Xanthine dehydrogenase (Q1436420)

FAD-binding, type PCMH-like superfamily

1 reference

[2Fe-2S]-binding domain superfamily

1 reference

Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily

1 reference

CO dehydrogenase flavoprotein, C-terminal domain superfamily

1 reference

2Fe-2S ferredoxin-like superfamily

1 reference

Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily

1 reference

2Fe-2S ferredoxin-type iron-sulfur binding domain, protein family

1 reference

Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead, protein family

1 reference

Molybdopterin dehydrogenase, FAD-binding domain, protein family

1 reference

[2Fe-2S]-binding domain, protein family

1 reference

Xanthine dehydrogenase, small subunit, protein family

1 reference

CO dehydrogenase flavoprotein, C-terminal domain, protein family

1 reference

FAD-binding domain, PCMH-type, protein family

1 reference

Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain, protein family

1 reference

2Fe-2S ferredoxin, iron-sulphur binding site, protein family

1 reference

Oxidoreductase, molybdopterin binding site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

1 reference

8 April 2019

protein homodimerization activity

IPI

1 reference

8 April 2019

Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

xanthine oxidase activity

IPI

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

1 January 2018

1 January 2018

Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

1 January 2018

Cloning and expression in vitro of human xanthine dehydrogenase/oxidase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

1 January 2018

Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

EXP

1 January 2018

Cloning and expression in vitro of human xanthine dehydrogenase/oxidase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

flavin adenine dinucleotide binding

EXP

oxidoreductase activity, acting on CH-OH group of donors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

1 reference

31 October 2017

catalytic activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

1 reference

31 October 2017

molybdopterin cofactor binding

electron transfer activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

1 reference

8 April 2019

xanthine dehydrogenase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

31 October 2017

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

31 October 2017

Cloning and expression in vitro of human xanthine dehydrogenase/oxidase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

oxidoreductase activity

2 iron, 2 sulfur cluster binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

8 April 2019

8 April 2019

Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

oxidoreductase activity, acting on the aldehyde or oxo group of donors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

1 reference

31 October 2017

xanthine dehydrogenase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

8 April 2019

Cloning and expression in vitro of human xanthine dehydrogenase/oxidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

flavin adenine dinucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

3 references

8 April 2019

8 April 2019

Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

FAD binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

1 reference

8 April 2019

xanthine oxidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

8 April 2019

8 April 2019

Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

8 April 2019

Cloning and expression in vitro of human xanthine dehydrogenase/oxidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

1 reference

8 April 2019

peroxisome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

1 reference

8 April 2019

sarcoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

1 reference

8 April 2019

extracellular space

1 reference

31 October 2017

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

positive regulation of p38MAPK cascade

biological process

1 reference

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

negative regulation of protein phosphorylation

1 reference

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

negative regulation of protein kinase B signaling

1 reference

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

purine nucleotide catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

1 reference

8 April 2019

negative regulation of endothelial cell differentiation

TAS

1 reference

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

negative regulation of gene expression

1 reference

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

negative regulation of endothelial cell proliferation

1 reference

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

positive regulation of reactive oxygen species metabolic process

1 reference

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

negative regulation of vasculogenesis

1 reference

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

negative regulation of vascular endothelial growth factor signaling pathway

1 reference

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

lactation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

regulation of epithelial cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

xanthine catabolic process

2 references

31 October 2017

Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

31 October 2017

Cloning and expression in vitro of human xanthine dehydrogenase/oxidase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P47989&geneProductId=UniProtKB:P47989

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

electron transport chain

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

xanthine catabolic process

Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

8 April 2019

Cloning and expression in vitro of human xanthine dehydrogenase/oxidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47989

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

6795

language of work or name

English

object of statement has role

17 August 2016

topiroxostat

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1078685

Gene Atlas image

PBB GE XDH 210301 at fs.png
732 × 530; 12 KB

0 references

has part(s)

Molybdopterin dehydrogenase, FAD-binding

1 reference

2Fe-2S ferredoxin-type iron-sulfur binding domain

1 reference

Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead

1 reference

Oxidoreductase, molybdopterin binding site

1 reference

Xanthine dehydrogenase, small subunit

1 reference

Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding

1 reference

FAD-binding domain, PCMH-type

1 reference

CO dehydrogenase flavoprotein, C-terminal

1 reference

[2Fe-2S]-binding

1 reference

2Fe-2S ferredoxin, iron-sulphur binding site

1 reference

inferred by common MeSH mappings on source and on Wikidata

Identifiers

MeSH descriptor ID

D014968

subject named as

Xanthine Dehydrogenase

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

28 October 2013

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

1 reference

UMLS 2023