integrin subunit beta 1 (Q4201966)

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mammalian protein found in Homo sapiens
  • integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
  • GPIIA
  • very late activation protein, beta polypeptide
  • Fibronectin receptor subunit beta
  • integrin VLA-4 beta subunit
  • integrin beta-1
  • ITGB1
  • integrin beta 1
  • VLA-4 subunit beta
  • glycoprotein IIa
  • Integrin beta1
edit
Language Label Description Also known as
English
integrin subunit beta 1
mammalian protein found in Homo sapiens
  • integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
  • GPIIA
  • very late activation protein, beta polypeptide
  • Fibronectin receptor subunit beta
  • integrin VLA-4 beta subunit
  • integrin beta-1
  • ITGB1
  • integrin beta 1
  • VLA-4 subunit beta
  • glycoprotein IIa
  • Integrin beta1

Statements

molecular function
protein binding
determination method or standard
IPI
43 references
retrieved
8 April 2019
stated in
Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel intracellular fibulin-1D variant binds to the cytoplasmic domain of integrin beta 1 subunit
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
NAG-2, a Novel Transmembrane-4 Superfamily (TM4SF) Protein That Complexes with Integrins and Other TM4SF Proteins
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Effect of medium change on the development of in vitro matured and fertilized bovine oocytes cultured in medium containing amino acids
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
ICAP-1, a Novel β1 Integrin Cytoplasmic Domain–associated Protein, Binds to a Conserved and Functionally Important NPXY Sequence Motif of β1 Integrin
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
CCN3 (NOV) Is a Novel Angiogenic Regulator of the CCN Protein Family
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Basic amino-acid side chains regulate transmembrane integrin signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Epstein-Barr virus infection of polarized tongue and nasopharyngeal epithelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Filamin A regulates cell spreading and survival via beta1 integrins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibition of β1 integrin and IL-3Rβ common subunit interaction hinders tumour angiogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
SHARPIN is an endogenous inhibitor of β1-integrin activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ganglioside GM3 Inhibits Matrix Metalloproteinase-9 Activation and Disrupts Its Association with Integrin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
A family of beta 7 integrins on human mucosal lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural Diversity in Integrin/Talin Interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of dystrophins and utrophins in platelet adhesion process
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of L-plastin interaction with beta integrin and its regulation by micro-calpain
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IPI
cell component
cell surface
determination method or standard
IDA
IEA
17 references
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IEA
retrieved
26 September 2017
stated in
Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
Characterization of integrin engagement during defined human embryonic stem cell culture
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
Quantitative proteomics identifies a Dab2/integrin module regulating cell migration
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
plasma membrane
determination method or standard
NAS
IDA
TAS
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
TAS
retrieved
8 April 2019
stated in
A novel protease-docking function of integrin at invadopodia
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IEA
retrieved
8 April 2019
stated in
JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
Role of dystrophins and utrophins in platelet adhesion process
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
focal adhesion
determination method or standard
IDA
IEA
6 references
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IEA
retrieved
26 September 2017
stated in
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
26 September 2017
stated in
Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IDA
focal adhesion
determination method or standard
HDA
IBA
IDA
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IEA
retrieved
8 April 2019
stated in
Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IBA
retrieved
8 April 2019
stated in
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
HDA
cell surface
determination method or standard
HDA
IBA
IDA
IEA
18 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IEA
retrieved
8 April 2019
stated in
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
Characterization of integrin engagement during defined human embryonic stem cell culture
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IBA
retrieved
8 April 2019
stated in
Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
HDA
retrieved
8 April 2019
stated in
Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
HDA
retrieved
8 April 2019
stated in
Quantitative proteomics identifies a Dab2/integrin module regulating cell migration
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
HDA
retrieved
8 April 2019
stated in
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
HDA
biological process
cell-matrix adhesion
determination method or standard
IEA
IMP
5 references
retrieved
26 September 2017
stated in
CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IMP
retrieved
26 September 2017
stated in
Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IMP
retrieved
26 September 2017
stated in
Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IMP
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05556&geneProductId=UniProtKB:P05556
determination method or standard
IEA
cell-matrix adhesion
determination method or standard
IBA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IMP
retrieved
8 April 2019
stated in
Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner
GOA
curator
UniProt
UniProt protein ID
P05556
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IMP
retrieved
8 April 2019
stated in
Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05556
determination method or standard
IBA

Identifiers

MeSH descriptor ID
D019012
subject named as
Integrin beta1
0 references
Freebase ID
/m/02q6c22
0 references
 
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