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    Kreb's Cycle

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    sreedevd33
    This document summarizes the Krebs cycle, also known as the citric acid cycle or tricarboxylic acid cycle. [1] The cycle occurs in mitochondria and is the central metabolic pathway that breaks down carbohydrates, fats, and proteins into acetyl-CoA. [2] Acetyl-CoA then enters the Krebs cycle where it undergoes a series of chemical reactions, catalyzed by enzymes, to release energy through oxidation of acetyl groups and the production of carbon dioxide. [3] The cycle is highly exergonic and produces reduced co-enzymes that are used in the electron transport chain to generate ATP through oxidative phosphorylation.

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    Kreb's Cycle

    Uploaded by

    sreedevd33
    21 views14 pages
    This document summarizes the Krebs cycle, also known as the citric acid cycle or tricarboxylic acid cycle. [1] The cycle occurs in mitochondria and is the central metabolic pathway that breaks down carbohydrates, fats, and proteins into acetyl-CoA. [2] Acetyl-CoA then enters the Krebs cycle where it undergoes a series of chemical reactions, catalyzed by enzymes, to release energy through oxidation of acetyl groups and the production of carbon dioxide. [3] The cycle is highly exergonic and produces reduced co-enzymes that are used in the electron transport chain to generate ATP through oxidative phosphorylation.

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    mba student materials

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    KREB’S CYCLE

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    This document summarizes the Krebs cycle, also known as the citric acid cycle or tricarboxylic acid cycle. [1] The cycle occurs in mitochondria and is the central metabolic pathway that breaks down carbohydrates, fats, and proteins into acetyl-CoA. [2] Acetyl-CoA then enters the Krebs cycle where it undergoes a series of chemical reactions, catalyzed by enzymes, to release energy through oxidation of acetyl groups and the production of carbon dioxide. [3] The cycle is highly exergonic and produces reduced co-enzymes that are used in the electron transport chain to generate ATP through oxidative phosphorylation.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    21 views14 pages

    Kreb's Cycle

    Uploaded by

    sreedevd33
    This document summarizes the Krebs cycle, also known as the citric acid cycle or tricarboxylic acid cycle. [1] The cycle occurs in mitochondria and is the central metabolic pathway that breaks down carbohydrates, fats, and proteins into acetyl-CoA. [2] Acetyl-CoA then enters the Krebs cycle where it undergoes a series of chemical reactions, catalyzed by enzymes, to release energy through oxidation of acetyl groups and the production of carbon dioxide. [3] The cycle is highly exergonic and produces reduced co-enzymes that are used in the electron transport chain to generate ATP through oxidative phosphorylation.

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    KREB’S CYCLE

    PRESENTED BY:
    ROBINA KHANOM
    B.Sc 5TH SEMESTER
    DEPARTMENT OF CHEMESTRY
     This conversion is catalyzed byba highly organized
    multienzyme pyruvate dehydraogenase complex.
     In the overall reaction, the carboxylic group of pyruvate is
    lost as co2, while the remaining 2 carbons from the acetyl
    moiety of acetyl- coA.
     The reaction is highly exergic and is essentially
    irreversible, in viva
    KREB’S CYCLE

    Citric acid cycle or Kreb’s cycle or Tricarboxylic acid (TCA)


    cycle :
     Citric acid cycle is a central metabolic pathway for
    metabolism of carbohydrates, fats and proteins. This cycle
    occurs in aerobic conditions in mitochondria. At first
    carbohydrates,fats and proteins are catabolized by
    separate pathway to from acetyl-coa, then acetyl-coa
    enter into citric acid cycle.
    STEP WISE EXPLAINATION OF THE CITRIC
    ACID/TRICARBOXYLIC/KREB'S CYCLE
    STEP1: Condensation OF Acetyl-CoA
    with Oxaloacetate
     The cycle begins with the condensation of a 4
    carbon unit, the oxaloacetate, and the acetyl
    group of the Acetyl CoA, which is a 2 carbon unit.
     Oxaloacetate reacts with Acetyl-CoA and H2O to
    yield citrate and CoA.
     This reaction is an aldol condensation reaction
    and is followed by hydrolysis.itis catalyzed by the
    enzyme: "citrate synthetase".
    STEP 2: ISOMERIZATION OF Citrate
    INTO Iso-citrate
     In this reaction, water is first removed and then added
    back, moves the hydroxyl group from one carbon atom to
    its neighbor.
     The enzyme catalyzing this reaction is aconitase.
    STEP 3: Oxidative Decarboxylation of
    Isocitrate

     Isocitrate is oxidized and decarboxylated into a-


    ketoglutarate
     This reaction is catalyzed by the enzyme "isocitrate
    dehydrogenase."
    STEP 4: Oxidative decarboxylation of
    a-ketogluterate
     This second oxidative decarboxylation results in
    formation of "Succinyl CoA" from a-ketogluterate.
     "a-ketogluterate dehydrogenase" catalyzes this oxidative
    step and produces NADH, CO2 and a high- energy thioester
    bond to coenzyme-A (COA)
    STEP 5: Conversion of Succinyl-CoA
    into Succinate
     The cleavage of the thioester bond of Succinyl-CoA is
    coupled to the phosphorylation of a purine nucleoside
    diphosphate, usually GDP (substtrate level
    phosphorylation).
     It is catalyzed by "succinyl CoA synthetase/ succinyl
    thiokinase".•
     This is the only step in the Kreb's Cycle that directly
    yields a compound with high phosphoryk transfer potential
    through a substrate level phosphorylation
    Thank you

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