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    PHS 3505 - Outline - 12

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    Sohil Jain
    This document outlines the course description, requirements, and schedule for PHS 3505 Clinical Immunology taught by Dr. F.A. Barile during the Summer Session I of 2012. The course examines the principles of the human immune system and focuses on antibody-antigen relationships, the immune response, and immunopathology. Students will be evaluated based on two two-hour exams, a midterm and a final, which will each contribute 50% to the final grade. The course will cover topics such as innate and acquired immunity, immunogens, antibody structure and function, antigen-antibody interactions, hypersensitivity reactions, immunodeficiencies, and immunotherapy over 13 classes.

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    PHS 3505 - Outline - 12

    Uploaded by

    Sohil Jain
    78 views3 pages
    This document outlines the course description, requirements, and schedule for PHS 3505 Clinical Immunology taught by Dr. F.A. Barile during the Summer Session I of 2012. The course examines the principles of the human immune system and focuses on antibody-antigen relationships, the immune response, and immunopathology. Students will be evaluated based on two two-hour exams, a midterm and a final, which will each contribute 50% to the final grade. The course will cover topics such as innate and acquired immunity, immunogens, antibody structure and function, antigen-antibody interactions, hypersensitivity reactions, immunodeficiencies, and immunotherapy over 13 classes.

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    This document outlines the course description, requirements, and schedule for PHS 3505 Clinical Immunology taught by Dr. F.A. Barile during the Summer Session I of 2012. The course examines the principles of the human immune system and focuses on antibody-antigen relationships, the immune response, and immunopathology. Students will be evaluated based on two two-hour exams, a midterm and a final, which will each contribute 50% to the final grade. The course will cover topics such as innate and acquired immunity, immunogens, antibody structure and function, antigen-antibody interactions, hypersensitivity reactions, immunodeficiencies, and immunotherapy over 13 classes.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    78 views3 pages

    PHS 3505 - Outline - 12

    Uploaded by

    Sohil Jain
    This document outlines the course description, requirements, and schedule for PHS 3505 Clinical Immunology taught by Dr. F.A. Barile during the Summer Session I of 2012. The course examines the principles of the human immune system and focuses on antibody-antigen relationships, the immune response, and immunopathology. Students will be evaluated based on two two-hour exams, a midterm and a final, which will each contribute 50% to the final grade. The course will cover topics such as innate and acquired immunity, immunogens, antibody structure and function, antigen-antibody interactions, hypersensitivity reactions, immunodeficiencies, and immunotherapy over 13 classes.

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    PHS 3505 Clinical Immunology, SSI 2012

    Dr. F.A. Barile, Ph.D., R.Ph.

    PHS 3505: Clinical Immunology Dr. F.A. Barile, Ph.D., R.Ph.


    Professor of Pharmaceutical Sciences

    SSI 2012
    Office: St. Alberts Hall, B63 barilef@stjohns.edu

    1. COURSE DESCRIPTION This course examines the principles of the immune system, including the immune response and principles of immunity in humans. Principles of antibodyantigen relationship are discussed. Special emphasis is placed on the biology of the immune response and the mechanisms controlling antibody synthesis, its development and function. Immununopathology, immunoserology and immunotherapy are also incorporated. 2. TEXT: Immunology: A short course, Coico & Sunshine, 6th edition, Wiley-Blackwell Publishers, 2009 3. TIME REQUIREMENTS: SSI 2012 10 classes X 3hr lecture/class 30 lecture hours (includes 3 hour final exam), 60 supplemental hours Total minimum time: 90 hours [Fall Semester: 13, 2-hour sessions; 26 lecture hours] 4. CRITERIA FOR EVALUATION: A. two-hour midterm examination (50% of final grade), TBA B. two-hour final examination (50% of final grade), TBA Grades are computed according to the averages of the exams noted above and letter grades are assigned based on those averages and standards set by the Professor and the University. 5. MAKE-UP EXAMINATIONS: Make-up exams will be given only with the instructors prior approval and only with a documented, justifiable reason for his/her absence. The reason must be of a significant nature to justify absence from a scheduled exam and must be accompanied by documented proof. No make-up will be allowed for an unexcused absence from the scheduled exams.

    PHS 3505 Clinical Immunology, SSI 2012

    Dr. F.A. Barile, Ph.D., R.Ph.

    6. COURSE OUTLINE: Topic 1. Overview of the Immune System 2. Innate immunity & Acquired Immunity a. Lymphatic system b. Humoral immunity c. Cell mediated immunity d. Characteristics of the immune response e. Inflammation & cytokines 3. Immunogens & Antigens a. Chemical complexity b. Haptens c. Classes of antigens d. Cross reactivity e. Adjuvants 4. Antibody structure & function a. Characterization b. Structure c. Classes of immunoglobulins d. Genetic basis of antibody structure e. Biological properties 5. Antigen-Antibody interactions 1. Affinity and avidity 2. Agglutination reactions 3. Precipitation reactions 4. Immunoassays 5. lmmunofluorescence 6. Immunoabsorption & immunoadsorption 7. Monoclonal antibodies Midterm Exam, TBA 6. Genetic basis of antibody structure 7. Complement 8. Hypersensitivity Reactions & the Cytokines 1. Type I - AB-mediated reactions 2. Type II - AB-mediated cytotoxic reactions 3. Type III - Immune complex reactions 4. Type IV - Delayed type hypersensitivity 6 13 Chapters in text 1 2

    11 3

    14 15 15 16

    PHS 3505 Clinical Immunology, SSI 2012

    Dr. F.A. Barile, Ph.D., R.Ph.

    Topic 9. Disorders of the Immune System - Autoimmunity a. Autoimmune hemolytic anemia b. Rheumatoid Arthritis c. SLE d. Myasthenia gravis e. Graves disease f. Hashimoto's disease g. Multiple sclerosis. h. Autoimmune reactions of the kidney 10. Other disorders of the immune system 1. Immunodeficiency disorders 2. Acquired immunodeficiency syndrome 3. Gammopathies 4. B and T cell malignancies 11. Immunotherapy a. Immunization b. Production of vaccines c. Immunostimulation d. Adverse immune reactions to drugs Final Exam, Thursday June 28th, 2012

    Chapters in text 12, 17

    17

    19, 20

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