The

Integumentary
System
PRESENTED BY:
SIR JOHN HECTOR B. DE VERA, RPh
Body Membranes
• Functions of body membranes
• Cover body surfaces
• Line body cavities
• Form protective sheets around organs
• Classified according to tissue types
Body Membranes
• Epithelial membranes
• Cutaneous membranes
• Mucous membranes
• Serous membranes
• Connective tissue membranes
• Synovial membranes
Epithelial Membranes
• Epithelial membranes are simple organs
• Also called covering and lining membranes
• These membranes contain:
• Epithelial tissue layer
• Connective tissue layer
Epithelial Membranes
• Cutaneous membrane = skin
• Dry membrane
• Outermost protective boundary
• Construction
• Epidermis is composed of keratinized stratified squamous
epithelium
• Dermis is mostly dense (fibrous) connective tissue
Figure 4.1a Classes of epithelial membranes.

Cutaneous
membrane
(skin)

(a) Cutaneous membrane (the skin)

covers the body surface.

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Epithelial Membranes
• Mucous membranes (mucosae)
• Moist membranes
• Line all body cavities that open to the exterior body
surface
• Adapted for absorption or secretion
• Construction
• Epithelium type depends on site
• Loose connective tissue (lamina propria)
Figure 4.1b Classes of epithelial membranes.

Mucosa

(b) Mucous membranes line body cavities

open to the exterior.
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Epithelial Membranes
• Serous membranes (serosae)
• Line open body cavities that are closed to the exterior of
the body
• Occur in pairs, separated by serous fluid, with a visceral
and parietal layer
• Construction
• Simple squamous epithelium
• Areolar connective tissue
Figure 4.1c Classes of epithelial membranes.

Parietal layer
Serous fluid
Visceral layer

(c) Serous membranes line body cavities closed to exterior.

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Figure 4.1d Classes of epithelial membranes.

Outer balloon wall

(comparable to parietal serosa)
Air (comparable to serous cavity)
Inner balloon wall
(comparable to visceral serosa)
(d) A fist thrust into a limp balloon demonstrates
the relationship between the parietal and
visceral serous membrane layers.

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Epithelial Membranes
• Specific serous membranes
• Peritoneum
• Abdominal cavity
• Pleura
• Around the lungs
• Pericardium
• Around the heart
Connective Tissue Membranes
• Synovial membranes
• Loose areolar connective tissue only (no epithelial tissue)
• Line fibrous capsules surrounding joints
• Line bursae
• Line tendon sheaths
• Secrete a lubricating fluid to cushion organs moving
against each other during muscle activity
Figure 4.2 A typical synovial joint

Ligament

Joint cavity
(contains
synovial fluid)
Articular (hyaline)
cartilage

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Integumentary System
• Integumentary system consists of the:
• Skin (cutaneous membrane)
• Skin appendages
• Sweat glands
• Oil glands
• Hair
• Nails
Functions of the Integumentary
System
• Insulates and cushion deeper body organs
• Protects the entire body from:
• Mechanical damage (bumps and cuts)
• Chemical damage (acids and bases)
• Thermal damage (heat or cold)
• Ultraviolet (UV) radiation (sunlight)
• Microbes (bacteria)
• Desiccation (drying out)
Functions of the Integumentary
System
• Aids in loss or retention of body heat as controlled by
the nervous system
• Aids in excretion of urea and uric acid
• Synthesizes vitamin D
Table 4.1 Functions of the Integumentary System (1 of 2)

