Homeostasis 2

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Homeostasis

Control of body temperature


Control of blood glucose level
IGCSE Biology
The importance of a constant temperature
Many biological and physical processes are affected by temperature.
For example:
• Enzymes work best at their optimum temperature, and are denatured
by wide deviations from this
• Cell membranes become fragile as temperature rises
• Diffusion rates are increased by higher temperatures, and decreased
by lower ones
• Liquids such as blood become more viscous(thicker) as the
temperature falls.
The importance of a constant temperature
Birds and mammals are endotherms(inside heat) – they can maintain a
constant body temperature by generating heat internally.
Humans have several mechanisms which work non-stop to balance
heat production against heat loss, as shown in the diagram below.
This balance is achieved by a temperature control centre in the
hypothalamus, a region of the brain.
An endothermic animal maintains an ideal body
temperature by balancing heat losses and heat gains.
The role of the skin
As the barrier between the body and its environment, the skin is also
the main organ concerned with heat loss and heat conservation.
The role of the skin
The role of the skin
The role of the skin
Control of blood glucose level
One of the functions of adrenaline is to increase the concentration of
glucose in the blood for respiration. However, constant high
concentration of glucose in the blood are harmful.
The ideal concentration of glucose in the blood is normally maintained
by two further hormones, Insulin and Glucagon. These are secreted by
cells in the pancreas in response to changes in blood glucose
concentration. They affect liver, fat tissue and muscle.
Control of blood glucose level
• Insulin – is released when blood sugar is too high. It stimulates the
removal of glucose from the blood.
• Glucagon - is released when blood sugar is too low. It stimulates the
release of glucose into the blood.
Control of blood glucose level
Insulin controls the conversion of glucose to glycogen.
Glucagon controls the conversion of glycogen to glucose.
• Glucose is a simple sugar and is soluble in blood plasma and cell
cytoplasm.
• Glycogen is polysaccharide and is insoluble.
Glucose is therefore the usable form of carbohydrate. The way in which
the blood glucose level is kept within safe limits is shown in the diagram
below.
Blood glucose level is under feedback control by
the hormones insulin and glucagon
Blood glucose level
Glucose is the cells’ main source of energy, and it must always be
available to them for respiration.
So the body keeps a constant amount of glucose in the blood. This
blood glucose level is usually maintained at about 1mg of glucose per
of blood.
What is diabetes?
Diabetes is a condition in which the blood concentration is higher than
normal.
Type I diabetes: is usually the result of the pancreas failing to secrete
enough insulin.

Symptoms include:
Excessive thirst, hunger or urine
production
Sweet smelling breath
High ‘overflow’ of glucose into
urine (test with Clinistix)
Type I diabetes
Long term effects if untreated include:
• Premature ageing
• Cataract formation (is a cloudy area in the lens of the eye that leads to a
decrease in vision)
• Hardening of arteries
• Heart disease.
Treatment is by regular injection of pure insulin – much of this id now
manufactured by genetic engineering.
Type II diabetes
A diet that contains too much fat and too much sugar can cause a form
of diabetes.
This Type II diabetes can be controlled by adjusting the diet to limit fat
and sugar, and does not need injection of insulin. This non-insulin
dependent diabetes is common problem of obese people.
Homework

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