DR Jehan Hamadneh Consultant Gynecology Endocrinology and Reproductive Medicine
DR Jehan Hamadneh Consultant Gynecology Endocrinology and Reproductive Medicine
DR Jehan Hamadneh Consultant Gynecology Endocrinology and Reproductive Medicine
CONSULTANT
Gynecology endocrinology
and
Reproductive Medicine
1. Barrier Methods
Methods that physically or chemically
block sperm from reaching an egg AND
provide a BARRIER between direct skin
to skin contact.
Diaphragm
Cervical cap
Female condom
Female
Advantages
Provides some protection to the labia and
the base of the penis during intercourse.
The sheath is coated on the inside with a
silicone-based lubricant.
It does not deteriorate with oil-based
lubricants.
Disadvantages
The lubricant does not contain spermicide.
The device is difficult to place in the vagina.
The inner ring may cause discomfort. Some
users consider the female condom
cumbersome.
The female condom may cause a urinary
tract infection if left in vagina for a
prolonged period
Advantages
Does not require hormonal usage. Contraception is
controlled by the woman.
may be placed by the woman in anticipation of
intercourse.
Disadvantages
Prolonged use during multiple acts of intercourse
may increase the risk of urinary tract infections.
Usage for longer than 24 hours is not recommended
due to the possible risk of
toxic shock syndrome (TSS).
The diaphragm requires professional fitting. Poorly
fitted diaphragms may cause vaginal erosions.
Disadvantages
Cervical erosion may lead to vaginal spotting.
A theoretical risk of TSS if it is left in place longer
than the prescribed period.
Requires professional fitting and training for use.
Severe obesity may make placement difficult.
It has a relatively high failure rate.
Candidates must have history of normal results on
Papanicolaou (Pap) tests.
Advantages
The lubrication provided by spermicides may
heighten satisfaction in both partners.
the ease of application. Either partner can
purchase and apply spermicide because it is easily
accessible, available over the counter, and
inexpensive.
Applying spermicide requires minimal patient
education. It augments contraceptive efficacy of
the cervical cap and diaphragm. Spermicides
produce no adverse systemic effects.
Disadvantages
Spermicides provide minimal protection from
STDs.
Insertion may be uncomfortable for some
couples.
Vaginal irritation is possible, and spermicides
may cause an allergic reaction.
3. Hormonal Methods
Oral contraceptive - Combined oestrogen/
progestogen
- Progestogen only
Depot progestogens Injections
- Subcutaneous silicone
implants
Vaginal
- Silicone rings releasing oestrogen
& progestogen
Efficacy
The failure rate in typical use is estimated to
be approximately 25%.
Advantages
No adverse effects from hormones occur. This
may be the only method acceptable to
couples for cultural or religious reasons.
Immediate return of fertility occurs with
cessation of use.
Disadvantages
This is most suitable for women with regular
and predictable cycles.
Complete abstinence is necessary during the
fertile period unless backup contraception is
used.
This method requires discipline. The method
is not effective with improper use.
The failure rate is relatively high.
This method does not protect against STDs
5. Surgical Methods
with laparoscopy, laparotomy, or colpotomy
Laparoscopic sterilisation - Falope Rings
- Clips
- bands
segmental destruction with - Bipolar
diathermy
- Laser
Tubal ligation
suture ligation with partial salpingectomy.
6. Immunological Methods
- These are still at an investigative stage.
Condom
Vasectomy
Male oral contraception with androgens
and with cotton seed oil
Immunological contraception
Still at
investigative
.stage
Male
Advantages
Condoms are readily available and are usually
inexpensive. This method involves the male
partner in the contraceptive choice. Condoms are
effective against both pregnancy and STDs.
Disadvantages
Condoms possibly decrease enjoyment of sex.
Some users may have a latex allergy. Condom
breakage and slippage decrease effectiveness. Oilbased lubricants may damage the condom
Advantages
Include immediate availability, no devices,
no cost, no chemical involvement, and a
theoretical reduced risk of transmission of
sexually transmitted diseases (STDs).