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Structure of the Skin
• Two kinds of tissue compose the skin
• Epidermis
• Dermis
• Hypodermis (subcutaneous layer)
• Anchors the skin to underlying organs
• Not technically part of the integumentary system
• Composed mostly of adipose tissue
• Serves as a shock absorber and insulates deeper tissues
Structure of the Skin
• Epidermis—outer layer
• Capable of being hard and tough
• Stratified squamous epithelium
• Keratinocytes (the most common cell) produce a fibrous
protein called keratin
• Avascular
• Composed of five layers (strata)
Structure of the Skin
• Summary of layers of the epidermis from deepest to
most superficial
• Stratum basale
• Stratum spinosum
• Stratum granulosum
• Stratum lucidum (thick, hairless skin only)
• Stratum corneum
Structure of the Skin
• Stratum basale (stratum germinativum)
• Deepest layer of epidermis
• Lies next to dermis
• Wavy borderline with the dermis anchors the two together
• Cells undergoing mitosis
• Daughter cells are pushed upward to become the more
superficial layers
• Stratum spinosum
• Cells become increasingly flatter and more keratinized
Structure of the Skin
• Stratum granulosum
• Stratum lucidum
• Formed from dead cells of the deeper strata
• Occurs only in thick, hairless skin of the palms of hands
and soles of feet
• Stratum corneum
• Outermost layer of epidermis
• Shingle-like dead cells are filled with keratin (protective
protein prevents water loss from skin)
Structure of the Skin
• Melanin
• Melanin is a pigment produced by melanocytes
• Melanocytes are mostly in the stratum basale of the
epidermis
• Color is yellow to brown to black
• Melanin accumulates in membrane-bound granules called
melanosomes
• Amount of melanin produced depends upon genetics and
exposure to sunlight
Structure of the Skin
• Epidermal dendritic cells
• Alert and activate immune cells to a threat (bacterial or
viral invasion)
• Merkel cells
• Associated with sensory nerve endings
• Serve as touch receptors called Merkel discs
Structure of the Skin
• Dermis
• Connective tissue
• Underlies the epidermis
Structure of the Skin
• Two layers of the dermis
• Papillary layer (upper dermal region) contain projections
called dermal papillae
• Indent the epidermis above
• Many projections contain capillary loops, and others house
pain and touch receptors
• On palm and sole surfaces, papillae increase friction and
gripping ability
• Fingerprints are identifying films of sweat
Structure of the Skin
• Two layers of the dermis (continued)
• Reticular layer (deepest skin layer)
• Blood vessels
• Sweat and oil glands
• Deep pressure receptors (lamellar corpuscles)
Figure 4.5 Light micrograph of the two layers of the dermis (100X).

Epidermis

Papillary
layer

Dermis

Reticular
layer

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Structure of the Skin
• Other dermal features
• Cutaneous sensory receptors
• Phagocytes
• Collagen and elastic fibers
• Blood vessels
Skin Color
• Three pigments contribute to skin color
1.Melanin
• Yellow, reddish brown, or black pigments
2.Carotene
• Orange-yellow pigment from some vegetables
3.Hemoglobin
• Red coloring from blood cells in dermal capillaries
• Oxygen content determines the extent of red coloring
Skin Color
• Redness (erythema)—due to embarrassment,
inflammation, hypertension, fever, or allergy
• Pallor (blanching)—due to emotional stress (such as
fear), anemia, low blood pressure, impaired blood
flow to an area
• Jaundice (yellow cast)—indicates a liver disorder
• Bruises (black and blue marks)—hematomas
Appendages of the Skin
• Cutaneous glands are all exocrine glands
• Sebaceous glands
• Sweat glands
• Hair
• Hair follicles
• Nails
Appendages of the Skin
• Sebaceous (oil) glands
• Located all over the skin except for palms and soles
• Produce sebum (oil)
• Makes skin soft and moist
• Prevents hair from becoming brittle
• Kills bacteria
• Most have ducts that empty into hair follicles; others
open directly onto skin surface
• Glands are activated at puberty
Figure 4.6a Cutaneous glands.
Sweat
pore

Sebaceous Eccrine
gland gland

Sebaceous
gland duct

Dermal connective
tissue

Hair in
hair follicle

Secretory cells

(a) Photomicrograph of a sectioned

sebaceous gland (100×)
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Appendages of the Skin
• Sweat (sudoriferous) glands
• Produce sweat
• Widely distributed in skin
• Two types of sudoriferous glands
1.Eccrine glands
2.Apocrine glands
Appendages of the Skin
• Eccrine glands
• Open via duct to sweat pores on the skin’s surface
• Produce acidic sweat
• Water, salts, vitamin C, traces of metabolic waste
• Function in body temperature regulation
Figure 4.6b Cutaneous glands.
Sweat
pore

