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    Hypertriglyceridemia Icu

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    hypertriglyceridemia icu

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    Hypertriglyceridemia Icu

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    of 35

    Hypertriglyceridemia in

    the Intensive Care Unit


    Luke Dotson, PharmD
    January 16th, 2024
    Objectives
    • Review the structure, synthesis pathway, and function of
    triglycerides in the human body.
    • Understand the causes, complications, and treatment
    options for hypertriglyceridemia.
    • Interpret the assigned clinical trial and determine the
    applicability of the results.
    • Develop an action plan for addressing
    hypertriglyceridemia in the intensive care unit.
    What are triglycerides?
    About High Cholesterol. www.myhealthmylife.com.my.
    https://www.myhealthmylife.com.my/en-MY/Cardiovascular/High
    -Cholesterol/About-High-Cholesterol

    ‌
    Triglyceride Structure

    Triglycerides. Chemistry LibreTexts. Published June 27, 2016.


    https://chem.libretexts.org/Bookshelves/Introductory_Chemistry/Intro
    ductory_Chemistry_%28CK-12%29/26%3A_Biochemistry/
    26.08%3A_Triglycerides

    ‌
    How are triglycerides
    synthesized?
    Synthesis Pathway

    Triacylglycerol Metabolism - An Overview. Chemistry LibreTexts. Published August 5, 2017.


    https://chem.libretexts.org/Bookshelves/Introductory_Chemistry/Map
    %3A_Fundamentals_of_General_Organic_and_Biological_Chemistry_%28McMurry_et_al.
    %29/24%3A_Lipid_Metabolism/24.03%3A_Triacylglycerol_Metabolism_-_An_Overview

    ‌
    What Causes
    Hypertriglyceridemia?
    How to Lower High Triglycerides Naturally. Dr. Axe. Accessed January
    16, 2024. https://draxe.com/health/high-triglycerides/

    ‌
    Medication-Induced Dyslipidemia

    Herink M, Ito MK. Medication Induced Changes in Lipid and


    Lipoproteins. Nih.gov. Published May 10, 2018.
    https://www.ncbi.nlm.nih.gov/books/NBK326739/

    ‌
    Other Medications:
    Other Medications

    • Propofol
    • Clevidipine
    • Total Parenteral Nutrition (TPN)
    • Valproic acid
    • Olanzapine
    • Mirtazapine

    Herink M, Ito MK. Medication Induced Changes in Lipid and


    Lipoproteins. Nih.gov. Published May 10, 2018.
    https://www.ncbi.nlm.nih.gov/books/NBK326739/
    What are Complications
    of Hypertriglyceridemia?
    Duggal DD. Triglycerides Normal Range, Risk of High Levels, Causes,
    & Prevention. Breathe Well-Being. Published April 5, 2022.
    https://www.breathewellbeing.in/blog/triglycerides-normal-range-
    risk-of-high-levels-causes-prevention/
    How Should
    Hypertriglyceridemia be
    Treated?
    Hypertriglyceridemia Treatment

    UpToDate. www.uptodate.com. https://www.uptodate.com/contents/hypertriglyceridemia-in-adults-


    management/print
    Study Design
    Methods
    Heparin
    Insulin
    Fenofibrate
    Therapeutic Plasma
    Exchange
    Therapeutic Plasma Exchange

    Farkas J. PulmCrit- Hypertriglyceridemic pancreatitis: Can we defuse the


    bomb? EMCrit Project. Published March 13, 2017. Accessed January 16,
    2024. https://emcrit.org/pulmcrit/hypertriglyceridemic-pancreatitis/

    ‌
    Subjects
    Endpoints
    Statistical Analysis
    Results
    Strengths
    Limitations
    Clinical Relevance and
    Applicability
    What would YOU do?
    References
    1. Ozcelik S, Baş S, Ozcelik M, Sarıaydın M, Celik M, Gözü H. Efficacy of insulin, heparin, and fenofibrate combination treatment
    in severe hypertriglyceridemia: double center experience. Acta Endocrinol (Buchar). 2019;15(4):460-465.
    doi:10.4183/aeb.2019.460
    2. About High Cholesterol. www.myhealthmylife.com.my. https://www.myhealthmylife.com.my/en-MY/Cardiovascular/High-
    Cholesterol/About-High-Cholesterol
    3. 26.8: Triglycerides. Chemistry LibreTexts. Published June 27, 2016.
    https://chem.libretexts.org/Bookshelves/Introductory_Chemistry/Introductory_Chemistry_%28CK-
    12%29/26%3A_Biochemistry/26.08%3A_Triglycerides
    4. Triacylglycerol Metabolism - An Overview. Chemistry LibreTexts. Published August 5, 2017.
    https://chem.libretexts.org/Bookshelves/Introductory_Chemistry/Map
    %3A_Fundamentals_of_General_Organic_and_Biological_Chemistry_%28McMurry_et_al.%29/24%3A_Lipid_Metabolism/
    24.03%3A_Triacylglycerol_Metabolism_-_An_Overview
    5. How to Lower High Triglycerides Naturally. Dr. Axe. Accessed January 16, 2024. https://draxe.com/health/high-triglycerides/
    6. Herink M, Ito MK. Medication Induced Changes in Lipid and Lipoproteins. Nih.gov. Published May 10, 2018.
    https://www.ncbi.nlm.nih.gov/books/NBK326739/
    7. Duggal DD. Triglycerides Normal Range, Risk of High Levels, Causes, & Prevention. Breathe Well-Being. Published April 5,
    2022. https://www.breathewellbeing.in/blog/triglycerides-normal-range-risk-of-high-levels-causes-prevention/
    8. ‌UpToDate. www.uptodate.com. https://www.uptodate.com/contents/hypertriglyceridemia-in-adults-management/print

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