dabrafenib (Q3011604)

Dabrafenib (English)

19 October 2016

C₂₃H₂₀F₃N₅O₂S₂

1 reference

Dabrafenib (English)

18 November 2016

CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F

1 reference

World Health Organisation international non-proprietary name

Dabrafenib (English)

18 November 2016

1 reference

14 February 2018

dabrafenib (English)

2 references

medical condition treated

dabrafenib (English)

19 October 2016

Recommended INN: List 67

publication date

2012

non-small-cell lung carcinoma

1 reference

2 October 2018

metastatic melanoma

1 reference

2 October 2018

skin cancer

1 reference

2 October 2018

melanoma

1 reference

significant drug interaction

2 October 2018

crizotinib

bone marrow failure

1 reference

A reference set of clinically relevant adverse drug-drug interactions

idelalisib

bone marrow failure

1 reference

A reference set of clinically relevant adverse drug-drug interactions

crizotinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

Ketoconazole

1 reference

A reference set of clinically relevant adverse drug-drug interactions

voriconazole

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ritonavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

clarithromycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fosphenytoin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

physically interacts with

B-Raf proto-oncogene, serine/threonine kinase

subject has role

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

6494

imported from Wikimedia project

17 August 2016

pregnancy category

US pregnancy category D

1 reference

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category E*

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Dabrafenib

last update

28 June 2018

subject has role

protein kinase inhibitors

2 references

5 March 2018

Medical Subject Headings

15 March 2018

1 reference

Medical Subject Headings

15 March 2018

Dabrafenib

0 references

Identifiers

InChI

InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)

1 reference

Dabrafenib (English)

18 November 2016

2 references

Dabrafenib (English)

18 November 2016

ChEBI release 2020-09-01

CAS Registry Number

1195765-45-7

2 references

https://commonchemistry.cas.org/detail?cas_rn=1195765-45-7

dabrafenib (English)

18 November 2016

6 April 2021

1 reference

Dabrafenib (English)

18 November 2016

2 references

Dabrafenib (English)

18 November 2016

Reaxys registry number

19689971

1 reference

dabrafenib (English)

19 October 2016

mapping relation type

2 references

DABRAFENIB (English)

18 November 2016

International Chemical Identifier

InChI

InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)

1 reference

DABRAFENIB (English)

18 November 2016

2 references

inferred from InChIKey

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

1 reference

2 references

DSSTOX compound identifier

0 references

0 references

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.215.965

27 December 2018

ECHA Substance Infocard ID

N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzene-1-sulfonamide (English)

quotation

CAS no.: 1195765-45-7 (English)

100.215.965

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.215.965

27 December 2018

N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzene-1-sulfonamide (English)

quotation

CAS no.: 1195765-45-7 (English)

1 reference

World Health Organisation international non-proprietary name numeric ID

Dabrafenib (English)

publication date

17 November 2015

9458

1 reference

reference URL

https://mednet-communities.net/inn/db/ViewINN.aspx?i=9458

Guide to Pharmacology Ligand ID

6494

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

6494

dabrafenib (English)

18 November 2016

dabrafenib

1 reference

Medical Subject Headings

14 March 2018

1 reference

dabrafenib (English)

18 November 2016

1 reference

Human Metabolome Database ID

HMDB0250818

2 references

based on heuristic

inferred from InChIKey

2 references

dabrafenib (English)

18 November 2016

MedlinePlus drug identifier

a613038

0 references

PatientsLikeMe treatment ID

0 references

1 reference

dabrafenib (English)

18 November 2016

0 references

1 reference

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

dabrafenib (English)

19 October 2016

0 references

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

5CSW (English)

19 October 2016

1 reference

4XV2 (English)

19 October 2016

1 reference

5HIE (English)

19 October 2016

1 reference