cobicistat (Q5138908)

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chemical compound

GS-9350
GS 9350
Cobicistat
1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate

Language	Label	Description	Also known as
English	cobicistat	chemical compound	GS-9350 GS 9350 Cobicistat 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate

Statements

type of chemical entity

0 references

1,3-thiazol-5-ylmethyl N-[5-[[2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate

1 reference

based on heuristic

inferred from InChIKey

0 references

chemical structure

Cobicistat.svg
512 × 230; 51 KB

0 references

775.35496 dalton

1 reference

language of work or name

Cobicistat (English)

3 October 2016

chemical formula

C₄₀H₅₃N₇O₅S₂

1 reference

language of work or name

Cobicistat (English)

19 November 2016

canonical SMILES

CC(C)C1=NC(=CS1)CN(C)C(=O)NC(CCN2CCOCC2)C(=O)NC(CCC(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5

1 reference

language of work or name

Cobicistat (English)

19 November 2016

isomeric SMILES

CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5

1 reference

language of work or name

Cobicistat (English)

19 November 2016

defined daily dose

0.15 gram

route of administration

oral administration

1 reference

https://www.whocc.no/atc_ddd_index/?code=V03AX03

active ingredient in

1 reference

14 February 2018

World Health Organisation international non-proprietary name

cobicistat (English)

1 reference

language of work or name

cobicistat (English)

3 October 2016

significant drug interaction

long QT syndrome

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

central respiratory depression

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

visual impairment

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

sinus bradycardia

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

acute kidney injury

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

muscular disease

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

muscular disease

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

central respiratory depression

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

long QT syndrome

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

torsades de pointes

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

long QT syndrome

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

pulseless electrical activity

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

1 reference

sourcing circumstances

A reference set of clinically relevant adverse drug-drug interactions

subject has role

xenobiotic-transporting ATPase inhibitor

1 reference

5 March 2018

cytochrome P-450 CYP3A inhibitors

1 reference

Medical Subject Headings

MeSH descriptor ID

15 March 2018

anti-HIV agents

1 reference

Medical Subject Headings

MeSH descriptor ID

15 March 2018

Commons category

Cobicistat

0 references

CAS COVID-19 Anti-Viral Candidate Compounds

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Identifiers

InChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32-,33-,36+/m1/s1

1 reference

language of work or name

Cobicistat (English)

19 November 2016

ZCIGNRJZKPOIKD-CQXVEOKZSA-N

2 references

language of work or name

Cobicistat (English)

19 November 2016

ChEBI release 2020-09-01

CAS Registry Number

2 references

Global Substance Registration System

language of work or name

cobicistat (English)

19 November 2016

ZCIGNRJZKPOIKD-CQXVEOKZSA-N

CAS Common Chemistry

9 April 2021

https://commonchemistry.cas.org/detail?cas_rn=1004316-88-4

1 reference

language of work or name

Cobicistat (English)

19 November 2016

2 references

language of work or name

Cobicistat (English)

19 November 2016

matched by identifier from

ZCIGNRJZKPOIKD-CQXVEOKZSA-N

Reaxys registry number

13088386

1 reference

language of work or name

cobicistat (English)

3 October 2016

mapping relation type

2 references

language of work or name

COBICISTAT (English)

19 November 2016

matched by identifier from

International Chemical Identifier

InChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32-,33-,36+/m1/s1

1 reference

language of work or name

COBICISTAT (English)

19 November 2016

2 references

based on heuristic

inferred from InChIKey

matched by identifier from

ZCIGNRJZKPOIKD-CQXVEOKZSA-N

UniChem compound ID

1 reference

DSSTox substance ID

2 references

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

matched by identifier from

ZCIGNRJZKPOIKD-CQXVEOKZSA-N

DSSTOX compound identifier

0 references

1 reference

language of work or name

Cobicistat (English)

publication date

17 November 2015

Guide to Pharmacology Ligand ID

2 references

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

cobicistat (English)

19 November 2016

22 April 2020

https://www.guidetopharmacology.org/coronavirus.jsp

MeSH descriptor ID

subject named as

Cobicistat

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D02.241.081.251.203

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D02.886.675.182

0 references

D03.383.129.708.189

0 references

1 reference

Global Substance Registration System

language of work or name

cobicistat (English)

19 November 2016

1 reference

matched by identifier from

ZCIGNRJZKPOIKD-CQXVEOKZSA-N

2 references

Global Substance Registration System

language of work or name

cobicistat (English)

19 November 2016

matched by identifier from

ZCIGNRJZKPOIKD-CQXVEOKZSA-N

MedlinePlus drug identifier

0 references

1 reference

Global Substance Registration System

language of work or name

cobicistat (English)

19 November 2016

Probes And Drugs ID

0 references

1 reference

1 reference

language of work or name

Cobicistat (English)

19 January 2016

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

Global Substance Registration System

language of work or name

cobicistat (English)

19 November 2016

WikiProjectMed ID

0 references

Sitelinks

Wikipedia(17 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(1 entry)

commonswiki Category:Cobicistat

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