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    1 Introduction to ANS

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    1 Introduction to ANS

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    Download as ppt, pdf, or txt
    3 views24 pages

    1 Introduction to ANS

    Uploaded by

    mustaphakehinde586

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
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    Introduction to ANS

    Prof (Dr) Mohamed Samai


    Bsc (Hons), Msc, MBBS,
    PGCRM, PhD
    Head, Department of
    Pharmacology
    COMAHS, USL.
    Overview

     Divisions of the Nervous system


     Somatic vs. ANS
     Divisions of the ANS
     Anatomical differences b/t SNS and PNS
     Receptors, Neurotransmitters and Second
    Messengers
     Physiological Differences b/t SNS and PNS
     Steps involved in autonomic neurotransmission
    Nervous System
    Sympathetic Parasympathetic

    brainstem
    cranial
    nerves

    thoracic

    lumbar

    sacral

    nciples of Neural Science, 3rd Ed. Kandel et al., p. 763


    Autonomic Nervous System

     General Functions
    Autonomic Nervous System
    Synaptic Connectivity Voluntary vs. Autonomic Nerves

    visceral
    effectors
    Somatic motor system Autonomic motor system
    central nervous smooth
    central nervous autonomic
    system muscle
    somatic system ganglion
    motor neuron
    gland
    cells
    skeletal preganglionic postganglionic
    muscle fiber cardiac
    fiber
    muscle
    dorsal

    ventral

    nciples of Neural Science, 3rd Ed. Kandel et al., p. 762


    Synaptic Transmission in Autonomic Ganglia

    Preganglionic neurons release acetylcholine

    Postganglionic Cell Receptors


    Neuronal Nicotinic Receptors N
    N
    Different pharmacology from muscle Nicotinic
    Receptors NM
    Cation-selective channel

    Muscarinic (GPCR) receptors


    Autonomic Receptors
    Adrenoceptors
    Sympathetic Parasympathetic

    Primary norepinephrine
    acetylcholine
    Neurotransmitter epinephrine (~20%)

    Receptors Adrenergic GPCRs Muscarinic GPCRs


    & 1 – IP3/DAG, [Ca2+]i PKC M1 – IP3/DAG, [Ca2+]i PKC
    Second 2 - cAMP/PKA M2 – cAMP/PKA, PI(3)K
    Messenger M3 – cAMP/PKA,
    Systems 1 - cAMP/PKA IP3/DAG, [Ca2+]i PKC
    2 - cAMP/PKA M4 –
    3 - cAMP/PKA M5 – IP3/DAG, [Ca2+]i PKC

    Adrenal Medulla
    (epi:norepi::80:20)
    Steps involved in autonomic
    neurotransmission

    • Synthesis
    • Storage
    • Release
    • Interaction with receptors
    • Termination of action
    Synthesis of
    adrenaline
    Pharmacologic manipulation of the cholinergic system
    Pharmacologic manipulation of the adrenergic system
    Na+
    Presynaptic neuron
    Tyrosine
    Na+
    Dopamine
    Tyrosine

    Action Potential
    H+ O
    DA MA

    NE NE
    Ca2+
    Uptake 1
     (-) Na+, Cl-
    NE
    NE NE NE
    Uptake 2

     
    Effector organ
    Thank you very
    Much

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