GTP cyclohydrolase 1 (Q1487359)

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mammalian protein found in Homo sapiens
  • GTP cyclohydrolase I
  • dystonia 14
  • GCH1
  • guanosine 5'-triphosphate cyclohydrolase I
  • GTP-CH-I
edit
Language Label Description Also known as
English
GTP cyclohydrolase 1
mammalian protein found in Homo sapiens
  • GTP cyclohydrolase I
  • dystonia 14
  • GCH1
  • guanosine 5'-triphosphate cyclohydrolase I
  • GTP-CH-I

Statements

image
Protein GCH1 PDB 1fb1.png
930 × 939; 590 KB
0 references
molecular function
protein binding
determination method or standard
IPI
5 references
retrieved
8 April 2019
stated in
A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IPI
retrieved
8 April 2019
stated in
GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IPI
retrieved
8 April 2019
stated in
A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IPI
GTP cyclohydrolase I activity
determination method or standard
IEA
IDA
TAS
10 references
retrieved
24 April 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
TAS
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IEA
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IEA
retrieved
24 April 2018
stated in
GTP cyclohydrolase I mRNA: novel splice variants in the slime mould Physarum polycephalum and in human monocytes (THP-1) indicate conservation of mRNA processing
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
24 April 2018
stated in
GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
24 April 2018
stated in
Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
24 April 2018
stated in
The application of 8-aminoguanosine triphosphate, a new inhibitor of GTP cyclohydrolase I, to the purification of the enzyme from human liver
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
24 April 2018
stated in
Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
24 April 2018
stated in
Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IDA
GTP cyclohydrolase I activity
determination method or standard
IBA
IDA
IEA
TAS
8 references
retrieved
10 September 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
TAS
retrieved
10 September 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IEA
retrieved
10 September 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IEA
retrieved
10 September 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IEA
retrieved
10 September 2018
stated in
GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
10 September 2018
stated in
Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
10 September 2018
stated in
Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IBA
GTP cyclohydrolase I activity
determination method or standard
IBA
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IEA
retrieved
8 April 2019
stated in
GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
8 April 2019
stated in
Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
8 April 2019
stated in
Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IBA
cell component
biological process
positive regulation of nitric-oxide synthase activity
determination method or standard
IDA
IMP
4 references
retrieved
8 April 2019
stated in
Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IMP
retrieved
8 April 2019
stated in
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IMP
retrieved
8 April 2019
stated in
Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
8 April 2019
stated in
GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IDA
tetrahydrobiopterin biosynthetic process
determination method or standard
IDA
IEA
IMP
5 references
retrieved
24 April 2018
stated in
Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IMP
retrieved
24 April 2018
stated in
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IMP
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IEA
retrieved
24 April 2018
stated in
Cytokines stimulate GTP cyclohydrolase I gene expression in cultured human umbilical vein endothelial cells
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
24 April 2018
stated in
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793
determination method or standard
IDA
tetrahydrobiopterin biosynthetic process
determination method or standard
IBA
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IMP
retrieved
8 April 2019
stated in
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IEA
retrieved
8 April 2019
stated in
Cytokines stimulate GTP cyclohydrolase I gene expression in cultured human umbilical vein endothelial cells
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
8 April 2019
stated in
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP
GOA
curator
UniProt
UniProt protein ID
P30793
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793
determination method or standard
IBA
Gene Atlas image
PBB GE GCH1 204224 s at fs.png
732 × 530; 10 KB
0 references

Identifiers

 
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