2011 Faseb SRC Program 1-3-11

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2011 FASEB Summer Research Conferences Proteases in Hemostasis and Vascular Biology June 12-17, 2011 Carefree, Arizona

Co-Organizers: Jay Degen Cincinnati Childrens Hospital / University of Cincinnati Cincinnati, OH James Huntington University of Cambridge Cambridge, UK

Sunday, June 12, 2011


4:00PM 9:00PM 6:00PM 7:00 PM 7:00PM 8:30 PM 8:30PM 10:00PM FASEB Office open for Registration FASEB Opening Reception Buffet Dinner Keynote Speakers Sidney Strickland Rockefeller University Fibrin and Alzheimers Disease: The Clot Thickens Russell F. Doolittle University of California, San Diego, CA Evolving insights in coagulation

Monday, June 13, 2011


7:30AM 9:00AM Session 1: 9:00AM 12:00PM Breakfast Platelet Activation, Endothelial Cells and the EC Interface Chair: Paula Tracy, University of Vermont Welcome to FASEB Skip Brass, University of Pennsylvania Novel regulators of platelet activation Leslie Parise, UNC Chapel Hill Platelet activation mechanisms and sickle cell disease TBN Hot Topic selected from submitted abstracts FASEB Sponsored Coffee Break & Group Photo Mark Ginsberg, University of California, San Diego Endothelial cell-cell junctions and vascular permeability Mark Kahn, University of Pennsylvania Platelet signaling and the regulation of lymphatic vascular development Lunch

9:00AM 9:10AM 9:10AM 9:40AM

9:40AM - 10:10AM

10:10AM 10:25AM (15 min) 10:30AM 11:00 AM 11:00AM 11:30AM

11:30AM 12:00PM

12:00PM 1:00PM Free Time 3:00PM 4:00PM

Meet-the-Expert Session: Things you wish someone told you earlier about grants Poster Session 1 Dinner Biochemistry and Cell Biology of Proteases, Receptors and Inhibitors Chair: Steven Olson, University of Illinois James Huntington, Cambridge University Protease and Serpin Contortionism Paul Bock, Vanderbilt University Bacterial activators of prothrombin and plasminogen TBN Hot Topic selected from submitted abstracts Break Rodney Camire, CHOP/University of Pennsylvania Basic and translational advances along the common pathway TBN

4:00PM 6:00PM 6:00PM 7:00PM Session 2: 7:00PM 10:00PM

7:00PM - 7:30PM

7:30PM 8:00PM

8:00PM 8:15PM (15 min) 8:15PM 9:00PM 9:00PM 9:30PM

9:30PM 10:00PM

Tuesday, June 14, 2011


7:30AM 9:00AM Session 3: 9:00AM 12:00PM Breakfast Novel Protease Systems and Mechanisms Coupling Proteases to Disease Chair: Thomas Bugge, NIH/NIDCR Toni Antalis, University of Maryland Membrane-associated serine proteases Stephen Weiss, University of Michigan Membrane-associated MMP in development and disease TBN Hot Topic selected from submitted abstracts FASEB Sponsored Coffee Break Thomas Bugge, NIH/NIDCR Matriptase-mediated pro-HGF activation in squamous cell carcinoma Joseph Palumbo, University of Cincinnati, CCHMC Regulation of proteases at the endothelial cell-tumor cell interface in metastasis Lunch

9:00AM - 9:35AM

9:35PM 10:05AM

10:05AM 10:20AM (15 min) 10:20AM 11:00AM 11:00AM 11:30AM

11:30AM 12:00PM

12:00PM 1:00PM Afternoon free for activities 6:00PM 7:00PM 7:00PM 8:00PM

Dinner Stuart Stone Lecture Sriram Krishnaswamy, Childrens Hospital of Philadelphia Dissection of the Continuum: Prothrombin activation and the fate/function of thrombin intermediates fXIII- and fXI-dependent events in vivo Chair: David Gailani, Vanderbilt University Andras Gruber, Oregon Health and Science Role of proteases factor XII and XI in pathological events Break TBN Hot Topic selected from submitted abstracts Thomas Renn, Karolinska Institutet Roles of factor XII for coagulation and inflammation

