A novel transcription factor, T-bet, directs Th1 lineage commitment (Q22253874)

multicellular organism development

GOA release 2020-03-11

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GOA release 2020-03-11

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6

L H

Glimcher

L H Glimcher

1 reference

29 March 2023

S J Szabo

1

S J

Szabo

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29 March 2023

S T Kim

2

S T

Kim

1 reference

29 March 2023

G L Costa

3

G L

Costa

1 reference

29 March 2023

X Zhang

4

X

Zhang

1 reference

29 March 2023

C G Fathman

5

C G

Fathman

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Functional diversity of helper T lymphocytes

29 March 2023

language of work or name

English

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publication date

17 March 2000

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published in

Cell

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volume

100

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issue

6

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page(s)

655-69

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cites work

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Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome

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Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome

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P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin

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IL-2 promoter-driven lacZ expression as a monitoring tool for IL-2 expression in primary T cells of transgenic mice.

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Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells

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Interleukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type 1 cells.

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Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches

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Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles

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GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels

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Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates

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The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

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Structure of the human immune interferon gene

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Cloning of the T gene required in mesoderm formation in the mouse

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The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

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NF-AT-Driven interleukin-4 transcription potentiated by NIP45

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Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette

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Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

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Immune response in mice that lack the interferon-gamma receptor

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Transcriptional Regulation: : Converting an activator into a repressor

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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

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High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

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Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo

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The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells

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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

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Reversibility of T helper 1 and 2 populations is lost after long-term stimulation

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Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor

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The IL-4 receptor: signaling mechanisms and biologic functions

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Cytokines induce the development of functionally heterogeneous T helper cell subsets

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Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

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The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway.

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Lymphocyte responses and cytokines

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The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells

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The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity

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A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors

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Interaction of NF-kappaB and NFAT with the interferon-gamma promoter

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Brachyury and the T-box genes

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The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-gamma promoter in T cells

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Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc

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Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

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Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

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Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds.

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Multistage regulation of Th1-type immune responses by the transcription factor IRF-1

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Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

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Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

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Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

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The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

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Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017