Scribd Logo
Upload

Welcome to Scribd!

  • 699 views

    Chronopharmacology of Antyhipertension

    Uploaded by

    ENDANG
    The document discusses chronopharmacology and circadian rhythms related to hypertension. It defines chronobiology as the study of time's effects on living systems and biological rhythms. Chronopharmacology studies variations in drug actions over time. The mammalian circadian pacemaker resides in the suprachiasmatic nuclei (SCN) of the hypothalamus. The SCN controls circadian rhythms in response to hormonal variations. Many biological functions like temperature, hormone secretion and sleep/wake cycles follow circadian rhythms of approximately 24 hours. Hormone levels vary throughout the day, influencing conditions like hypertension that have demonstrated circadian patterns.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd

    Chronopharmacology of Antyhipertension

    Uploaded by

    ENDANG
    699 views32 pages
    The document discusses chronopharmacology and circadian rhythms related to hypertension. It defines chronobiology as the study of time's effects on living systems and biological rhythms. Chronopharmacology studies variations in drug actions over time. The mammalian circadian pacemaker resides in the suprachiasmatic nuclei (SCN) of the hypothalamus. The SCN controls circadian rhythms in response to hormonal variations. Many biological functions like temperature, hormone secretion and sleep/wake cycles follow circadian rhythms of approximately 24 hours. Hormone levels vary throughout the day, influencing conditions like hypertension that have demonstrated circadian patterns.

    Original Description:

    kronofarmakologi

    Copyright

    © © All Rights Reserved

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document discusses chronopharmacology and circadian rhythms related to hypertension. It defines chronobiology as the study of time's effects on living systems and biological rhythms. Chronopharmacology studies variations in drug actions over time. The mammalian circadian pacemaker resides in the suprachiasmatic nuclei (SCN) of the hypothalamus. The SCN controls circadian rhythms in response to hormonal variations. Many biological functions like temperature, hormone secretion and sleep/wake cycles follow circadian rhythms of approximately 24 hours. Hormone levels vary throughout the day, influencing conditions like hypertension that have demonstrated circadian patterns.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    699 views32 pages

    Chronopharmacology of Antyhipertension

    Uploaded by

    ENDANG
    The document discusses chronopharmacology and circadian rhythms related to hypertension. It defines chronobiology as the study of time's effects on living systems and biological rhythms. Chronopharmacology studies variations in drug actions over time. The mammalian circadian pacemaker resides in the suprachiasmatic nuclei (SCN) of the hypothalamus. The SCN controls circadian rhythms in response to hormonal variations. Many biological functions like temperature, hormone secretion and sleep/wake cycles follow circadian rhythms of approximately 24 hours. Hormone levels vary throughout the day, influencing conditions like hypertension that have demonstrated circadian patterns.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 32
    At a glance
    Powered by AI
    The key takeaways are that biological rhythms are influenced by circadian rhythms which are regulated by the biological clock located in the suprachiasmatic nuclei. Examples of circadian rhythms include hormone secretion, body temperature, sleep-wake cycles.

    The biological clock is located in the suprachiasmatic nuclei of the hypothalamus. It coordinates the timing of physiological functions and behaviors to the natural day-night cycle in response to light signals received from the eyes.

    Circadian rhythms are biological events or functions that occur in cycles of approximately 24 hours. Examples include body temperature, hormone secretion, metabolism, and sleep-wake cycles. Specific hormones and biological functions peak at different times of the day.

    CHRONOPHARMACOLOGY OF

    HYPERTENSION

    Kelompok III

    12/7/16
    INTRODUCTION

    Chronobiology is the scientific study of effect of time on


    living systems and biological rhythms.
    Chronopharmacology is the science concerned with the
    variations in the pharmacological actions of various drugs
    over a period of time of the day.
    A biological rhythm is one or more biological events or
    functions that reoccur in time in a repeated order and with
    a repeated interval between occurrences .
    The biological clock is the mechanism found within living
    organisms that coordinates the timing of physiological
    functions and behaviors to the natural day-night cycle.
    2

    12/7/16

    The mammalian Circadian pacemaker resides in the


    paired suprachiasmatic nuclei (SCN).
    When light falls on the eye, afferent nerves arising from
    the retina of the eye transmit the light signals directly
    through retino hypothalamic tract to the paired
    suprachiasmatic nuclei situated in the hypothalamus and
    pineal gland.
    Biological clock since found is represented by
    suprachiasmatic nuclei , which creates biological rhythms
    under control of clock genes.
    3

    12/7/16

    Circadian rhythm:
    Derived from the Latin circa, meaning "around," and dies,
    meaning "day. Circadian : around a day.
    Rhythm is the measured movement, recurrence of action
    or function at regular intervals.
    Circadian rhythm is the regular recurrence of certain
    phenomena in cycles of approximately 24 hours.
    The best-known circadian rhythms include
    body
    temperature , hormone secretion, metabolism, sleep or
    wake cycle .
    4

    12/7/16

    The suprachiasmatic nucleus controls circadian


    rhythms in response to hormonal variation in
    the body

    12/7/16

    Types of biological rhythms:

    12/7/16
    BIOLOGICAL CLOCK
    IN HUMAN

    12/7/16

    10

    12/7/16

    The hormones that are secreted in the morning include


    cortisol, catecholamines, plasma renin, aldosterone, and
    angiotensin.
    In contrast, gastric acid, growth hormone, prolactin,
    melatonin,
    follicle-stimulating
    hormone,
    luteinizing
    hormone, and adreno-corticotrophic hormone (ACTH)
    peak in the evening or during sleep.
    For instance, the increase in catecholamines in the
    morning promotes platelet aggregation. This is especially
    important since fibrinogen also increases, and the bodys
    own endogenous t-PA decreases, promoting a
    procoagulant state with increased blood viscosity.
    Cholesterol synthesis is more in the evening than in the
    morning.
    11

    12/7/16

    Circadian Rhythms in Occurrence and


    Severity of Disease
    Sudden infant death, symptoms of allergic rhinitis, and
    rheumatoid arthritis are either most intense overnight or in the
    morning upon wakening.
    Migraine headache is typically triggered during rapid eyeball
    movement (REM) episodes during night time sleep or in the
    early morning hours after awakening.
    Angina pectoris, ventricular arrhythmia, acute myocardial
    infarction, sudden cardiac death, stroke, fatal pulmonary
    embolism, and hypertensive crises, all are most frequent in
    the morning.
    12

    CIRCARDIAN RHYTM

    THE CIRCARDIAN CLOCK IN


    MAMALS

    CHRONOPHARMACOLOGY
    OF HYPERTENSION

    BLOOD PRESSURE RHYTHM

    MORNING HYPERTENSION

    THANK YOU

    You might also like