Targeting the RB-E2F pathway in breast cancer (Q28069626)

ubiquitin-protein ligases

28 September 2019

1 reference

retinoblastoma binding proteins

20 November 2019

1 reference

Cyclin dependent kinase 6

28 November 2019

1 reference

10 December 2019

1 reference

22 December 2019

1 reference

U McDermott

3

0 references

René Bernards

object named as

R Bernards

6

0 references

author name string

J Johnson

1

1 reference

B Thijssen

2

1 reference

M Garnett

4

1 reference

L F A Wessels

5

1 reference

language of work or name

1 reference

15 September 2016

11 references

13 March 2019

3 April 2019

17 June 2019

28 September 2019

20 November 2019

28 November 2019

10 December 2019

19 December 2019

22 December 2019

7 February 2024

11 references

13 March 2019

3 April 2019

17 June 2019

28 September 2019

20 November 2019

28 November 2019

10 December 2019

19 December 2019

22 December 2019

7 February 2024

35

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issue

37

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page(s)

4829-35

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Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer Progression

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20 March 2017

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CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors

20 March 2017

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Cyclin-dependent kinase inhibitor therapy for hematologic malignancies

20 March 2017

1 reference

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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

20 March 2017

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PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

20 March 2017

1 reference

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Genes that mediate breast cancer metastasis to the brain

20 March 2017

1 reference

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Cell cycle, CDKs and cancer: a changing paradigm

20 March 2017

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

20 March 2017

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A gene-expression signature as a predictor of survival in breast cancer

20 March 2017

1 reference

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Gene expression profiling predicts clinical outcome of breast cancer

20 March 2017

1 reference

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Cdk2 knockout mice are viable

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Genes that mediate breast cancer metastasis to lung

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

7 April 2017

1 reference

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Oncogenic pathway signatures in human cancers as a guide to targeted therapies

7 April 2017

1 reference

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A multigenic program mediating breast cancer metastasis to bone

7 April 2017

1 reference

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E2f3 in tumor macrophages promotes lung metastasis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Increased metastasis with loss of E2F2 in Myc-driven tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

β-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

E2F4 regulatory program predicts patient survival prognosis in breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Molecular pathways: CDK4 inhibitors for cancer therapy

29 September 2017

1 reference

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HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

The retinoblastoma tumor suppressor pathway modulates the invasiveness of ErbB2-positive breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

REACTIN: regulatory activity inference of transcription factors underlying human diseases with application to breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

The DREAM complex: master coordinator of cell cycle-dependent gene expression.

29 September 2017

1 reference

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CDK4: A Key Player in the Cell Cycle, Development, and Cancer

29 September 2017

1 reference

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The retinoblastoma tumor suppressor and stem cell biology

29 September 2017

1 reference

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Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors

29 September 2017

1 reference

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GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Biological functions of the genes in the mammaprint breast cancer profile reflect the hallmarks of cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Deconstructing the molecular portraits of breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Small molecule regulators of Rb-E2F pathway as modulators of transcription

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

A pathway-based classification of human breast cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Emerging roles of E2Fs in cancer: an exit from cell cycle control

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Lessons in signaling and tumorigenesis from polyomavirus middle T antigen

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Gene set-based module discovery in the breast cancer transcriptome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Gene expression meta-analysis identifies metastatic pathways and transcription factors in breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

CDK9 a potential target for drug development.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

The use of gene-expression profiling to better understand the clinical heterogeneity of estrogen receptor positive breast cancers and tamoxifen response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Predicting the clinical status of human breast cancer by using gene expression profiles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Cdk1 is sufficient to drive the mammalian cell cycle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4950965

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.32

Expression of E2F-4 in invasive breast carcinomas is associated with poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.32

CDK2 is dispensable for adult hippocampal neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.32

Tumor induction and tissue atrophy in mice lacking E2F-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.32

Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.32

Prediction and genetic demonstration of a role for activator E2Fs in Myc-induced tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.32

31 March 2020

Identifiers

DOI

10.1038/ONC.2016.32

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4765554

Dimensions Publication ID

1024091241

0 references

OpenCitations bibliographic resource ID

4765554

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

PubMed publication ID

26923330

1 reference