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    Histology of The Ovary Lecture

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    Charles Ozochukwu

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    Histology of The Ovary Lecture

    Uploaded by

    Charles Ozochukwu
    1 views26 pages

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    Histology of the Ovary Lecture

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    1 views26 pages

    Histology of The Ovary Lecture

    Uploaded by

    Charles Ozochukwu

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 26

    HISTOLOGY OF THE OVARY

    BY

    DR KELECHI DURUH
    DEPARTMENT OF HUMAN
    ANATOMY
    FBMS COLLEGE OF MEDICINE
    1
    UNEC
    INTRODUCTION
    • Ovary is a paired almond shaped female
    reproductive and endocrine organ.
    • Located in the pelvis
    • Lateral to the uterus
    • Measures about 3cm long,1.5cm wide, and
    1cm thick
    • Develops from the gonodal primordia

    2
    INTRODUCTION

    3
    INTRODUCTION
    • Development and growth of the ovary is
    dependent on Gonadotrophin hormones(FSH
    and LH)
    • Follicular development depends on FSH
    • Theca interna secretes androstenedione
    • Androstenedione is converted into estradiol
    by aromatase in the granulosa cells
    • Granulosa cells secretes inhibin

    4
    INTRODUCTION

    Schematic diagram of hormonal control of the ovary 5


    INTRODUCTION
    • Granulosa cells secretes postaglandin
    • Theca lutein cells produce large amount of
    progesterone and androstenedione under the
    influence of LH
    • The consequence of decreased progesterone from
    corpus luteum of menstruation is menstruation
    • If oocyte is fertilized, corpus luteum lingers about
    4-5months when trophoblasts has established
    HCG secretion

    6
    FOLLICULAR GROWTH AND DEVELOPMENT

    • At puberty, FSH commence cyclical stimulation of a


    group of primordial follicles each cycle
    • This causes growth and proliferation of follicular cells
    and ovarian stroma
    • Different points of development casts various shades
    on the histology of the ovary
    • The dominant follicle develops to mature or graafian
    follicle
    • Other follicles in the group stimulated initially
    undergo atresia
    7
    FOLLICULAR GROWTH AND DEVELOPMENT

    SHEMATIC DRAWING OF FOLLICULAR GROWTH 8


    FOLLICULAR GROWTH AND DEVELOPMENT

    STAGES OF DEVELOPMENT OF OVARIAN FOLLICLE : H/E

    9
    FOLLICULAR GROWTH AND DEVELOPMENT

    STAGES OF DEVELOPMENT OF OVARIAN FOLLICLE : H/E

    10
    FOLLICULAR GROWTH AND DEVELOPMENT

    • The surrounding stroma differentiates to theca interna and


    externa
    • The primary oocyte completes meiosis 1 shortly before
    ovulation to become secondary oocyte
    • First polar body is produced
    • Secondary oocyte enters meiosis 11 and arrested in
    metaphase
    • The granulosa cells are redistributed to form the cumulus
    oophorosus and the corona radiata
    • Zona pellucida developes between the oocyte and first
    layer of granulosa cells
    11
    FOLLICULAR GROWTH AND DEVELOPMENT

    SCHEMATIC DIAGRAM FOLLICULAR DEVELOPMENT 12


    OVULATION

    • The release of the oocyte from the ovary.


    • Usually occurs about 14th day of the cycle.
    • The graafian follicle bulges on the ovary
    causing a stigma
    • Granulosa cells produce more follicular fluid
    containing prostaglandins and other
    macromolecules

    13
    OVULATION

    • Smooth muscles in the theca externa are


    stimulated
    • Contraction expels the oocyte
    • After ovulation the follicle collapses
    • The ovulated follicle and theca interna form a
    temporary endocrine gland called corpus
    luteum

    14
    OVULATION

    PREOVULATORY ANTRAL FOLLICULE: H/E AND PT 15


    OVULATION

    • The cells of the theca and granulosa change


    histologically and functionally under the
    influence of LH
    • Corpus luteum of menstruation last for 12-14
    days
    • Corpus luteum of pregnancy last 4-5months
    • The scar of corpus luteum is called corpus
    albicans

    16
    CLINICAL CORRELATES
    • Polycystic ovarian syndrome: characterized by
    bilateral multiple ovarian cyst and anovulatory
    state.
    • Hemorrhagic cyst: bleeding into a follicular cyst
    • Ovarian failure: could be primary or secondary.
    The ovary is not producing oocytes
    • Miscarriage from insufficient progesterone
    secretion by corpus luteum of pregnancy

    17
    IDENTIFY

    18
    IDENTIFY

    19
    IDENTIFY

    20
    IDENTIFY

    21
    IDENTIFY

    22
    IDENTIFY

    23
    IDENTIFY

    24
    NDEWO NU

    25

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