Eccrine
Sebaceou
gland
s
gland

Dermal connective
tissue

Eccrine
gland duct

Secretory cells

(b) Photomicrograph of a
sectioned eccrine
gland (205×)
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Appendages of the Skin
• Apocrine glands
• Ducts empty into hair follicles in the armpit and genitals
• Begin to function at puberty
• Release sweat that also contains fatty acids and proteins
(milky or yellowish color)
• Play a minimal role in body temperature regulation
Appendages of the Skin
• Hair
• Produced by hair follicle
• Root is enclosed in the follicle
• Shaft projects from the surface of the scalp or skin
• Consists of hard keratinized epithelial cells
• Melanocytes provide pigment for hair color
• Hair grows in the matrix of the hair bulb in stratum basale
Figure 4.7a Structure of a hair root and follicle.

Hair
shaft

Arrector
pili muscle

Sebaceous
gland
Hair follicle
Hair root

Hair bulb
in follicle

(a) Hair in hair follicle

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Appendages of the Skin
• Hair anatomy
• Central medulla
• Cortex surrounds medulla
• Cuticle on outside of cortex
• Most heavily keratinized region of the hair
Figure 4.7b Structure of a hair root and follicle.

Cuticle
Cortex
Medulla

(b) Hair

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Figure 4.7c Structure of a hair root and follicle.

(c) Scanning electron micrograph

of hair shaft emerging from
follicle (435×)

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Appendages of the Skin
• Associated hair structures
• Hair follicle
• Composed of an epithelial root sheath and fibrous sheath
• Dermal region provides a blood supply to the hair bulb
(deepest part of the follicle)
• Arrector pili muscle connects to the hair follicle to pull hairs
upright when we are cold or frightened
Figure 4.7d Structure of a hair root and follicle.
Hair root

Fibrous
sheath (dermal
connective Cuticle
tissue)
Hair Cortex
follicle
Epithelial
Medulla
root sheath

Hair matrix (growth

zone) in hair bulb

Melanocyte

Hair papilla
containing
blood vessels
Subcutaneous
adipose tissue

(d) Cross section of hair bulb

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Appendages of the Skin
• Nails
• Heavily keratinized, scalelike modifications of the
epidermis
• Stratum basale extends beneath the nail bed, which is
responsible for growth
• Lack of pigment makes nails colorless
Appendages of the Skin
• Parts of a nail
• Free edge
• Body is the visible attached portion
• Nail folds are skin folds that overlap the edges of the nail;
the cuticle is the proximal edge
• Root of nail is embedded in skin
• Growth of the nail occurs from nail matrix
Figure 4.8 Structure of a nail.
Lunule Lateral
nail fold

(a)

Free edge Body Cuticle Root of nail

of nail of nail
Proximal Nail
nail fold matrix

(b) Nail bed Bone of fingertip

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Homeostatic Imbalances of Skin
• Infections and allergies
• Athlete’s foot
• Caused by fungal infection (Tinea pedis)
• Itchy, red peeling skin between the toes
• Boils (furuncles) and carbuncles
• Caused by inflammation of hair follicles
• Carbuncles are clusters of boils caused by bacteria
• Cold sores (fever blisters)
• Caused by human herpesvirus 1
• Blisters itch and sting
Homeostatic Imbalances of Skin
• Infections and allergies (continued)
• Contact dermatitis
• Caused by exposure to chemicals that provoke
allergic responses
• Itching, redness, and swelling of the skin
• Impetigo
• Caused by bacterial infection
• Pink, fluid-filled raised lesions around mouth/nose
• Psoriasis
• Triggered by trauma, infection, hormonal changes,
or stress
• Red, epidermal lesions covered with dry, silvery
scales that itch, burn, crack, or sometimes bleed
Homeostatic Imbalances of Skin
• Burns
• Tissue damage and cell death caused by heat, electricity,
UV radiation, or chemicals
• Associated dangers
• Protein denaturation and cell death
• Dehydration and electrolyte imbalance
• Circulatory shock
• Result in loss of body fluids and infection from the
invasion of bacteria
Homeostatic Imbalances of Skin
• Extent of a burn is estimated using the rule of nines
• Body is divided into 11 areas for quick estimation
• Each area represents about 9 percent of total body
surface area
• The area surrounding the genitals (the perineum) represents 1
percent of body surface area
Figure 4.10a Burns.

