Scribd Logo
Upload

Welcome to Scribd!

  • 62 views

    Lewis System & The Biological Significance: Prepared by

    Uploaded by

    Chelly Jimeno
    This document discusses the Lewis blood group system and its biological significance. It explains that Lewis antigens are synthesized by tissue cells and secreted into body fluids rather than being synthesized directly by red blood cells. It also describes that Lewis antibodies are generally IgM and can bind complement. Finally, it provides information on Lewis genes and the frequencies of different Lewis phenotypes in different populations.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd

    Lewis System & The Biological Significance: Prepared by

    Uploaded by

    Chelly Jimeno
    62 views5 pages
    This document discusses the Lewis blood group system and its biological significance. It explains that Lewis antigens are synthesized by tissue cells and secreted into body fluids rather than being synthesized directly by red blood cells. It also describes that Lewis antibodies are generally IgM and can bind complement. Finally, it provides information on Lewis genes and the frequencies of different Lewis phenotypes in different populations.

    Original Description:

    bb

    Original Title

    Lewis

    Copyright

    © © All Rights Reserved

    Available Formats

    PPT, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document discusses the Lewis blood group system and its biological significance. It explains that Lewis antigens are synthesized by tissue cells and secreted into body fluids rather than being synthesized directly by red blood cells. It also describes that Lewis antibodies are generally IgM and can bind complement. Finally, it provides information on Lewis genes and the frequencies of different Lewis phenotypes in different populations.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    62 views5 pages

    Lewis System & The Biological Significance: Prepared by

    Uploaded by

    Chelly Jimeno
    This document discusses the Lewis blood group system and its biological significance. It explains that Lewis antigens are synthesized by tissue cells and secreted into body fluids rather than being synthesized directly by red blood cells. It also describes that Lewis antibodies are generally IgM and can bind complement. Finally, it provides information on Lewis genes and the frequencies of different Lewis phenotypes in different populations.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    You are on page 1of 5

    LEWIS SYSTEM & THE BIOLOGICAL

    SIGNIFICANCE

    PREPARED BY:
    CARRIZA DARCY G. CALO, RMT,
    IMT(ASCPi)
    Lewis Antigens

     Not synthesized by RBCs


     Synthesized by tissue cells, secreted into
    body fluids & plasma, & adsorbed onto the
    RBC membrane
     Secretions = glyCHONs
    RBC = glycolipids
     Poorly expressed at birth
     Do not demostrate dosage in serologic
    reactions
    Lewis Antibodies

     Generally IgM
     Capable of binding complement
     Enhanced by enzymes
     Neutralize Lewis substance in
    secretions
     Encountered in pregnant women
     Not significant in transfusion medicine
    Lewis Genes

     Le gene codes for L-fucolsyltransferase


     Le gene is needed for expression of Lea
    substance; Le & Se genes are needed to
    form Leb substance
     Le(a+b-) = ABH nonsecretors; have only Lea
    substance in secretions
     Le(a-b+) = ABH secretors; have both Lea &
    Leb substances in secretions
    Frequency

     Le(a-b+)
    – Common phenotype in both whites &
    blacks
     lele genotype/Le(a-b-) phenotype
    – Common among blacks

    You might also like