Disadvantages
The probability ofpregnancyis high with
incorrect or inconsistent use.
Efficacy
The perfect-use failure rate within the first 6
months is 0.5%. The typical-use failure rate
within the first 6 months is 2%.
Advantages
Involution of the uterus occurs more rapidly.
Menses are suppressed. can be used
immediately after childbirth. facilitates
postpartum weight loss.
Disadvantages
Return to fertility is uncertain.
Frequent breastfeeding may be inconvenient.
Efficacy
COCP is highly effective 99.9% in preventing
pregnancy.
30% of women miss 3 or more pills in the 1st cycle
of use
47% miss 1 or more pills
body Wt may the efficacy of the pills ( not
proven)
Indication
Any women seeking a reversible, reliable, coitallyindependent method of contraception, in the
absence of contraindications
Mechanism of action
Suppression of gonadotropin secretion
inhibition of ovulation (main mechanism)
Development of endometrial atrophy making it
unreceptive to implantation
Production of viscous Cx mucous that impede
sperm transport
Possible effect on the secretions & peristalsis
of the fallopian tube interfering with ovum &
sperm transport
Relative contraindications
Non-contraceptive benefits
Cycle regulation
menstrual flow
anemia
dysmenorrhea
acne
hirsutism
ovarian ca 50%
after 5 Y of use
bone mineral
density
reduce and sometimes
eliminate
mittelschmerz.
endometrial ca 50%
risk of fibroids
Possibly ovarian cysts
Possibly benign breast
disease
Possibly colorectal ca
incidence of salpingitis
incidence or severity of
premenstrual syndrome
peri-menopausal
symptoms
Ectopic pregnancies are
prevented by the cessation
of ovulation.
Hepatocellular adenoma:
Although these tumors are histologically
benign, their danger lies in the risk of
rupture of the capsule of the liver, leading to
extensive bleeding and, possibly, death.
With the current low-dose oral contraceptive
combination, the risk for liver tumors is
much lower.
3-Wt gain
Placebo controlled trials have failed to show any
association between wt gain & COCP
4-Mood changes
Women report depression & mood changes
Placebo controlled trials have failed to show any
significantly increased risk of mood changes with
COCP
1-Venous thromboembolism
VTE 3-4 X higher in users than nonusers
Absolute risk of VTE in COCP users
1-1.5/10 000/year
Risk of VTE is higher during the 1st year of use than
subsequent years
Incidence of VTE in nonpregnant women is 0.3/
10000/year at 20-24 Y------0.6 at 40-44 Y
Incidence of VTE in pregnancy is 13/ 10000 deliveries
The risk is attributed to the estrogen component of
the pill & decline with lower dosage
2- Myocardial infarction
In the past with pills containing >50g
ethinyl estradiole --- 3X in MI
3-Stroke
Some studies showed 2X risk of stroke
Smoking & HPT risk of stroke
4-Gallbladder disease
COCP secretion of cholic acid in bile incidence
of gallstone formation
5-Breast cancer
Still controversial
A large meta-analysis 1996 significant risk of
breast ca in women currently taking the COCP & in
the 1st 10 Y after discontinuing it
5-Breast cancer
Cumulative breast ca risk up to age 35 is 2 / 1000
with COCP --------------------------------------- 3 / 1000
It is not known whether this is due to the pills or due
to delaying the 1st full term birth
More recent study > 9000 women no significant
in breast ca risk
No risk with different dosage of estrogen, longer
periods of use, or with different progestin components
No risk in Pt with family Hx of breast ca
No risk in Pt who started using the pills at an
earlier age
risk in Pt who carry BRCA1, BRCA2 genes
6-Cervical cancer
One study risk of Cx ca in long term COCP
users who are HPV positive
A review of 28 studies of women with Cx ca risk
of Cx ca with duration of COCP use
Probably due to risk of HPV (a major risk factor
for cx ca) that might be related to sexual behavior
which differs in users & non users of COCP
Another study HPV + ve women follwed up for 10
years showed no increased risk
Patient assessment
A thorough Hx to exclude contraindications,
smoking & medications
BP
Pelvic exam not mandatory before prescribing
COCP
No routine lab screening is required
