5-hydroxytryptamine receptor 2B (Q4639596)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41595

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.3.7

hierarchical database ID heuristic

2 October 2019

based on heuristic

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595

1 reference

1 January 2018

G protein-coupled serotonin receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595

5 references

21 June 2018

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595

21 June 2018

Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595

21 June 2018

The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595

21 June 2018

The pharmacology and distribution of human 5‐hydroxytryptamine2B (5‐HT2b) receptor gene products: comparison with 5‐HT2a and 5‐HT2c receptors

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595

G-protein alpha-subunit binding

1 reference

8 April 2019

The natural mutation encoding a C terminus-truncated 5-hydroxytryptamine 2B receptor is a gain of proliferative functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

serotonin binding

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

The natural mutation encoding a C terminus-truncated 5-hydroxytryptamine 2B receptor is a gain of proliferative functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

Identification of a key amino acid of the human 5-HT(2B) serotonin receptor important for sarpogrelate binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

The pharmacology and distribution of human 5‐hydroxytryptamine2B (5‐HT2b) receptor gene products: comparison with 5‐HT2a and 5‐HT2c receptors

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

neurotransmitter receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

G protein-coupled receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

G protein-coupled serotonin receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

6 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

The pharmacology and distribution of human 5‐hydroxytryptamine2B (5‐HT2b) receptor gene products: comparison with 5‐HT2a and 5‐HT2c receptors

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

The natural mutation encoding a C terminus-truncated 5-hydroxytryptamine 2B receptor is a gain of proliferative functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

1 reference

8 April 2019

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

1 reference

8 April 2019

neuron projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

1 reference

8 April 2019

integral component of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595

1 reference

21 June 2018

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

1 reference

8 April 2019

dendrite

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

intestine smooth muscle contraction

biological process

smooth muscle contraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

1 reference

8 April 2019

G protein-coupled receptor internalization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

release of sequestered calcium ion into cytosol

5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

Characterization of the 5-HT2b receptor in evaluation of aequorin detection of calcium mobilization for miniaturized GPCR high-throughput screening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

regulation of behavior

A population-specific HTR2B stop codon predisposes to severe impulsivity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

positive regulation of endothelial cell proliferation

positive regulation of MAP kinase activity

1 reference

8 April 2019

The natural mutation encoding a C terminus-truncated 5-hydroxytryptamine 2B receptor is a gain of proliferative functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

phosphorylation

1 reference

8 April 2019

Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

positive regulation of cytokine production

1 reference

8 April 2019

Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol biosynthetic process

1 reference

8 April 2019

Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

cellular calcium ion homeostasis

negative regulation of cell death

1 reference

8 April 2019

Serotonin promotes tumor growth in human hepatocellular cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

activation of phospholipase C activity

protein kinase C signaling

1 reference

8 April 2019

Serotonin promotes tumor growth in human hepatocellular cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

cGMP biosynthetic process

1 reference

1 January 2018

Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595

positive regulation of GTPase activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

positive regulation of nitric-oxide synthase activity

1 reference

8 April 2019

The natural mutation encoding a C terminus-truncated 5-hydroxytryptamine 2B receptor is a gain of proliferative functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

serotonin receptor signaling pathway

1 reference

8 April 2019

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

positive regulation of cell population proliferation

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

positive regulation of I-kappaB kinase/NF-kappaB signaling

IEP

1 reference

8 April 2019

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

phosphatidylinositol 3-kinase signaling

IEP

1 reference

8 April 2019

Pharmacological evidence for a functional serotonin-2B receptor in a human uterine smooth muscle cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

negative regulation of autophagy

1 reference

8 April 2019

Serotonin promotes tumor growth in human hepatocellular cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

calcium-mediated signaling

1 reference

8 April 2019

5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

1 reference

8 April 2019

phospholipase C-activating G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595

1 reference

21 June 2018

G protein-coupled serotonin receptor signaling pathway

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

4 references

8 April 2019

TAS

8 April 2019

The natural mutation encoding a C terminus-truncated 5-hydroxytryptamine 2B receptor is a gain of proliferative functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

8 April 2019

animal behaviour

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

1 reference

8 April 2019

cGMP-mediated signaling

1 reference

8 April 2019

Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

chemical synaptic transmission

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595

physically interacts with

lysergic acid diethylamide

1 reference

17

17 August 2016

5-carboxamidotryptamine

1 reference

4

17 August 2016

1 reference

5

(+/-)-8-hydroxy-2-(di-N-propylamino)tetralin

17 August 2016

1 reference

7

17 August 2016

1 reference

160

17 August 2016

1 reference

152

17 August 2016

1 reference

163

17 August 2016

1 reference

161

17 August 2016

1 reference

37

17 August 2016

1 reference

109

4-iodo-2,5-dimethoxyphenylisopropylamine

17 August 2016

1 reference

147

17 August 2016

1 reference

2941

17 August 2016

1 reference

165

17 August 2016

1 reference

215

17 August 2016

1 reference

170

17 August 2016

1 reference

171

17 August 2016

1 reference

48

17 August 2016

1 reference

91

17 August 2016

1 reference

2

17 August 2016

1 reference

173

17 August 2016

1 reference

23

1-(3-trifluoromethylphenyl)piperazine

17 August 2016

1 reference

115

17 August 2016

1 reference

125

17 August 2016

1 reference

168

17 August 2016

1 reference

10

17 August 2016

1 reference

149

17 August 2016

1 reference

14

17 August 2016

m-chlorophenylpiperazine

1 reference

142

17 August 2016

1 reference

150

17 August 2016

1 reference

134

17 August 2016

1 reference

28

17 August 2016

1 reference

3

17 August 2016

1 reference

198

17 August 2016

1 reference

33

17 August 2016

1 reference

35

17 August 2016

1 reference

38

17 August 2016

1 reference

203

17 August 2016

1 reference

186

17 August 2016

1 reference

86

17 August 2016

1 reference

88

17 August 2016

1 reference

177

17 August 2016

1 reference

43

17 August 2016

1 reference

224

17 August 2016

1 reference

206

17 August 2016

1 reference

133

17 August 2016

1 reference

89

17 August 2016

1 reference

135

17 August 2016

1 reference

208

17 August 2016

1 reference

225

17 August 2016

1 reference

49

17 August 2016

1 reference

136

17 August 2016

1 reference

97

17 August 2016

1 reference

52

17 August 2016

1 reference

187

17 August 2016

1 reference

188

17 August 2016

1 reference

210

17 August 2016

1 reference

221

17 August 2016

1 reference

189

17 August 2016

1 reference

193

17 August 2016

1 reference

194

17 August 2016

1 reference

143

17 August 2016

1 reference

195

17 August 2016

1 reference

99

17 August 2016

1 reference

175

17 August 2016

1 reference

53

17 August 2016

1 reference

56

17 August 2016

1 reference

213

17 August 2016

1 reference

185

17 August 2016

1 reference

57

17 August 2016

1 reference

102

object of statement has role

17 August 2016

zimeldine

antagonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL37744

Gene Atlas image

PBB GE HTR2B 206638 at fs.png
732 × 530; 11 KB

0 references

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41595

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

0 references

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

9.A.14.3.7

2 references

Transporter Classification database

13 March 2020

Transporter Classification database