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    The document discusses the role of thermodynamics in microbial growth. It explains that microbial growth is an irreversible and spontaneous process where entropy is produced despite biomass being structured. It presents equations for entropy balance and Gibbs energy balance for a growing microbial cell. The document also relates the driving force for growth to biomass yield, and shows experimental results investigating this relationship for different growth processes like aerobic growth on glucose and ethanol fermentation. It provides equations to predict biomass yield based on calculating Gibbs energies of catabolic and anabolic reactions. The document additionally discusses parameters like Gibbs energy dissipation rate due to maintenance mechanisms.

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    The document discusses the role of thermodynamics in microbial growth. It explains that microbial growth is an irreversible and spontaneous process where entropy is produced despite biomass being structured. It presents equations for entropy balance and Gibbs energy balance for a growing microbial cell. The document also relates the driving force for growth to biomass yield, and shows experimental results investigating this relationship for different growth processes like aerobic growth on glucose and ethanol fermentation. It provides equations to predict biomass yield based on calculating Gibbs energies of catabolic and anabolic reactions. The document additionally discusses parameters like Gibbs energy dissipation rate due to maintenance mechanisms.

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    Introduction about thermodynamics on microbial growth.

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    The document discusses the role of thermodynamics in microbial growth. It explains that microbial growth is an irreversible and spontaneous process where entropy is produced despite biomass being structured. It presents equations for entropy balance and Gibbs energy balance for a growing microbial cell. The document also relates the driving force for growth to biomass yield, and shows experimental results investigating this relationship for different growth processes like aerobic growth on glucose and ethanol fermentation. It provides equations to predict biomass yield based on calculating Gibbs energies of catabolic and anabolic reactions. The document additionally discusses parameters like Gibbs energy dissipation rate due to maintenance mechanisms.

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    © All Rights Reserved
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    Download as pptx, pdf, or txt
    47 views11 pages

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    Uploaded by

    saipa1
    The document discusses the role of thermodynamics in microbial growth. It explains that microbial growth is an irreversible and spontaneous process where entropy is produced despite biomass being structured. It presents equations for entropy balance and Gibbs energy balance for a growing microbial cell. The document also relates the driving force for growth to biomass yield, and shows experimental results investigating this relationship for different growth processes like aerobic growth on glucose and ethanol fermentation. It provides equations to predict biomass yield based on calculating Gibbs energies of catabolic and anabolic reactions. The document additionally discusses parameters like Gibbs energy dissipation rate due to maintenance mechanisms.

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    You are on page 1of 11

    Role of Thermodynamics in

    microbial growth
    - Sai Pavan
    Driving Force for Microbial Growth

    • Microbial growth is irreversible & spontaneous process


    • Entropy is produced
    • Biomass is structured therefore entropy should be decreased
    • Entropy balance equation for microbial cell

    Fig1: Entropy balance for growing cell


    Driving Force for Microbial Growth

    • Enthalpy balance for microbial growing cell

    • Gibbs energy balance

    • Molar balance over the cells

    • Solving Gibbs energy and molar balance equation at steady


    state leads to
    Relationship between driving force for growth &
    biomass yield

    • Macrochemical reaction is split into catabolic part and


    anabolic part

    Fig 2: Gibbs energy for catabolic and anabolic reactions

    • Relationship is given as
    Experimental Results

    • The relationship between the driving force for growth and the
    biomass yield was investigated for several different growth
    processes

    Fig3: Aerobic growth on Fig4: Ethanol fermentation


    glucose
    Experimental Results

    Fig6: Acetotrophic methanogenesis

    Fig5: Lactic Acid fermentation

    Fig7: Contribution of driving forces


    Prediction of Biomass Yield

    • Biomass yield is predicted as

    • Calculation of Gibbs energies of both catabolic and


    anabolic is done as
    Other growth parameters

    • Gibbs energy dissipation rate due to maintenance


    mechanisms

    • Where
    Calorimetric Investigations
    • What system needs to be investigated?
    Thank You

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