Amino Acids

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AMINO ACIDS

AMINO ACIDS

 Are building blocks of protiens


 The key elements of an amino acid
are carbon (C), hydrogen (H), oxygen (O),
and nitrogen (N), although other elements
are found in the side chains of certain amino
acids.
 Join one to another by peptide bond to form
protein.
 Use to produce energy but primary job is
building protein
 Non protein building roles, such as forming
neurotransmitters and hormones
STRUCTURE
 Amino acids are organic compounds that
contain alpha carbon, amine (-NH2)
and carboxyl (-COOH) functional groups,
along with a side chain (R group) specific to
each amino acid.
TYPES OF AMINO ACIDS
 About 500 naturally occurring amino acids
are known (though only 20 appear in
the genetic code) and can be classified in
many ways.
 Divided as standard and non standard amino
acids
 Twenty of the proteinogenic amino acids are
encoded directly by triplet codons in
the genetic code and are known as
"standard" amino acids.
STANDARD AMINO ACIDS

FURTHER DIVIDED AS ESSENTIAL AND NON ESSENTIAL


AMINO ACIDS

 Essential amino  Non essential are


acids which are those which are
not produced by produced by our
our body. As a body even if we do
result, they must not get it from the
come from food. food we eat.
ESSENTIAL AND NON ESSENTIAL AMINO ACIDS

The 9 essential amino Nonessential amino acids


acids are: include:
1) Alanine
1) Histidine
2) Arginine
2) Isoleucine 3) Asparagine
3) Leucine 4) Aspartic acid
4) Lysine 5) Cysteine
6) Glutamic acid
5) Methionine
7) Glutamine
6) Phenylalanine 8) Glycine
7) Threonine 9) Proline
8) Tryptophan 10) Serine
11) Tyrosine
9) Valine
NON STANDARD AMINO ACIDS
 Do not take part in protein synthesis
 But many of them play important role in
body
 e.g. ornithine citruline
CLASSIFICATION ON THE BASE
OF “R” CHAIN
 Aliphatic R
groups are nonpolar and hydrophobic. Hydr
ophobicity increases with increasing number
of C atoms in the hydrocarbon chain.
CONTINUE
 The sulfur-containing amino acids (cysteine
and methionine) are generally considered to
be nonpolar and hydrophobic.
 An aromatic amino acid is an amino acid
that includes an aromatic ring.
Examples include:
Among 20 standard amino acids:
 Phenylalanine
 Tryptophan
 Tyrosine
CONTINUE
Imino acid
 Imino acids are a group of compounds that
contain both an amide and a carboxyl group,
bonded to the alpha carbon molecule.
 In proline, the R-group is bonded to the central
carbon as well as the nitrogen atom of the amino
group, forming a house-like structure, as seen
below. This makes proline unique in structure
among all other amino acids.
 Proline
Basic amino acid
 There are three amino acids that
have basic side chains at neutral pH. These
are arginine (Arg), lysine (Lys), and histidine
(His).
 Their side chains contain nitrogen and
resemble ammonia, which is a base. Their
pKa's are high enough that they tend to bind
protons, gaining a positive charge in the
process
CONTINUE
CONTINUE
Acidic amino acids
 Two amino acids have acidic side chains at
neutral pH. These are aspartic acid or
aspartate (Asp) and glutamic acid or
glutamate (Glu).
 Their side chains have carboxylic acid groups
whose pKa's are low enough to lose protons,
becoming negatively charged in the process
CONTINUE
CONTINUE

Nuetral amino acids


 Serine
 Threonine
 Asparginine
 glutamine

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