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    Predisposing Factor of Fungal Infection

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    Ditha Rizky
    This document discusses predisposing factors for fungal infections. Local factors include conditions that reduce saliva secretion like Sjogren's syndrome, radiotherapy, and certain drugs as saliva helps prevent fungal overgrowth. Poor oral hygiene and ill-fitting dentures also increase risk by creating environments suitable for fungal growth. Systemic factors include immunodeficiencies, long-term broad spectrum antibiotic or immunosuppressive drug use, smoking, diabetes, and other conditions that impair immunity.

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    Predisposing Factor of Fungal Infection

    Uploaded by

    Ditha Rizky
    223 views13 pages
    This document discusses predisposing factors for fungal infections. Local factors include conditions that reduce saliva secretion like Sjogren's syndrome, radiotherapy, and certain drugs as saliva helps prevent fungal overgrowth. Poor oral hygiene and ill-fitting dentures also increase risk by creating environments suitable for fungal growth. Systemic factors include immunodeficiencies, long-term broad spectrum antibiotic or immunosuppressive drug use, smoking, diabetes, and other conditions that impair immunity.

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    This document discusses predisposing factors for fungal infections. Local factors include conditions that reduce saliva secretion like Sjogren's syndrome, radiotherapy, and certain drugs as saliva helps prevent fungal overgrowth. Poor oral hygiene and ill-fitting dentures also increase risk by creating environments suitable for fungal growth. Systemic factors include immunodeficiencies, long-term broad spectrum antibiotic or immunosuppressive drug use, smoking, diabetes, and other conditions that impair immunity.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    223 views13 pages

    Predisposing Factor of Fungal Infection

    Uploaded by

    Ditha Rizky
    This document discusses predisposing factors for fungal infections. Local factors include conditions that reduce saliva secretion like Sjogren's syndrome, radiotherapy, and certain drugs as saliva helps prevent fungal overgrowth. Poor oral hygiene and ill-fitting dentures also increase risk by creating environments suitable for fungal growth. Systemic factors include immunodeficiencies, long-term broad spectrum antibiotic or immunosuppressive drug use, smoking, diabetes, and other conditions that impair immunity.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 13

    Predisposing Factor Of

    Fungal Infection

    Local factor

    Local factors
    A. Xerostomia
    B. Obat
    C. Denture
    D. Faktor lain

    xerostomia
    salivary gland function can predispose to oral
    candidiasis.
    Secretion of saliva causes a dilutional effect and
    removes organisms from the mucosa.
    Antimicrobial proteins in the saliva such as lactoferrin,
    sialoperoxidase, lysozyme,
    histidine-rich polypeptides,and specific anticandida
    antibodies,interact with the oral mucosa and prevent overgrowth of
    candida.
    Therefore conditions such as Sjgrens syndrome,
    radiotherapy of the head and neck,or drugs that reduce salivary
    secretions can lead to an increased risk of oral candidiasis.

    Pemakaian obat
    berkepanjangan
    Drugs such as inhaled steroids, have
    been shown to increase the risk of
    oral candidiasis by possibly
    suppressing cellular immunity and
    phagocytosis.

    OH buruk dan Denture


    Oral hygiene involves cleaning the teeth, buccal cavity,
    tongue, and dentures
    Dentures should be
    cleaned and disinfected daily and left out overnight or for at
    least six hours daily.
    The dentures should be soaked in a denture cleaning
    solution such as chlorhexidine as this is more effective in
    eliminating candida than brushing. This is because dentures
    have irregular and porous surfaces to which candida easily
    adheres and brushing alone cannot remove them

    Wearing of dentures produces a


    microenvironment conducive to the
    growth of candida with low oxygen, low
    pH, and an anaerobic environment. This
    may be due to enhanced adherence of
    Candida spp to acrylic, reduced saliva
    flow under the surfaces of the denture
    fittings, improperly fitted dentures, or
    poor oral hygiene.

    Other factor
    Other factors are a high
    carbohydrate diet. Growth of candida
    in saliva is enhanced by the
    presence of glucose and its
    adherence to oral epithelial cells is
    enhanced by a high carbohydrate
    diet.

    Systemic factors
    A. Immunodefisiensi
    B. Obat
    C. Other factor systemic

    immunodefisiensi
    Extremes of life predispose to
    infection because of
    reducedimmunity.

    Pemakaian obat
    berkepanjangan
    Drugs such as broad spectrum antibiotics alter
    the local oralflora creating a suitable
    environment for candida to
    proliferate.
    Immunosuppressive drugs such as the
    antineoplastic agents have been shown to
    predispose to oral candidiasis by altering
    (mengubah) the oral flora,
    disrupting the mucosal surface and altering the
    character of the saliva.

    Other factor systemic


    Other factors are
    1. smoking,
    2. diabetes,
    3. Cushings syndrome,
    4. immunosuppressive conditions such as HIV infection,
    5. malignancies such as leukaemia,
    Ninane found that 15%60% of people with
    malignancies will develop oral candidiasis while they
    are immunosuppressed.
    6. nutritional deficiencies
    vitamin B deficiencies have been particularly
    implicated.

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