I feel robbed of a different George O'Malley
George O'Malley had the potential, as a character, to be so much more. We could've seen a depth to his disconnection to his heavily masculine, Republican, Catholic family that went beyond "I don't like hunting and I went to college". We could've seen him struggle for more than one reason against his father's wish for him to be with Callie. We could have seen a conclusion to the dead-end jokes and heavy queercoding that defined his early appearances.
George O'Malley should have been gay. I know that it's a tall ask to expect a show that debuted 17 years ago to introduce a fully normalised LGBTQ main character with no stigma or snidery attached, but Grey's has always stood out to me as one of the more progressive shows with a lot of topics raised ahead of their time. Rather than cheat on Callie because of a horribly-written affair with Izzie, George and Callie could have mutually worked out why their relationship wasn't working and gone down a path that also helped Callie come to terms with her own bisexuality when the time came.
George O'Malley should have survived. I'm not going to deny the show dramatic license or pretend I don't know why things soured BTS, but it still stands for me. George could have spent Season 6 in deep recovery, but survived. He could have been permanently physically disabled and gone on to thrive outside his medical career; he was always the one on the fence about his passion and capability in the field, right? There's something in that. George was hoping to specialise in trauma. He knows what it's like growing up feeling outcast. I would have liked to see him the role of a carer, a fixer; someone who mentors young people in the position he was in. He could have worked with LGBTQ and/or disabled young people interested in the medical field. It would have been interesting to watch the career progression of a principal character outside of just going up or down the surgical chain.
On a more superficial note, I would have liked to see a male love interest introduced for George either before or after the accident. It would have tangled canon by introducing a new character at that point, but with the amount that come and go it would certainly have been doable.
And yeah, it's likely the character would phase out of screentime a couple of seasons in. But I would have still been satisfied with just the knowledge that somewhere in canon there's a gay, disabled, happily married man living not so far away from the hospital, living a life with more fulfilment than the surgical field ever seemed to give him.