Kepi, Immunization
Kepi, Immunization
Kepi, Immunization
IMMUNIZATION
(K.E.P.I)
BY
JANE RABURU
OBJECTIVES
KEPI:
ATTENUATED:
IMMUNE- COMPLEX:
Its also known as antigen-antibody complex, occurs from the bonding of an
antibody to an antigen. immune complex molecules help in fighting diseases.
ANTIBODY-
its a protein produced by the body’s immune system when it detects harmful
ANTIGEN-
Its any substance that causes your immune system to produce antibodies against
it. An antigen maybe a foreign sunstance from the environmentsuch as
Vaccine Vial Monitor:
exposed to heat.
Its a tool that tells you when the vaccine has been exposed to freezing
temperatures. It is useful in detecting vaccines such as DPT, TT, HEP B
that should not be frozen
2. Eradication of poliomyelitis
4. Control of measles.
TYPES OF IMMUNIZATION
1. Active immunisation
2. Passive immunisation
3. Natural immunisation
3. Artificially induced immunisation
1. ACTIVE IMMUNIZATION
3. Giving immunizations
5. Record keeping
b) Follow- up- campaign –one dose of measles vaccine to children born since
the catch –up campaign
c) Mopping up- where poor coverage was achieved in the catch-up or follow-
up campaign, or when epidemiology evidence suggests measles
transmission is focalized.
BCG 1
Polio 4
Pentavalent 3
PCV 3
Rota 2
Measles 2
Yellow fever 1
Tetanus Toxoid for women of child bearing age (15-
49 years) 5
IMMUNIZATION SCHEDULE
Age ANTIGEN
At birth BCG and Birth OPV
6 weeks DPT/HepB/Hib 1 and OPV 1
8 weeks ROTA 1
10 weeks DPT/HepB/Hib2 and OPV2,
14 weeks DPT/HepB/Hib 3 and OPV 3
4 months ROTA 2
6 months VIT A , Rota 3
9 months Measles
9 months Yellow Fever (in the four endemic districts of
Baringo, Koibatek,Keiyo and Marakwet).
18 months 2 nd measles
ESSENTIAL ELEMENT FOR MAINTAINING VACCINES POTENCY
The term vaccine derives from Edward Jenner's1796 use of the term
cow pox (Latin variolæ vaccinæ, and vacca=cow), which, when
administered to humans, provided them protection against
smallpox.
"remember“
media.
VACCINES DEVELOPMENT
1. Mono-vaccines measles
2. Combined or polyvalent DPT
3. Bacterial vaccine – vaccines against cholera
pertussis
4. viral vaccines – OPV and vaccines
against measles ,
mumps rubella ,yellow fever
5. Liquid vaccines: DPT, Polio vaccines
6. Lyophilized (dry) vaccines: BCG, Measles
CHARACTERISTICS OF IDEAL VACCINES
Once it has been diluted, the vaccine loses its potency very quickly
and must be discarded after six hours (6HOURS)
BCG vaccine is given in a single dose at birth or first
contact.
Clean the skin with dry cotton wool soaked in clean water and
let it dry.
Hold the middle of the child's upper right arm firmly with your
left hand.
Hold the syringe by the barrel with the millilitre scale upward
Gently insert its tip into the upper layer of the skin.
Holding the barrel with your index and middle finger, put
Change the syringe and needle after each antigen (vaccine) and
each child.
The sore might ooze a bit and will last for 6 to 8 weeks.
Use the diluent provided for each vaccine. Diluent should be cold: +4 -
+8 degrees centigrade.
Use different 5ml syringes for mixing measles and BCG vaccines.
Draw and expel mixture back into the bottle three times or until the
vaccine is mixed.
Do not shake the vial.
The oral polio vaccine contains live attenuated virus from all three types of polio.
Place the vial on a frozen ice pack or place it in the hole of the
sponge placed at the mouth of a vaccine carrier, which is
provided for this purpose to maintain the temperature.
3. PENTAVALENT
This is the newly introduced combination of immunisation against
diphtheria, pertussis (whooping cough), tetanus, hepatitis B and
influenza.
The first dose is given six weeks after birth, the 2nd at ten weeks
after birth and 3rd at the age of 14 weeks
Pentavalent has five vaccines which include
diphtheria, pertussis, tetanus, and hepatitis B and
Haemophilus influenza type B.
1. DPT may cause some tenderness at the place the injection was
given.
3. DPT may cause fever but the fever will subside in 24 hours.
Remove bubbles
in a dose of 0.5ml.
It has been noted that some children still suffer from measles in
spite of the fact that they were vaccinated.