Session 4: 8:00PM 10:00PM

8:00PM - 8:35PM

8:35PM 9:10PM 9:10PM 9:25PM (15 min) 9:25PM 10:00PM

Wednesday, June 15, 2011


7:30AM 9:00AM Breakfast

Session 5: 9:00AM 12:00PM

Proteases and vascular biology Chair: Patricia Andrade-Gordon, Johnson & Johnson JoAnn Trejo, University of California, San Diego Mechanisms underlying differential protease signaling through PARs TBN TBN Hot Topic selected from submitted abstracts FASEB Sponsored Coffee Break Nigel Mackman, UNC Chapel Hill TF- and PAR-mediated events in vivo Hugo ten Cate, Maastricht University Thrombin and thrombomodulin in vessel wall disease Lunch

9:00AM - 9:35AM

9:35PM 10:10AM 10:10AM 10:25AM (15 min) 10:25AM 10:50AM 10:50AM 11:25AM

11:25AM 12:00PM

12:00PM 1:00PM Free Time 4:00PM 6:00PM 6:00PM 7:00PM 7:00PM 7:15PM Session 6: 7:15PM 10:00PM

Poster Session 2 Dinner Business Meeting Integrated Systems Controlling Vascular Permeability Chair: Shaun Coughlin, UCSF Shaun Coughlin, UCSF Control inflammation-induced vascular permeability Wolfram Ruf, Scripps Research Institute TF activation and cell signaling Li Zhang, University of Maryland APC signaling and integrin CD11b Break TBN Hot Topic selected from submitted abstracts TBN

7:15PM - 7:45PM

7:45PM 8:15PM

8:15PM 8:45PM

8:45PM 9:15PM 9:15PM 9:30PM (15 min) 9:30PM 10:00PM

Thursday, June 16, 2011


7:00AM 9:00AM Session 7: 9:00AM 12:00PM Breakfast Proteases in Inflammation and Host Defense Chair: Hartmut Weiler, Blood Center of Wisconsin

9:00AM - 9:35AM

Hartmut Weiler, Blood Center of Wisconsin Regulation of inflammatory systems by activated Protein C TBN TBN Hot Topic selected from submitted abstracts FASEB Sponsored Coffee Break Matthew Flick, University of Cincinnati, CCHMC Engineered forms of pro/thrombin and inflammatory disease TBN Lunch

9:35AM 10:10AM 10:10AM 10:25AM (15 min) 10:25AM 10:50AM 10:50AM 11:25AM

11:25AM 12:00PM 12:00PM 1:00PM Afternoon free for activities 6:00PM 7:00PM Session 8: 7:00PM 10:00PM

Dinner Protease Engineering and Therapeutics Chair: Charles Craik, UCSF Edwin Madison, Catalyst Biosciences Redirection of protease specificity to therapeutically significant targets TBN Hot Topic selected from submitted abstracts Jeffrey Weitz, McMaster University, Canada Therapeutic advances in the arms race for fIIa- and fXa-targeted anticoagulants Break TBN Katherine High, University of Pennsylvania/HHMI Realizing the vision of gene therapy

7:00PM - 7:35PM

7:35PM 7:50PM (15 min) 7:50PM 8:25PM

8:25PM 8:50PM 8:50PM 9:25PM 9:25PM 10:00PM

Friday, June 17, 2011


7:30AM 8:30AM Session 9: 9:00AM 12:00PM Breakfast Proteases Targets in Neurobiology Chair: Katerina Akassoglou, Gladstone, UCSF Katerina Akassoglou, Gladstone, UCSF Hemostatic factors in CNS inflammatory disease TBN FASEB Sponsored Coffee Break Daniel Lawrence, University of Michigan

9:00AM - 9:35AM

9:35AM 10:00AM 10:00AM 10:25AM 10:25AM 11:00AM

Protease action in the neurovascular unit and stroke 11:00AM 11:05AM 12:00PM Closing Comments Departure Boxed Lunches Available END OF CONFERENCE For additional information contact: FASEB Summer Research Conferences 9650 Rockville Pike Bethesda, MD 20814 Arizona@faseb.org http://src.faseb.org

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