Anesthesia For Awake Craniotomy

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ANESTHESIA FOR

AWAKE CRANIOTOMY
Introduction

 Allows mapping for resection of brain tumors near eloquent regions.


 Patient needs to be conscious and cooperative during testing.
 Benefits:
 Reduce length of stay
 Enhanced recovery
 Avoid risk of general anesthesia
 Reduce intensive care unit admissions
 Reduce resource utilization
Indications

 Functional cortical mapping of eloquent brain function.


 Enable tailored resection. To maximize extent of tumor resection and minimize the
risk of neurological deficit
 Electrophysiological mapping and recording.
 Localization of seizure foci. Minimize pharmacological interference.
 Improving perioperative outcomes.
 e.g. stereotactic biopsy, ventriculostomy, resection of supratentorial tumors.
Preoperative Management

 Preoperative history and physical exam.


 Preoperative airway evaluation.
 Limited access and options.
 Well-motivated, mature and cooperative patients.
 Contraindications:
 Patient’s refusal
 Severe claustrophobia
 High blood loss
 Anxiety disorder, emotional instability
 Confusion or somnolence
 Alcohol or drug abuse
 Chronic pain disorders
 Low pain tolerance
 Morbid obesity
 Obstructive sleep apnea
 Anticipated difficult airway
 Uncontrolled coughing
 Dyspnea when lying flat
 Avoid benzodiazepines.
 Continuation of antiepileptic drugs.
 Patient preparation.
Anesthetic Management

 Premedication
 Based on patient’s level of anxiety, neurologic status, comorbidities and plan.
 Monitoring
 Standard ASA (ECG, BP, pulse oximetry, O2 analyzer ETCO2 analyzer), processed
EEG, intraarterial catheter, CBD.
 Positioning
 Supine, semi sitting or lateral.
 Avoid extreme flexion and rotation of the head.
 Patient’s comfort is important.
 Local anesthesia
 Local infiltration at incision and pin site
 Scalp block (6 nerves)
 Use long acting LA (Bupivacaine, Levobupivacaine, Ropivacaine)
 Monitor for systemic LA toxicity.
 Pain during procedure despite adequate block.
 Manipulation of dura and dissection of temporalis muscle.

 Anesthetic technique choice


 Asleep – awake – asleep
 Asleep – awake
 Conscious sedation
Conscious sedation

 Aim for moderate sedation.


 Patient should respond purposefully to stimulation.
 Maintain airway, ventilation adequacy and hemodynamics stability.
 Avoid excessive sedation.
 Choice of medication:
 Avoid benzodiazepines.
 Propofol and remifentanil infusions allow for rapid titration of sedation depth.
 Dexmedetomidine to avoid respiratory depression and electrocorticography
interference.
Asleep Awake Asleep

 Induced with general anesthesia.


 Airway secured with ETT or supraglottic airway.
 Patient awakened once dura is open.
 General anesthesia induced again after mapping is complete.
 Choice of anesthetic agents:
 Hemodynamically stable.
 Allow for smooth transition to awake state.
 Propofol infusion with short acting opioids (e.g. remifentanil)
 Inhalational anesthesia
Airway Management

 Intubation, supraglottic airway and supplemental oxygen.


 Supraglottic airway facilitate smoother transition.
 Airway manipulation during transition may cause coughing or spasm.
 Reestablishment of airway control is challenging.
 Administration of supplemental oxygen from unsecured airway increase the
risk of airway fire from electrocautery.
Postoperative Care

 Postoperative disposition is institution specific.


 Routine ICU admissions not needed, and indicated for patients with significant
comorbidities or surgical complications.
 Extended PACU care followed by inpatient bed or same day discharge
possible.
 Monitor for postoperative neurologic deficits, seizures.
 Treat pain, nausea and vomiting.

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