Counselling
Instructions on how to use the pills
To start in the 1st 5 days of the cycle
Quick start method any day of the cycle
requires the use of back up method of
contraception for the 1st wk
1-Breakthrough bleeding
To continue on the same pills with the
expectation that it will improve with time
(rather than switching to another preparation)
If bleeding persists beyond 3 M (or new onset of
bleeding in a long term user ) rule out other
causes of bleeding:
-irregular taking of the pills
-pregnancy
-infections
-uterine or Cx pathology
-malabsorption/ diarrhea , vomitting
-concomitant use of medications
2-Missed pills
<12 hrs Take the pill as soon as you remember ( this means taking 2 in 1
day)
>12 hrs .use another method for 1 week
If 2 pills in a row missed in the 1 st 2 wks of the pack take 2 /day for 2
days
If 2 pills in a row missed in the 3 rd wk of the pack through the remainder
of the pack & start a new one / use back up contraception in the first 7
days of the new pack
If 3 pills in a row missed follow steps above
3-Amenorrhea
It occurs in 2-3% of COCP users
Pregnancy should be ruled out
It is not dangerous no need for Rx
If not acceptable by Pt change preparation
Add oral estrogen for 10 days
4-Chloasma
Darkening of the facial skin
Changing to another preparation will not help
It may never completely disappear
Use of sunscreen to prevent further darkening
Advantages
NuvaRing is highly effective because it results in
complete suppression of ovulation. The steady
release of hormone provides exceptional cycle
control. The ring is a very effective reversible
method of birth control.
The ring delivers the lowest dose of ethinyl
estradiol compared with other combined hormonal
contraceptives. Unlike combined oral
contraceptives, the adverse effects of nausea and
vomiting are avoided with ring use
Disadvantages
Adverse effects include headaches and
vaginal irritation or discharge.
The ring may accidentally slip out during
intercourse and either the user or the
partner may feel the ring during sexual
intercourse.
Contraindications are similar to those of
combined oral contraceptiv
It
Ring
Wt gain 4 pounds/year
Mechanism of action
Inhibiting the secretion of pituitary gonadotropins
suppression of ovulation *1ry mechanism*
viscosity of Cx mucous
Induces endometrial atrophy
Absolute contraindications
Pregnancy
Unexplained vaginal bleeding
Current breast ca
Relative contraindications
Severe liver cirrhosis
Active viral hepatitis
Benign hepatic adenoma
Advantages
DMPA does not produce the serious adverse
effects of estrogen, such as
thromboembolism.
The risks of endometrial and ovarian cancer
are decreased.
It contains no estrogen, thus making it
suitable for women who cannot or will not
take estrogen products.
It also is safe for breastfeeding mothers
3-Weight gain
56% Wt ( mean gain 4.1 kg) possibly through
appetite stimulation & a mild anabolic effect
- 2.5 kg in 1st Y
-3.7 kg in 2 Y
-6.3 kg in 4 Y
44% Wt or maintained (mean loss 1.7 kg)
4-Mood effects
Prospective studies did not demonstrate
depressive symptoms
Some women discontinue use because of mood
changes
2-Late injection
<14 wks since last injection it can be given
14 wks since last injection
-ve serum hcg, no intercourse for last 10 days
give the injection
back up contraception must be used for 2 wks
14 wks since last injection
-ve serum hcg,intercourse within the last 10 D
give the injection
back up contraception must be used for 2 wks
Repeat serum hcg 2 wks
Not teratogenic if inadvertently given during
pregnancy
Indications
It can be used for any women seeking
reliable, reversible, coitally independent
method of contraception in the absence of
contraindications
Women with contraindication to estrogen
Women > 35 Y who smoke
Women having migraine headache with
neurological symptoms
Women who have unwanted side-effects of
COCP
Breast-feeding women
Mechanism of action
1-Main mechanism is alteration of Cx mucous
volume of mucous
viscosity
alter its molecular structure
Little or no sperm penetration
Sperm motility is impaired fertilization
2- Ovulation is suppressed in 60% of the women.
