Keith_Yamamoto

Keith Yamamoto
Keith R. Yamamoto (born February 4, 1946) is vice

chancellor of Science Policy and Strategy and Keith R. Yamamoto
professor of Cellular and Molecular Pharmacology at
the University of California, San Francisco, (UCSF).
He is known for his Molecular Biology and
Biochemistry research on nuclear receptors and his
involvement in science policy and precision medicine.
Yamamoto identified the genomic sequences to which

the glucocorticoid receptor (GR) binds in order to
control gene transcription[1] termed "glucocorticoid
response elements".[2] In science policy, he has served
as Chairman of the Board on Life Sciences at the
National Academy of Sciences,[3] as well as serving on
numerous government and public advisory boards,
including the NIH Center for Scientific Review
Advisory Council. Born February 4, 1946
Des Moines, Iowa,
United States
Research career Alma mater Iowa State University, Princeton

University
Yamamoto was born in Des Moines, Iowa, and Scientific career
graduated from Iowa State University with a B.S. in Fields Biochemistry
Biochemistry and Biophysics in 1968. At Iowa State,
Institutions University of California, San
he was a member of the Delta Upsilon fraternity.[4] He
Francisco
earned his doctorate in Biochemical Sciences at
Princeton University in 1973 in the laboratory of Bruce
Alberts for his research on the estrogen receptor (ER).[5] He then began his research on the glucocorticoid
receptor as a postdoctoral fellow with Gordon Tomkins at UCSF.
In 1976, Yamamoto joined the Department of Biochemistry and Biophysics at the University of
California, San Francisco (UCSF) as an Assistant Professor. In 1978, he became an associate professor
and in 1983 a full professor. He also took on the role of Vice-Chair of the Department of Biochemistry
and Biophysics at UCSF in 1985. In 2015, Yamamoto became UCSF's first vice chancellor of science
policy and strategy. He was previously the vice chancellor of research for the university, and the vice
dean, Research, within the School of Medicine.
Yamamoto was elected a fellow of the American Academy of Arts and Sciences in 1989,[6] elected to the
National Academy of Sciences in 1989, and to the American Association for the Advancement of Science
in 2002. Yamamoto ran a research lab focused on understanding signaling and transcriptional control by
nuclear receptors and continues to teach graduate courses in molecular biology and biochemistry at
UCSF.
Political career
Throughout his career, Dr. Yamamoto has also been committed to public and science policy. In the 1980s
he argued against the development of biological warfare by the U.S. Department of Defense.[7][8] In 1986
he co-authored with Charles Piller a book, "The Rebirth of American Biological Warfare:GENE WARS
Military Control Over the New Genetic Technologies", disclosing the history of the use of biological
weapons in the United States and advising against continuing these programs.[9]
Dr. Yamamoto has served on several committees that oversee the NIH peer review process which
allocates funding to research investigators. He was Chairman of the NIH Center for Scientific Review
Advisory Committee from 1996-2000. From 2007-2008 he co-chaired The Advisory Committee to the
Director Working Group on Peer Review and the Advisory Committee to the NIH Director from 2007-
2010. He had advocated for streamlining the science grant review process and for devising strategies for
focusing NIH funding on research that will have the greatest impact in the field.[10] In 2008, he was
nominated as one of 10 Influential People to Watch in Biomedical Policy.[3]
In April 2022, Dr. Yamamoto was elected as President of the American Association of the Advancement
of Science (AAAS), the largest multidisciplinary scientific society in the world.
Publications
Research publications at Pubmed (https://www.ncbi.nlm.nih.gov/pubmed?term=Yamamoto%20KR%5B
Author%5D&cauthor=true&cauthor_uid=206732)
References
1. Ucker, DS; Ross, SR; Yamamoto, KR (December 1981). "Mammary tumor virus DNA
contains sequences required for its hormone regulated transcription". Cell. 27 (2 Part 1):
257–266. doi:10.1016/0092-8674(81)90409-8 (https://doi.org/10.1016%2F0092-8674%288
1%2990409-8). PMID 6277499 (https://pubmed.ncbi.nlm.nih.gov/6277499).
S2CID 37961743 (https://api.semanticscholar.org/CorpusID:37961743).
2. Chandler, VL; Maler, BA; Yamamoto; KR (June 1983). "DNA sequences bound specifically
by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in
vivo". Cell. 33 (2): 489–499. doi:10.1016/0092-8674(83)90430-0 (https://doi.org/10.1016%2
F0092-8674%2883%2990430-0). PMID 6190571 (https://pubmed.ncbi.nlm.nih.gov/619057
1).
3. Schubert, Charlotte (2008). "10 influential people to watch in biomedical policy". Nature
Medicine. 14 (10): 1004–1005. doi:10.1038/nm1008-1004 (https://doi.org/10.1038%2Fnm10
08-1004). S2CID 38846080 (https://api.semanticscholar.org/CorpusID:38846080).
4. Bomb Yearbook. Ames, Iowa: Iowa State University of Science and Technology. 1968.
p. 200.
5. Yamamoto, Keith; Bruce Alberts (1 August 1972). "In vitro conversion of estradiol-receptor
protein to its nuclear form: dependence on hormone and DNA" (https://www.ncbi.nlm.nih.go
v/pmc/articles/PMC426878). Proc. Natl. Acad. Sci. 69 (8): 2105–2109.
Bibcode:1972PNAS...69.2105Y (https://ui.adsabs.harvard.edu/abs/1972PNAS...69.2105Y).
doi:10.1073/pnas.69.8.2105 (https://doi.org/10.1073%2Fpnas.69.8.2105). PMC 426878 (htt
ps://www.ncbi.nlm.nih.gov/pmc/articles/PMC426878). PMID 4506080 (https://pubmed.ncbi.n
lm.nih.gov/4506080).
6. "Book of Members, 1780-2010: Chapter XYZ" (https://www.amacad.org/sites/default/files/m
edia/document/2019-10/ChapterXYZ.pdf) (PDF). American Academy of Arts and Sciences.
Retrieved 14 April 2022.
7. Croddy, Eric (1997). Chemical and Biological Warfare: An Annotated Bibliography.
Maryland: Scarecrow Press. p. 124.
8. Yamamoto, Keith R. (August 1989). "Retargeting Research on Biological Weapons".
Technology Review: 23–24.
9. Kelves, Daniel (8 May 1988). "The Rebirth of American Biological Warfare : GENE WARS
Military Control Over the New Genetic Technologies by Charles Piller and Keith R.
Yamamoto" (https://www.latimes.com/archives/la-xpm-1988-05-08-bk-3620-story.html). Los
Angeles Times.
10. Pfeffer, Suzanne (February 2011). "The Yamamoto Plan" (http://www.asbmb.org/asbmbtoda
y/asbmbtoday_article.aspx?id=11326&page_id=1). ASBMB Today.
External links
Keith Yamamoto's Short Talk: "Taking Risks" (https://www.ibiology.org/professional-develop
ment/taking-risks-in-science/)
Yamamoto Lab website (http://yamamotolab.ucsf.edu/)
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Keith Yamamoto

Keith R. Yamamoto (born February 4, 1946) is vice

Yamamoto identified the genomic sequences to which

Research career Alma mater Iowa State University, Princeton

Retrieved from "https://en.wikipedia.org/w/index.php?title=Keith_Yamamoto&oldid=1247892171"

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