Totals
41 2 %
Anterior and posterior
head and neck, 9%

Anterior and posterior

upper limbs, 18%

Anterior and posterior

41 2 % 41 2 % trunk, 36%
Anterior
trunk, 18%

Perineum, 1%
9% 9%

Anterior and posterior

lower limbs, 36%

100%
(a) Rule of nines
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Homeostatic Imbalances of Skin
• First-degree burn (superficial burn)
• Only epidermis is damaged
• Skin is red and swollen
• Second-degree burn (partial-thickness burn)
• Epidermis and superficial part of dermis are damaged
• Skin is red, painful, and blistered
• Regrowth of the epithelium can occur
Homeostatic Imbalances of Skin
• Third-degree burn (full-thickness burn)
• Destroys epidermis and dermis; burned area is painless
• Requires skin grafts, as regeneration is not possible
• Burned area is blanched (gray-white) or black
• Fourth-degree burn (full-thickness burn)
• Extends into deeper tissues (bone, muscle, tendons)
• Appears dry and leathery
• Requires surgery and grafting
• May require amputation
Figure 4.10b Burns.

(b) Examples of burns

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Homeostatic Imbalances of Skin
• Criteria for deeming burns critical (if any
one is met):
• Over 30 percent of body has second-degree
burns
• Over 10 percent of the body has third- or
fourth-degree burns
• Third- or fourth-degree burns of the face,
hands, or feet, or genitals
• Burns affect the airways
• Circumferential (around the body or limb)
burns have occurred
Homeostatic Imbalances of Skin
• Skin cancer
• Most common form of cancer in humans
• Most important risk factor is overexposure to ultraviolet
(UV) radiation in sunlight and tanning beds
• Cancer can be classified two ways
1.Benign means the neoplasm (tumor) has not spread
2.Malignant means the neoplasm has invaded other body
areas
Homeostatic Imbalances of Skin
• Most common types of skin cancer
• Basal cell carcinoma
• Squamous cell carcinoma
• Malignant melanoma

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Homeostatic Imbalances of Skin
• Basal cell carcinoma
• Least malignant and most common type of skin cancer
• Arises from cells in stratum basale that are altered so that
they can no longer make keratin
• Lesions appear as shiny, dome-shaped nodules that
develop a central ulcer
Figure 4.11a Photographs of skin cancers.

(a) Basal cell carcinoma

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Homeostatic Imbalances of Skin
• Squamous cell carcinoma
• Believed to be induced by UV exposure
• Arises from cells of stratum spinosum
• Lesions appear as scaly, reddened papules that gradually
form shallow ulcers
• Early removal allows a good chance of cure
• Metastasizes to lymph nodes if not removed
Figure 4.11b Photographs of skin cancers.

(b) Squamous cell carcinoma

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Homeostatic Imbalances of Skin
• Malignant melanoma
• Most deadly of skin cancers, but accounts for only 5
percent of skin cancers
• Arises from melanocytes
• Metastasizes rapidly to lymph and blood vessels
• Detection uses ABCDE rule for recognizing melanoma
Homeostatic Imbalances of Skin
• Malignant melanoma (continued)
• A = Asymmetry
• Two sides of pigmented mole do not match
• B = Border irregularity
• Borders of mole are not smooth
• C = Color
• Different colors in pigmented area
• D = Diameter
• Spot is larger than 6 mm in diameter
• E = Evolution
• One or more of the ABCD characteristics is evolving
Figure 4.11c Photographs of skin cancers.

(c) Melanoma
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Developmental Aspects of Skin and
Body Membranes
• Lanugo, a downy hair, covers the body by the fifth or
sixth month of fetal development but disappears by
birth
• Vernix caseosa, an oily covering, is apparent at birth
• Milia, small white spots, are common at birth and
disappear by the third week
• Acne may appear during adolescence
Developmental Aspects of Skin and
Body Membranes
• In youth, skin is thick, resilient, and well hydrated
• With aging, skin loses elasticity and thins
• Skin cancer is a major threat to skin exposed to
excessive sunlight
• Balding and/or graying occurs with aging; both are
genetically determined; other factors that may
contribute include drugs and emotional stress