with host: HL7
Sample volume:
SOFTWARE SPECIFICATIONS Automatic cycle 75 μL
Color LCD touch sc reen: 12.1 in.
Operating System: Windows® 10 IoT Enterprise 2016 LTBS Power supply and electrical consumption:
Processor: Intel® Celeron® J3455 2.3 GHz Power supply 100 V to 240 V (± 10%)
RAM (Random Access Memory): 4 GB 50 Hz to 60 Hz
Hard drive: SSD 256 GB disk, 2.5 S ATA3 Maximum consumption 200 VA
Ethernet, USB connections
Capacity: 100 000 results Reagents:
Reagents: May Grünwald
Giemsa
• ABX DILUENT
• ABX BASOLYSE
Buffer (pH 6.8 or pH 7.2)
• Yumizen NUCEDIFF Ethanol
• ABX LYSEBIO
• ABX FLUOCYTE (Only on H2500) Consumables:
• ABX CLEANER Slides frosted rounded corner, beveled edges.
Dimensions : 75 mm (+ 0/-1mm)
Graphic results: x 26 mm (+ 0/-1mm) x 1 mm (± 0.05mm)
10 histograms + 4 matrix
Smearing tape :
1 Strip for 6000 smears
CARRY OVER
WBC: < 0.5
Spreading profiles:
RBC: < 1
Defined and adjustable by
HGB: < 1
• Volume of drop deposited
PLT: < 0.5
• Degree of tilt
NRBC#: < 5
• Spreading speed
NRBC%: < 5
RET#: < 1
Standard slide-staining protocol:
RET%: < 1
May Grünwald Giemsa, Wright
BFWBC: < 0.5
BFWBC: < 1
Open slide-staining protocol:
Wright Giemsa
MADE IN
FRANCE

Hotline: 01313 44 88 33
HORIBA ABX SAS
Parc Euromédecine Rue du Caducée - BP 7290 34184 Montpellier cedex 4 - France Tel. : +33 (0)4 67 14 15 16 Fax : +33 (O)4 67 14 15 17
HORIBA Medical online: http://www.horiba.com/medical

Marketed and Distributed By: Healthcare Diagnostic Solutions Ltd. (A concern of Healthcare Pharmaceuticals Ltd.)
SEL HUQ Skypark (Level-08), 23/2, Khilji Road, Block-B, Shyamoli, Mohammadpur, Dhaka-1207, Bangladesh, Tel: +880-29632175, 9632176, www.hdsl.com.bd