crystallin alpha B (Q21100907)

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mammalian protein found in Homo sapiens
  • heat shock protein beta-5
  • CRYAB
  • heat-shock 20 kD like-protein
  • Alpha(B)-crystallin
  • renal carcinoma antigen NY-REN-27
  • rosenthal fiber component
  • HspB5
  • alpha-crystallin B chain
  • epididymis secretory protein Li 101
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Language Label Description Also known as
English
crystallin alpha B
mammalian protein found in Homo sapiens
  • heat shock protein beta-5
  • CRYAB
  • heat-shock 20 kD like-protein
  • Alpha(B)-crystallin
  • renal carcinoma antigen NY-REN-27
  • rosenthal fiber component
  • HspB5
  • alpha-crystallin B chain
  • epididymis secretory protein Li 101

Statements

molecular function
protein binding
determination method or standard
IPI
18 references
retrieved
8 April 2019
stated in
αB-crystallin is a sensor for assembly intermediates and for the subunit topology of desmin intermediate filaments.
GOA
curator
UniProt
UniProt protein ID
P02511
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Synergistic efficacy of LBH and alphaB-crystallin through inhibiting transcriptional activities of p53 and p21.
GOA
curator
UniProt
UniProt protein ID
P02511
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis
GOA
curator
UniProt
UniProt protein ID
P02511
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
alphaB-crystallin competes with Alzheimer's disease beta-amyloid peptide for peptide-peptide interactions and induces oxidation of Abeta-Met35
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Binding determinants of the small heat shock protein, αB-crystallin: recognition of the 'IxI' motif
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Preferential and Specific Binding of Human αB-Crystallin to a Cataract-Related Variant of γS-Crystallin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
The polydispersity of αB-crystallin is rationalized by an interconverting polyhedral architecture
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
The eye lens chaperone alpha-crystallin forms defined globular assemblies.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Temperature-dependent structural and functional properties of a mutant (F71L) αA-crystallin: molecular basis for early onset of age-related cataract
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Alteration of protein-protein interactions of congenital cataract crystallin mutants
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Detection of protein-protein interactions among lens crystallins in a mammalian two-hybrid system assay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of the C-terminal extensions of alpha-crystallins. Swapping the C-terminal extension of alpha-crystallin to alphaB-crystallin results in enhanced chaperone activity
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
identical protein binding
determination method or standard
IPI
10 references
retrieved
8 April 2019
stated in
N-terminal domain of  B-crystallin provides a conformational switch for multimerization and structural heterogeneity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Binding determinants of the small heat shock protein, αB-crystallin: recognition of the 'IxI' motif
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Preferential and Specific Binding of Human αB-Crystallin to a Cataract-Related Variant of γS-Crystallin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
The polydispersity of αB-crystallin is rationalized by an interconverting polyhedral architecture
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
The eye lens chaperone alpha-crystallin forms defined globular assemblies.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Multiple molecular architectures of the eye lens chaperone  B-crystallin elucidated by a triple hybrid approach
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Alteration of protein-protein interactions of congenital cataract crystallin mutants
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
retrieved
8 April 2019
stated in
Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02511
determination method or standard
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
D038203
subject named as
alpha-Crystallin B Chain
0 references
Ensembl protein ID
PDB structure ID
 
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