The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein (Q59798803)

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scientific article published on 30 November 2018

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English	The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein	scientific article published on 30 November 2018

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scholarly article

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14 April 2020

The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein (English)

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14 April 2020

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renal cell carcinoma

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Margreet Vissers

2

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Margreet C M Vissers

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14 April 2020

Elisabeth Phillips

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Elisabeth Phillips

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14 April 2020

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Helen Morrin

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14 April 2020

Bridget Robinson

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Bridget A Robinson

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14 April 2020

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Gabi U Dachs

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14 April 2020

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Christina Wohlrab

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14 April 2020

publication date

30 November 2018

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14 April 2020

Frontiers in Oncology

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14 April 2020

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14 April 2020

574

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14 April 2020

copyright license

Creative Commons Attribution 4.0 International

30 November 2018

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April 2022 Public Data File from Crossref

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6284050/fullTextXML

based on heuristic

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Diet, obesity and risk for renal cell carcinoma: results from a case control-study in Germany

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

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Diet and risk of renal cell cancer: a population-based case-control study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cruciferous vegetables in relation to renal cell carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

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Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of dietary, medical and lifestyle risk factors for incident kidney cancer in postmenopausal women.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different isoform patterns for vascular endothelial growth factor between clear cell and papillary renal cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival analysis of 130 patients with papillary renal cell carcinoma: prognostic utility of type 1 and type 2 subclassification

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renal cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

State of the science: an update on renal cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ascorbic acid: chemistry, biology and the treatment of cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passing the baton: the HIF switch

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NIH Image to ImageJ: 25 years of image analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human sodium-dependent ascorbic acid transporters SLC23A1 and SLC23A2 do not mediate ascorbic acid release in the proximal renal epithelial cell.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Review of high-dose intravenous vitamin C as an anticancer agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor VEGF expression correlates with tumor stage and identifies prognostically different groups in patients with clear cell renal cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A clearer view of the molecular complexity of clear cell renal cell carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

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inferred from PubMed ID database lookup

International variations and trends in renal cell carcinoma incidence and mortality.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

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New strategies in renal cell carcinoma: targeting the genetic and metabolic basis of disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

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Beyond evidence-based data: scientific rationale and tumor behavior to drive sequential and personalized therapeutic strategies for the treatment of metastatic renal cell carcinoma

1 reference

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Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

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based on heuristic

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Ascorbic acid, but not dehydroascorbic acid increases intracellular vitamin C content to decrease Hypoxia Inducible Factor -1 alpha activity and reduce malignant potential in human melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporo-spacial microanatomical distribution of the murine sodium-dependent ascorbic acid transporters Slc23a1 and Slc23a2 in the kidney throughout development

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

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inferred from PubMed ID database lookup

Survival of metastatic renal cell carcinoma patients continues to improve over time, even in targeted therapy era.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

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based on heuristic

inferred from PubMed ID database lookup

Expression of hypoxia inducible factor 1α and 2α and its association with vitamin C level in thyroid lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

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based on heuristic

inferred from PubMed ID database lookup

Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/30555801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3389/FONC.2018.00574

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30555801%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30555801%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30555801%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

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