State of the science: an update on renal cell carcinoma (Q24630685)

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P Andrew Futreal

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Ian J Davis

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Sean T Bailey

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William Y Kim

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James Brugarolas

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Amato J Giaccia

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Ghada Kurban

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Armin Pause

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Judith Frydman

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Amado J Zurita

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Brian I Rini

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Pam Sharma

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Michael B Atkins

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Cheryl L Walker

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W Kimryn Rathmell

original language of film or TV show

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English

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publication date

July 2012

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published in

Molecular Cancer Research

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volume

10

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issue

7

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page(s)

859-80

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cites work

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

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mTOR: from growth signal integration to cancer, diabetes and ageing

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

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A gene network regulating lysosomal biogenesis and function

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VHL type 2B mutations retain VBC complex form and function

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

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NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL

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Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases

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HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

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Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

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Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth

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Gene expression profiling predicts survival in conventional renal cell carcinoma

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

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Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America

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Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation

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Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

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Selectivity of chromatin-remodelling cofactors for ligand-activated transcription

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

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Immunotherapy for advanced renal cell cancer

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Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

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Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

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TSC2 mediates cellular energy response to control cell growth and survival

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Targeting HIF-1 for cancer therapy

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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Ciliogenesis: building the cell's antenna

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Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex

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Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription

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Ipilimumab plus dacarbazine for previously untreated metastatic melanoma

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PD-1 and its ligands in tolerance and immunity

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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

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The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma

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Sorafenib in advanced clear-cell renal-cell carcinoma

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Sunitinib versus interferon alfa in metastatic renal-cell carcinoma

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Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study

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Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein

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Mitochondrial tumour suppressors: a genetic and biochemical update

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

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A role for mitochondrial enzymes in inherited neoplasia and beyond

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Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome

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A gene hypermethylation profile of human cancer

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Loss of PTEN facilitates HIF-1-mediated gene expression

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Enhancement of antitumor immunity by CTLA-4 blockade

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CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

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Hypoxia upregulates the histone demethylase JMJD1A via HIF-1

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Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

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Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice

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