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    9 Th. Lec. Lewis Blood Group System

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    da202263357026
    The Lewis blood group system involves Lewis antigens that are not synthesized by red blood cells, but are incorporated into their membranes. Lewis antigens are manufactured by tissue cells and secreted into body fluids, then adsorbed onto red cell membranes. The Lewis gene codes for an enzyme that adds fucose sugar to precursor substances on red blood cells. A person's Lewis antigen status depends on inheritance of the Lewis, Secretor, and H genes. Individuals can inherit genes allowing Lewis antigen secretion even if they do not secrete ABH antigens. The substances secreted and antigens present on red cells are determined by complex interactions between these inherited genes.

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    9 Th. Lec. Lewis Blood Group System

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    da202263357026
    81 views11 pages
    The Lewis blood group system involves Lewis antigens that are not synthesized by red blood cells, but are incorporated into their membranes. Lewis antigens are manufactured by tissue cells and secreted into body fluids, then adsorbed onto red cell membranes. The Lewis gene codes for an enzyme that adds fucose sugar to precursor substances on red blood cells. A person's Lewis antigen status depends on inheritance of the Lewis, Secretor, and H genes. Individuals can inherit genes allowing Lewis antigen secretion even if they do not secrete ABH antigens. The substances secreted and antigens present on red cells are determined by complex interactions between these inherited genes.

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    9 th. lec. Lewis blood group system

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    The Lewis blood group system involves Lewis antigens that are not synthesized by red blood cells, but are incorporated into their membranes. Lewis antigens are manufactured by tissue cells and secreted into body fluids, then adsorbed onto red cell membranes. The Lewis gene codes for an enzyme that adds fucose sugar to precursor substances on red blood cells. A person's Lewis antigen status depends on inheritance of the Lewis, Secretor, and H genes. Individuals can inherit genes allowing Lewis antigen secretion even if they do not secrete ABH antigens. The substances secreted and antigens present on red cells are determined by complex interactions between these inherited genes.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    81 views11 pages

    9 Th. Lec. Lewis Blood Group System

    Uploaded by

    da202263357026
    The Lewis blood group system involves Lewis antigens that are not synthesized by red blood cells, but are incorporated into their membranes. Lewis antigens are manufactured by tissue cells and secreted into body fluids, then adsorbed onto red cell membranes. The Lewis gene codes for an enzyme that adds fucose sugar to precursor substances on red blood cells. A person's Lewis antigen status depends on inheritance of the Lewis, Secretor, and H genes. Individuals can inherit genes allowing Lewis antigen secretion even if they do not secrete ABH antigens. The substances secreted and antigens present on red cells are determined by complex interactions between these inherited genes.

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    © All Rights Reserved
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    of 11

    OTHER BLOOD GROUP SYSTEM:

    Lewis blood group system


    INTRODUCTION:
    The lewis blood group system is not manufactured by the
    red blood cells.

    Lewis antigens are not synthesized by red cells, but


    incorporated into red cell membrane structure.

    The lewis antigens are manufactured by tissue cells and


    secreted into body fluid, then adsorbed onto the red cell
    membrane from plasma.

    Therefore lewis antigen is not an integral part of the


    membrane structure.

    lewis antigen development begin in the first week of birth


    and continue to 6 years.
    INHERITANCE:

    The lewis gene (Le) code for L-fucosyltransferase enzyme

    which add fucose sugar to the precursor substance one.

     fucose sugar added to the N-acetylglucosamine sugar.

    The Le gene is located in the short arm of the

    chromosome 19.

    Lewis antigen production depends not only on the


    inheritance of the lewis genes but also on the inheritance
    of the secretor gene and H genes.
    INHERITANCE:
    If a Le gene is inherited , Lea antigens are found in the
    secretions and are adsorbed onto the red blood cells regardless of
    the secretor status.
    Therefore, an individual can be a non-secretor of ABH and still
    secret Lea into the body fluids.
    If the Se gene is inherited in addition to Le gene, the lweis
    transferase converts the available H soluble structure to a Leb ,
    And the red cells adsorbs Leb instead of Lea
     If the gene inherited from both parents is le, no antigen
    structure is present on the red cells.
    SUMMARY OF LEWIS INHERITANCE AND
    BIOCHEMISTRY CONCEPTS:
    Lea and Leb are not alleles

    Le(a-b+) red blood cells arises from the inheritance of an Le,


    Se, and H gene.

    A person can be a nonsecretor (sese) and still secrete Lea into


    body fluid. Therefore, only antigens Lea are secreted by the
    tissue cells and subsequently adsorbed to re blood cells from
    plasma yielding the phenotype Le(a+b-).

    Lewis antigens found in the secretion are glycoproteins

    Lewis antigens found in the plasma are glycolipids.

    Red cells adsorb only glycolipids not glycoproteins, onto the


    membrane.
    Substances present in secretions and antigens present
    on red blood cells, depending on the Lewis, Sese, Hh,
    and ABH genes inherited.
    LEWIS ANTIBODIES:
    Antibodies to the lewis blood group antigen (anti- Lea and anti-
    Leb) are generally produced by Le(a-b-) persons.

    Lewis antibodies are considered naturally occurring because they


    are present without previous exposure to the antigen positive red
    cells.

    They are generally IgM, do not cross placenta and do not cause
    HDNF.

    Can activate complement. Therefore can cause hemolytic


    transfusion reaction.
    LEWIS ANTIBODIES:
    Anti- Lea is easily neutralized with plasma and body fluid
    secretion.
    Le(a-b+) person do not make Anti- Lea because:
    1. the Lea antigen structure is contained within the Leb
    antigen epitopes.
    2. Le(a-b+) persons have Lea substances in their plasma and
    saliva.
    The lewis antigens dissociate from the red cells as they
    adsorb. These antigen released into the plasma can
    neutralized any lewis antibodies present in the recipient
    plasma of Le(a-b-) persons.

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