Scribd Logo
Upload

Welcome to Scribd!

  • 274 views

    Principles of Topical Treatments in Dermatology

    Uploaded by

    Anonymous OlS0WZw
    This document discusses principles of topical treatments in dermatology. It covers how topical medications are absorbed through the skin, parameters to consider for cutaneous drug administration like age and skin type, common dermatologic vehicles like ointments and creams, when topical treatments are used, how to choose the right vehicle based on skin type and lesion, examples of topical agents, classes of topical corticosteroids, and potential side effects. It also provides examples of treatments that would be prescribed for different skin conditions.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd

    Principles of Topical Treatments in Dermatology

    Uploaded by

    Anonymous OlS0WZw
    274 views18 pages
    This document discusses principles of topical treatments in dermatology. It covers how topical medications are absorbed through the skin, parameters to consider for cutaneous drug administration like age and skin type, common dermatologic vehicles like ointments and creams, when topical treatments are used, how to choose the right vehicle based on skin type and lesion, examples of topical agents, classes of topical corticosteroids, and potential side effects. It also provides examples of treatments that would be prescribed for different skin conditions.

    Original Description:

    dermatoterapi

    Copyright

    © © All Rights Reserved

    Available Formats

    PPT, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document discusses principles of topical treatments in dermatology. It covers how topical medications are absorbed through the skin, parameters to consider for cutaneous drug administration like age and skin type, common dermatologic vehicles like ointments and creams, when topical treatments are used, how to choose the right vehicle based on skin type and lesion, examples of topical agents, classes of topical corticosteroids, and potential side effects. It also provides examples of treatments that would be prescribed for different skin conditions.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    274 views18 pages

    Principles of Topical Treatments in Dermatology

    Uploaded by

    Anonymous OlS0WZw
    This document discusses principles of topical treatments in dermatology. It covers how topical medications are absorbed through the skin, parameters to consider for cutaneous drug administration like age and skin type, common dermatologic vehicles like ointments and creams, when topical treatments are used, how to choose the right vehicle based on skin type and lesion, examples of topical agents, classes of topical corticosteroids, and potential side effects. It also provides examples of treatments that would be prescribed for different skin conditions.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    You are on page 1of 18

    Principles of Topical

    Treatments in
    Dermatology
    Do. Dr.Burhan Engin

    The skin has a surface area of 1.6-2 m2


    This area enables the enhancement of
    systemic treatment measures
    An extensive region for the application
    and absorption of topical medications
    The active ingredients penetrate the
    skin either via transepidermal or
    transfollicular pathways

    What are the parameters that


    should be considered for
    cutaneous drug administration

    Age of patient
    Area of the body
    Pathologic changes in the skin
    Hydration of stratum corneum and
    skin temperature
    Vascular supply
    Role of vehicle

    What are dermatologic


    vehicles?

    Powder
    Paste
    Shake lotion
    Ointment
    Hydrophilic ointment, cream or lotion
    Water

    When do we use topical


    treatment?
    If a patient has a skin disorder
    covering < 30% of body, the
    topical medication may be
    considered.

    Choice of vehicles
    Three main determinants to choose
    the right vehicle are:
    Patients skin type
    Degree of acuity of the
    disease
    Nature of the lesions

    Choice of vehicles
    Skin type: About 50% of individuals
    have oily skin or seborrhea. They do
    better with creams, lotions, or shake
    lotions while the ones with dry skin
    do better with ointments or pastes.
    Degree of acuity: Acute inflammatory
    processes are best treted with
    creams or lotions. If the lesions are
    weeping, shake lotions are fine.

    Choice of vehicles for different


    lesions
    Lesion
    Recommended
    Avoided
    Acute erythema shake lotion,
    lotion, cream
    Vesicles
    shake lotion,
    gel, lotion
    Blisters
    Wet dressings,
    shake lotions
    Erosions

    Wet dressings,
    ointment

    lotion
    Crusts
    Ointment, wet dr.
    Ch. inflammation Ointment

    Ointment,
    paste
    Paste,
    ointment
    Paste,
    ointment,
    powder
    powder,
    shake
    Powder, gel

    Topical agents
    Keratolytic agents
    Cytotatic agents: Podophyllin, 5fluorouracil
    Retinoids
    Antibiotics, antifungals, antiviral agents
    Corticosteroids
    Combination products
    Tacrolimus, pimecrolimus
    Nonsteroidal antiinflammatory agents
    Sunscreens

    Topical corticosteroids
    Class I (weakest): Hydrocortisone,
    prednisolone
    Class II: Methylprednisolone
    aceponate, triamcinolone
    Class III: Betamethasone 17-valerate
    Class IV (strongest): Clobetasol 17propionate

    Side effects of topical


    corticosteroids

    Epidermis : Atrophy
    Hair follicles: Steroid acne
    Dermis: Atrophy, striae
    Pigmentation: Hypopigmentation
    Vessels: Erythema, telangiectases

    What would you prescribe


    for:
    An infant having flares of erythema
    and small papules on the cheeks
    An infant having severe erythema
    and mild scaling involving the
    convexities of the buttocks
    A female adult having mild erythema,
    scales and fissures on the fingertips
    and volar aspect of her hands

    What would you prescribe


    for:
    A burn (with hot water) involving the
    wrist, with erythema and blisters
    A clinical picture with vesicles, yellow
    ccrusts and oozing erosions
    Hyperkeratotic plaque with scales,
    prominent skin markings and severe
    pruritus

    You might also like