2. The vaccine may have expired or may have been kept at the wrong
temperature
3. The child may have been vaccinated while still too young thus having
their mother’s antibodies still in their blood
4. The parents may have misreported some rashes and pyrexia, which
appear similar to measles yet it is not
CONTRA-INDICATION OF MEASLES
Rabies vaccine is given to people at high risk t protect them if they are
exposed. The vaccine is made from killed rabies virus and is administered
intramuscularly.
Dose 1: as appropriate
1. Never take two vials of the same vaccine out of the vaccine
carrier at the same time.
2. Do not mix vaccines until mothers and children are present.
3. Mix one vial of a particular vaccine at a time
4. Keep opened vials of polio, measles, and BCG vaccines on a
frozen ice pack or use the sponge in the vaccine carrier. Their
temperature must be carefully maintained.
5. Do not keep vials of pentavalent and TT vaccines directly on
the frozen ice pack.
6. Open the vaccine carrier only when necessary.
7. Use one sterile syringe and needle per vaccine per child or
mother.
9. Inform each parent what type of vaccine you are giving the
child, the possible reactions to it, what to do about the reactions,
and when to bring the child back for more immunisation.
11. Remove any child’s clothes that are in your way when
vaccinating
During immunisation you should:
IMMUNISATION (AEFI)
INTRODUCTION
Specific Objectives:
1. Define AEFI
2. How to identify AEFI
3. State the possible causes of AEFIs.
4. To detect and report AEFI
5. State the steps involved in investigating adverse
events.
6. Outline the steps taken in managing AEFI cases.
7. Describe how to prevent cases of AEFI.
DEFINITION AEFI
1. Anaphylactic shock
2. Injection site abscesses.
3. Cases of BCG lymphadenitis
4. Cases requiring hospitalizations that are thought
by health workers, or the public, to be related
immunization
5. Unusual medical incidents that are thought by
health workers, or the public, to be related to
immunization.
6. Deaths that are thought by health workers, or the
public, to be related to immunization.
In routine surveillance the health worker is expected
How to identify AEFI
The cardinal signs of anaphylaxis are:
• Itchy, urticarial rash (in over 90% of cases)
• Progressive, painless swelling (angioedema) about the face and the
mouth, which may be preceded by itchiness, tearing, nasal
congestion or facial flushing
• Respiratory symptoms, including sneezing, coughing, wheezing,
and laboured breathing; upper way swelling (indicated by hoarseness
and/of difficulty swallowing) possibly causing airway obstruction
• Hypotension, which generally develops later in the illness and can
progress to cause shock and collapse.
It must be differentiated from fainting, anxiety and breath holding
which are more common and benign reactions.
Who does AEFI data Analyses?
All the effort so far is wasted if action is not taken to correct the
error. If an AEFI was caused by programme error, such as
improper handling of vaccines or faulty immunization technique,
the actions to be taken will probably include one or more of the
following:
• Logistics: Improving logistics will be the appropriate response
if investigations indicate lack of supplies or equipment or failure
of the cold chain.
• Training: Trainings often used to solve operational problems:•
Supervision: Non-serious AEFIs (e.g. abscesses) reported to the
health facility should be able to alert the health worker to seek
for the cause for immediate corrective action.
• Communication: Health workers should inform parents and
the community about AEFIs,
VACCINES MANAGEMENT
The effectiveness and success of KEPI in reducing the
burden of immunization preventable diseases depends
on the quality of vaccines at the point of use, which in
turns reflects the usefulness of the vaccine
management system.
population categories
1. Target population
2. Previous consumption
a. Target population
b. Immunization schedule
Doses spoilt for one reason or the other e.g. VVM reached discard point,
breakdown in the cold chain, frozen DTP+ HepB and TT or removed labels.
1. Wastage rate
2. Wastage factor
1. Vaccine wastage rate
Vaccine wastage rate should be taken into account in the
estimation of vaccine needs. Knowing the wastage rates
helps to determine the wastage factor, which is one of the
parameters used to estimate vaccine needs.
Formula:
period.
The needs for a specific storage or supply period can be calculated as follows:
Vaccines needs for the period = Annual vaccines needs X Supply period (in
months)
Number of months in year
Where,
Qperiod = Vaccines needs for the period
Qyear = Annual vaccines needs
Psupply = Supply period (in months)
Example: using Kasei Health Facility
CHECK PGS 32/33 (greenbook)
The “minimum stock” represents the minimum number of vaccine doses that
should be in the refrigerator
on the arrival of the next supply consignment. The level of minimum stock is
generally fixed at 25% of the total estimate of vaccines needs for a given supply
period.
Using a formula
Note: the minimum stock takes into account the possible delays in supply as
well as unexpected increase in the population to be immunized (untargeted
population, migration, etc.).
Calculating maximum stock
level
The maximum stock is the maximum number of vaccine doses that
should be found in the refrigerator after a supply.
