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    Krebs Cycle

    Uploaded by

    Nora Meckiana Bahali
    General Biology 1

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Krebs Cycle

    Uploaded by

    Nora Meckiana Bahali
    1 views29 pages
    General Biology 1

    Copyright

    © © All Rights Reserved

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    PDF, TXT or read online from Scribd

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    General Biology 1

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    1 views29 pages

    Krebs Cycle

    Uploaded by

    Nora Meckiana Bahali
    General Biology 1

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    You are on page 1of 29

    Krebs Cycle

    Lesson Objectives
    At the end of the lesson, students are be able to:

    01 02 03

    Understand Know the steps in Know the Role


    the Krebs Cycle of Oxygen in
    the Krebs and the products Cellular
    Cycle formed Respiration
    What is Krebs Cycle?

    The Krebs cycle, also called the citric


    acid cycle, is a series of reactions in
    the mitochondria that helps convert
    food into energy.
    Krebs cycle takes place in the Matrix of the
    mitochondria
    Preparatory
    Stage

    Before the cycle starts, pyruvate from


    glycolysis is oxidized to form Acetyl-CoA(2c)
    Step 1
    •A two carbon molecule Acetyl CoA
    combines with a four carbon molecule
    Oxaloacetate to create six carbon
    molecule Citrate
    • This reaction is catalyzed by the enzyme
    Citrate Synthase
    Acetyl CoA (2c) Oxaloacetate (4c)
    🔴🔴 🟣🟣🟣🟣

    Citrate (6c)
    🔴🔴 🟣🟣🟣🟣
    Step 2

    Citrate(6c) is rearranged into


    iso-citrate(6c).
    The enzyme Aconitase
    facilitates this change
    Citrate (6c)

    Aconitase

    Iso-citrate (6c)
    Step 3

    Iso-citrate (6c) is oxidized by the enzyme


    iso-citrate dehydrogenase and loses a
    carbon dioxide molecule, forming alpha-
    ketoglutarate (5 carbons). This step
    produces NADH.
    Step 4
    Alpha-ketoglutarate(5c) undergoes
    another oxidation by the enzyme Alpha-
    ketoglutarate Dehydrogenase ,
    releasing another CO2 and forming
    succinyl-CoA (4 carbons). Another NADH
    is produced
    Step 5
    The Succinyl CoA(4c) is converted
    into Succinate (4c)
    by the enzyme Succinyl CoA
    Dehydrogenase, generating a
    molecule of ATP (or GTP).
    ADP ATP
    Step 6

    Succinate(4c) is converted into


    Fumrate(4c) by the enzyme
    Succinate Dehydrogenase. This
    reaction produces FADH2
    Step 7
    Step 7

    Fumrate(4c) is then converted


    into malate(4c) by adding water
    and this catalyzed by the enzyme
    fumrase.
    Step 8
    Malate(4c) is oxidized back to
    oxaloacetate(4c) by the enzyme
    Malate Dehydrogenase, completing
    the cycle. This step produces another
    NADH.
    2xCO2
    3xNADH
    1xFADH2
    1xATP
    What is the role of
    oxygen in cellular
    respiration?
    Oxygen plays a crucial role in respiration as it is
    the final electron acceptor in the electron
    transport chain. This process occurs in the
    mitochondria and produces ATP. Without the
    oxygen, respiration cannot proceed efficiently
    and cells may resort to anaerobic respiration,
    which produces less ATP. Oxygen also plays a
    role in the initial step of respiration, where it is
    used to break down glucose in glycolysis.
    Jingle of
    Group 5
    Krebs Krebs Krebs Cycle
    Oh let's learn about the
    Krebs Krebs Krebs Cycle
    This cycle is also known as as as as
    citric acid cycle oh Krebs cycle
    In the matrix, Acetyl CoA combines with Oxaloacetate
    to form a six carbon citrate
    Iso-citrate next and that will be the step 2
    3rd step the iso-citrate will
    oxidized to form alpha-keto
    4th step the alpha-keto will undergoes
    another oxidation releasing another CO2
    to form Succinyl CoA, alright
    Oh, let's learn about the Krebs Krebs Krebs
    Cycle
    The process of the Krebs Krebs Krebs cycle The
    products of the Krebs Krebs Krebs Cycle
    has 8 step in total oh Krebs cycle
    Oh let's learn about the Krebs Krebs Krebs cycle
    the process of the Krebs Krebs Krebs cycle the
    products of the Krebs Krebs Krebs cycle
    also called as citric acid cycle
    Oh Krebs Cycle
    The fifth step is Succinyl CoA and
    converted into 4 carbon molecule
    and that is called Succinate and the
    Succinate is oxidized to form Fumarate
    The 7 step is Fumarate converted to Malate
    and the Malate is oxidized back to Oxaloacetate
    And this is the 8 step of Krebs Cycle or Citric Acid
    Cycle, Alright
    Thank you!

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