Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis (Q24292477)

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English	Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis	scientific article

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scholarly article

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Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis (English)

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author name string

Caroline Saucier

1

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Vasilios Papavasiliou

2

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Alexander Palazzo

3

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Monica A Naujokas

4

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Richard Kremer

5

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Morag Park

6

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language of work or name

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publication date

14 March 2002

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21

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12

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1800-11

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Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Oncogenic kinase signalling

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Molecular cloning of a new transforming gene from a chemically transformed human cell line.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Distinct Tyrosine Autophosphorylation Sites Negatively and Positively Modulate Neu-Mediated Transformation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cgamma or phosphatidylinositol 3 kinase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Identification of tyrosine 489 in the carboxy terminus of the Tpr-Met oncoprotein as a major site of autophosphorylation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Coupling of the Proto-oncogene Product c-Cbl to the Epidermal Growth Factor Receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Association of the Multisubstrate Docking Protein Gab1 with the Hepatocyte Growth Factor Receptor Requires a Functional Grb2 Binding Site Involving Tyrosine 1356

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Mechanism of met oncogene activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Protein modules and signalling networks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Oncogenic activation of tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Overexpression of phosphoinositide-specific phospholipase Cgamma in NIH 3T3 cells promotes transformation and tumorigenicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

21 January 2018

Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphoinositide-specific phospholipase C and mitogenic signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

7 January 2021

based on heuristic

inferred from DOI database lookup

Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

7 January 2021

based on heuristic

inferred from DOI database lookup

Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205261

7 January 2021

based on heuristic

inferred from DOI database lookup

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