Example
1. Compression
2. Absorption
1. COMPRESSOR
COMPRESSION
RCW 42EG
ABSORPTION
Sibir S2323
RA 1300
VR 50 solar
PACKINGING
The vaccines are placed such that polio, measles ,BCG are in the
coolest part of the refrigerator .Penta,TT,PCV10 should be in the
middle
same time
Check temp BD
2. Weekly
3.monthly
Orders should be placed for any spares parts required for the proper function of the cold room.
Types of thermometers used in cold chain
1. Liquid crystal: used during transportation, do not operate at temp
below freezing point
protected.
2. Refrigerators are used mainly for storage at the health facility level.
4. Vaccine carriers are only used for temporally storage during short
distance transportation and service delivery.
5. Ice packs are needed to maintain low temperature in cold boxes and
vaccine carriers and placement of vaccines during service delivery.
You have to ensure that you handle the vaccines as per their
different and specific characteristics.
4. Shake Test
This is a simple test that can be easily done at every stage of the cold chain and is used
mostly in testing TT vaccines.
The sedimentation rate of a suspect vial is compared with a similar Tetanus Toxiod vial
that is known to have been stored at the correct temperature.
Shake the two vials vigorously and inspect carefully in strong light .
5. Vaccine Vial Monitor (VVM)
A vaccine vial monitor (VVM) is a label made of heat –
sensitive material that is placed on a vaccine vial to register
cumulative heat exposure over time.
The combined effects of time and temperature cause the
monitor to change colour gradually and irreversibly. VVM can
be used on vaccine vials or the ampule.
Vaccine vial monitor showing
no heat exposure
elsevier.London
www.e-medicine.com
ORGANIZING FOR
IMMUNIZATION
OBJECTIVES
• For smooth floor two doors are ideal, one for entry and the other for
the exit.
• Guide the parent / guardian into a single queue to enter the MCH
area. Ensure a first-come first served system.
• When the parents /guardians are through at MCH clinic thank him/
her for coming.
THE HEALTH FACILITY SHOULD HAVE
• Waiting area where parents and guardian can sit before
being immunized as they receive health talks; as the talks will
be better received if people are comfortably seated in the
waiting bay.
• Two chairs/stools; one for the parent or guardian, one for the
health worker.
Set up separate station for each of these services,
which include.
• An area for health education
• Treatment
• Antenatal care
• Expectant women,
topics
• Immunization
• Nutrition
• Family planning
• Personal hygiene
• Other relevant health topics e.g. PMTCT, VCT, Malaria control, ITNs etc.
WEIGHING
• Foam pads on top of the ice packs in the vaccine carrier to keep
the vaccines cold.
• AEFI form.
• Take out from refrigerator all vaccines you will need for the session and put
them in a vaccine carrier
• Ensure that the vaccine carriers are closed all the time.
• Check all children to see what immunizations they have had and what they
are due for
• If in doubt, ask the parents/guardians and confirm from
the card
• On the other hand, even if the time limit is long past the
minimum interval of 4 weeks give the next dose
• Tell mothers about the reaction to expect from immunizations. Many mothers
may have heardrumours. Reassure and tell them what to expect and how to
respond
• USE ONLY ONE STERILE SYRINGE AND NEEDLE FOR EACH INJECTION.
After use, dispose it into safety box immediately at the point of use.
• After the clinic session, take all tally sheets and fill in the monthly summary
sheet. Clean and tidy up the clinic before you go off duty, ready for the next
day.
OUTREACH/ MOBILE SERVICES
Organization:
• Make sure that you keep vaccines cold (+2o to +8o degrees Centigrade).
• When you arrive, arrange your mobile or outreach clinics similar to that of
your static health facility
• Once the immunization session starts, open your cold box or vaccine
carrier once, take the vaccines you need according to the number of
mothers and children expected and put them on holes in the sponge which is
replaced on vaccine carrier during the session, replace ice packs as soon as
the ice has melted. Carry a spare vaccine carrier/cold box with icepacks for
replacement.
• Complete the immunization tally sheet and remember to transfer the data
and the name of the outreach clinic to the immunization summary sheet
REACHING THE TARGET
POPULATION USING THE
RED APPROACH
(REACH EVERY CHILD)
TARGET POPULATION GOT REC
APPROACH
Unvaccinated children
Unvaccinated mothers
RED APPROACH IMPLEMENTATION
FRAME WORK
COMPILE POPULATION & COVERAGE
FOR SUB-COUNTY LEVEL
Measles = or
Good coverage
over 90%
Coverag
e
Good
Drop out rate
utilization
below 10%
Utilizatio
n
A c c e s s to im m u n is atio n se rv ic es
Interpretation
Compile, District
Analyze and Microplanin
Prioritize
g
Plannin
g County (district) Level
Health Facility
Micro planning:
Compile, Analyze
Prioritize and Plan
Reaching the Target Population
Could it be:
Where to focus
To be realistic - 10 facilities