Follicle stimulating hormone receptor (Q5464652)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23945

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.1.5

2 October 2019

hierarchical database ID heuristic

Leucine-rich repeat N-terminal domain, protein family

1 reference

Gonadotropin hormone receptor, transmembrane domain, protein family

1 reference

GPCR, rhodopsin-like, 7TM, protein family

1 reference

BspA type Leucine rich repeat region, protein family

1 reference

G protein-coupled peptide receptor activity

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

1 reference

31 October 2017

protein-hormone receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

1 reference

8 April 2019

protein binding

3 references

8 April 2019

Emerging roles for the FSH receptor adapter protein APPL1 and overlap of a putative 14-3-3τ interaction domain with a canonical G-protein interaction site

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

8 April 2019

Human follitropin receptor (FSHR) interacts with the adapter protein 14-3-3tau

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

8 April 2019

APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex

GOA

curator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

follicle-stimulating hormone receptor activity

Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

31 October 2017

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

31 October 2017

follicle-stimulating hormone receptor activity

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

5 June 2018

5 June 2018

Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

follicle-stimulating hormone receptor activity

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

8 April 2019

8 April 2019

Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

integral component of membrane

cell component

Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

31 October 2017

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

1 reference

8 April 2019

integral component of plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

8 April 2019

8 April 2019

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

intracellular anatomical structure

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

integral component of membrane

Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

8 April 2019

8 April 2019

Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

receptor complex

1 reference

8 April 2019

Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

G protein-coupled receptor signaling pathway

biological process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

4 references

31 October 2017

31 October 2017

Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

31 October 2017

male gonad development

IEP

1 reference

8 April 2019

Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

adenylate cyclase-activating G protein-coupled receptor signaling pathway

IEP

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

female gamete generation

1 reference

8 April 2019

Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

primary ovarian follicle growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

1 reference

5 June 2018

regulation of protein kinase A signaling

1 reference

8 April 2019

Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

female gonad development

1 reference

8 April 2019

Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

activation of adenylate cyclase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

regulation of osteoclast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

1 reference

5 June 2018

spermatogenesis

1 reference

8 April 2019

Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

hormone-mediated signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

gonad development

1 reference

8 April 2019

Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

1 reference

8 April 2019

positive regulation of adenylate cyclase activity

1 reference

10 September 2018

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

cellular response to follicle-stimulating hormone stimulus

1 reference

8 April 2019

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

follicle-stimulating hormone signaling pathway

1 reference

31 October 2017

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23945&geneProductId=UniProtKB:P23945

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

8 April 2019

8 April 2019

Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23945

follicle-stimulating hormone signaling pathway

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

1157

English

http://purl.uniprot.org/uniprot/P23945

17 August 2016

Gene Atlas image

PBB GE FSHR 211201 at fs.png
732 × 530; 12 KB

0 references

exact match

1 reference

Identifiers.org

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

9.A.14.1.5

2 references

Transporter Classification database

13 March 2020

Transporter Classification database