Hypoxia inducible factor 1 subunit alpha (Q5629645)

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mammalian protein found in Homo sapiens
  • HIF1A
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • hypoxia-inducible factor 1-alpha
  • ARNT interacting protein
  • member of PAS protein 1
  • hypoxia-inducible factor1alpha
  • basic-helix-loop-helix-PAS protein MOP1
  • PAS domain-containing protein 8
  • class E basic helix-loop-helix protein 78
  • hypoxia-inducible factor 1 alpha isoform I.3
  • hypoxia inducible factor 1 alpha subunit
  • ARNT-interacting protein
  • bHLHe78
  • member of PAS superfamily 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
edit
Language Label Description Also known as
English
Hypoxia inducible factor 1 subunit alpha
mammalian protein found in Homo sapiens
  • HIF1A
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • hypoxia-inducible factor 1-alpha
  • ARNT interacting protein
  • member of PAS protein 1
  • hypoxia-inducible factor1alpha
  • basic-helix-loop-helix-PAS protein MOP1
  • PAS domain-containing protein 8
  • class E basic helix-loop-helix protein 78
  • hypoxia-inducible factor 1 alpha isoform I.3
  • hypoxia inducible factor 1 alpha subunit
  • ARNT-interacting protein
  • bHLHe78
  • member of PAS superfamily 1
  • Hypoxia-Inducible Factor 1, alpha Subunit

Statements

molecular function
DNA-binding transcription factor activity
determination method or standard
IDA
TAS
IEA
6 references
retrieved
8 April 2019
stated in
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
8 April 2019
stated in
Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Fructose-1,6-bisphosphatase opposes renal carcinoma progression
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
protein binding
determination method or standard
IPI
54 references
retrieved
8 April 2019
stated in
Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
In silico structural and functional characterization of the RSUME splice variants
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of the VHL/HIF-1 pathway by DJ-1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Fructose-1,6-bisphosphatase opposes renal carcinoma progression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
MSF-A interacts with hypoxia-inducible factor-1alpha and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
EAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Androgen-dependent gene expression of prostate-specific antigen is enhanced synergistically by hypoxia in human prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
retrieved
8 April 2019
stated in
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IPI
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method or standard
IDA
IEA
ISA
ISM
NAS
5 references
retrieved
5 June 2018
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
NAS
retrieved
5 June 2018
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
ISM
retrieved
5 June 2018
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
ISA
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
5 June 2018
stated in
Fructose-1,6-bisphosphatase opposes renal carcinoma progression
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IDA
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method or standard
IBA
IEA
ISA
ISM
NAS
5 references
retrieved
10 September 2018
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
NAS
retrieved
10 September 2018
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
ISM
retrieved
10 September 2018
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
ISA
retrieved
10 September 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IBA
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method or standard
IBA
IDA
IEA
ISA
ISM
NAS
9 references
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
NAS
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
ISM
retrieved
8 April 2019
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
ISA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
8 April 2019
stated in
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IBA
cell component
nucleus
determination method or standard
IDA
IEA
11 references
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
16 July 2018
stated in
Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
16 July 2018
stated in
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
16 July 2018
stated in
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
16 July 2018
stated in
Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
16 July 2018
stated in
Fructose-1,6-bisphosphatase opposes renal carcinoma progression
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
16 July 2018
stated in
Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
16 July 2018
stated in
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
16 July 2018
stated in
Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665
determination method or standard
IDA
nucleus
determination method or standard
IBA
IDA
IEA
12 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
8 April 2019
stated in
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Fructose-1,6-bisphosphatase opposes renal carcinoma progression
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IBA
biological process
response to hypoxia
determination method or standard
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
Cellular response to hypoxia involves signaling via Smad proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
8 April 2019
stated in
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
cellular response to hypoxia
determination method or standard
IEA
IDA
IEP
6 references
retrieved
8 April 2019
stated in
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IEP
retrieved
8 April 2019
stated in
Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IEP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
8 April 2019
stated in
Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
positive regulation of gene expression
determination method or standard
IDA
IEA
IMP
5 references
retrieved
8 April 2019
stated in
miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IMP
retrieved
8 April 2019
stated in
MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
8 April 2019
stated in
ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
positive regulation of transcription by RNA polymerase II
determination method or standard
IBA
IDA
IEA
IGI
5 references
retrieved
8 April 2019
stated in
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IGI
retrieved
8 April 2019
stated in
The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IEA
retrieved
8 April 2019
stated in
Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha
GOA
curator
UniProt
UniProt protein ID
Q16665
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665
determination method or standard
IBA

Identifiers

NALT ID
215149
0 references
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q5629645&oldid=2022908186"