suppression of ovulation (not uniformly in all cycles.
a reduction in cilia motility in the fallopian tube, thus
slowing the rate of ovum transport
3-Endometrial changes implantation
Absolute Contraindications
Pregnancy
Current breast cancer
Relative Contraindications
Active viral hepatitis
Liver tumors
Risks
Not associated with any major morbidity
No risk of VTE, stroke or MI
Myths & misconception
It can only be used with breast feeding
Fact It can be used in any women seeking
reliable, reversible method of contraception
POP is not an effective method of contraception
Fact When used correctly it is safe & effective
with a failure rate of only 0.5%
1-Irregular bleeding
A common side effect
Pregnancy, infection & genital pathology must be
ruled out
Rx options
Non steroidal anti-inflammatory for 10 days
Switching toCOCP
Adding a short course of estrogen
0.625 mg conjugated equine estrogen
(premarine) for 28 days
1-2 mg micronized 17-estradiole28 days
Transdermal 50-100 g 17-estradiole patch 25
days
Antiprogestinic agents mifepristone
2-Missed pill
To be taken as soon as possible
Next pill to be taken at the regular time
If delayed > 3hrs use back up
contraception for 48 hrs
If 2 or more pills missed in a row 2
pills/day for 2 days back up contraception
for 48 hrs
Emergency contraception must be used if
intercourse occurred after a missed pill
3- Drug interactions anticonvulsants may
effectiveness of POP
NORPLANT Levonorgestril
Implanon Etonogestrel
Highly effective failure rate 0.1% / year
NORPLANT 6 rods implanted under the skin
effective for 5 years
Implanon One rod effective for 3 years
Reversible contraception
Mechanism of action
Suppression of ovulation
Endometrial atrophy
Rendering Cx mucous impermeable to sperms
Prolonged irregular bleeding the major side
effect
Advantages
The longevity of its effectiveness.
Its effectiveness is not related to its use in regards
to coitus.
Exogenous estrogen is absent.
Prompt return to the previous state of fertility
occurs upon removal.
No adverse effect on breast milk production occurs.
Disadvantages
A minor surgical procedure is necessary for
insertion.
Difficulty in removal.
Menstrual irregularities are common along with
other adverse effects, including headaches, mood
changes, hirsutism, galactorrhea, and acne.
Appropriate candidates are women who are
postpartum or breastfeeding, women who have
difficulty with contraceptive compliance, women
in whom pregnancy is contraindicated due to a
medical condition, and patients with
contraindications to the use of estrogen.
Advantages
IUDs produce no adverse systemic effects.
Ectopic pregnancies are reduced overall;
however, the ratio of extrauterine to
intrauterine pregnancy is increased if
conception does occur.
Menstrual blood loss and dysmenorrhea are
decreased with Progestasert.
Twenty percent of women experience
amenorrhea with Mirena.
Disadvantages
Risk of uterine perforation at the time of insertion.
Increased dysmenorrhea occurs with the Copper T380.
Increased menstrual blood loss occurs in the first few
cycles with use of the Copper T380 and Mirena IUDs.
Whether IUDs increase the risk of PID is controversial.
IUDs may be expelled unnoticed, and they do not
protect against STDs.
Absolute contraindications
Pregnancy
Current, recurrent or recent (within 3 M) PID or
sexually transmitted disease
Puerperal sepsis
Immediate post septic abortion
Severely distorted uterine cavity
Unexplained vaginal bleeding
Cx or endometrial ca
Malignant trophoblastic disease
Copper allergy/Wilson disease, Copper -IUCD
Breast ca LNG -IUCD
Relative contraindications
Risk factor for sexually transmitted diseases or HIV
Increased susceptibility to infection (eg, those with
leukemia, diabetes, valvular heart disease, or AIDS,women on corticosteroid Rx
48hrs- 4 wks postpartum
Ovarian ca
Benign gestational trophoblastic disease
History of ectopic pregnancy,
1-Bleeding
Copper / non medicated IUCD
Irregular menstrual bleeding
amount of menstrual bleeding 65% in copper
IUCD users
NSAID or tranexamic acid menstrual blood
loss
The days of bleeding or spotting overtime 13
days in the 1st months 6 days at 1 year
Discontinuation due to bleeding 20%
LNG-IUCD
menstrualblood loss 74-97%
Spotting 16 days at 1 M 4 days at 12 M
Discontinuation due to bleeding 14%
Amenorrhea 16-35% at 12 M
2-Pain or dysmenorrhea
6% discontinue use due to pain
Pain may be physiological
LNG-IUCD dysmenorrhea
3-Hormonal LNG-IUCD
Depression
Acne
Headache
Breast tenderness
Low incidence ,maximal at 3 M then
No change in Wt
1-Uterine perforation
A rare complication at insertion
0.6-1.6/1000 insertion
Risk factors
Postpartum insertion
Inexperienced operator
Immobile uterus
Extremely ante or retro verted uterus
2-Expulsion
2-10% in the 1st year of use
Risk factors: postpartum insertion,
nulliparity,previous expulsion(30% chance)
3-Infection
Risk is only in the 1st few months after insertion
Inverse relation between infection & time since
insertion
4-Failure
If a woman become pregnant with an IUCD
exclude ectopic
Abortion is in women pregnant with IUCD in
place
Copper IUCD abortion 75% if left in situ
Live birth 89% if IUCD removed
Preterm delivery in women pregnant with IUCD
in place
Counselling
Inserted any time during a menstrual cycle once
pregnancy excluded
During menses exclude pregnancy & mask
insertion related bleeding
Infection & expulsion with insertion during menses
It can be removed any day of the menstrual cycle
If there is mucpurulent discharge Cx swabs must
be taken & insertion delayed
Antibiotic prophylaxis is not indicated
1-Lost string
Speculum exam
Exclude pregnancy
Cx canal explored
U/S
Plain X ray
2- Pregnancy
Exclude ectopic
If she wishes to continue the pregnancy
remove IUCD
If string missing u/s if in the uterus no
attempt to remove it
Disadvantages
Adverse effects include nausea and emesis, minor
changes in menses, breast tenderness, fatigue,
headache, abdominal pain, and dizziness. Ectopic
pregnancy is possible if treatment fails.
Effectiveness
Yuzpe 75% reduction in pregnancy
pregnancy rate 3.2%
LNG 89% reduction
pregnancy rate 1.1%
Effectiveness with delay between
intercourse & contraception
IUCD more effective 98.7%
Side effects
LNG have lower incidence of nausea(23 vs 50%),
vomitting (5.6vs 18.8%), dizziness (11.2vs16.7%),
fatigue (16.9vs28.8%)than Yuzpe
Vasectomy:
This operation is done to keep a mans sperm
from going to his penis, so his ejaculate never
has any sperm in it that can fertilize an egg.
Operation is more simple than tying a
womans tubes
Vasectomy involves incision of the scrotal sac,
transection of the vas deferens, and occlusion
of both severed ends by suture ligation or
fulguration.
Efficacy
The failure rate is approximately 0.1%.
Advantages
Vasectomy involves no hormones, is permanent, is
an outpatient procedure, is quick, and carries
minimal risk with regard to the procedure.
Disadvantages
Patients may regret their decision after the
procedure. Alternative contraception is required
until the ejaculate is deemed free of sperm.
Vasectomy does not prevent STDs. Short-term
discomfort occurs
A) Male Condom
B) Birth Control Pill
C) Abstinence
Answer:
C) Abstinence
A) Male Condom
ONLY, because
B) Birth Control Pill does NOT protect against
STDs, only pregnancy!
True
FALSE:
True or False:
Correct Answer:
CORRECT ANSWER
D) 5-10 years
Correct Answer:
B) 3