Growth differentiation factor 15 (Q74581)

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mammalian protein found in Homo sapiens

• placental TGF-beta
• prostate differentiation factor
• NRG-1
• GDF15
• MIC-1
• NAG-1
• PTGF-beta
• NSAID-regulated gene 1 protein
• macrophage inhibitory cytokine 1
• placental bone morphogenetic protein
• non-steroidal anti-inflammatory drug-activated gene-1
• NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1
• growth/differentiation factor 15
• NSAID-activated gene 1 protein

edit

Language	Label	Description	Also known as
English	Growth differentiation factor 15	mammalian protein found in Homo sapiens	placental TGF-beta prostate differentiation factor NRG-1 GDF15 MIC-1 NAG-1 PTGF-beta NSAID-regulated gene 1 protein macrophage inhibitory cytokine 1 placental bone morphogenetic protein non-steroidal anti-inflammatory drug-activated gene-1 NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1 growth/differentiation factor 15 NSAID-activated gene 1 protein

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q99988

part of

Transforming growth factor-beta-related

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99988

Cystine-knot cytokine

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99988

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

GDF15.png
1,920 × 975; 387 KB

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q99988

encoded by

GDF15

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q99988

molecular function

transforming growth factor beta receptor binding

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IBA

growth factor activity

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IEA

protein binding

determination method or standard

IPI

5 references

retrieved

8 April 2019

stated in

NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IPI

retrieved

8 April 2019

stated in

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IPI

retrieved

8 April 2019

stated in

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IPI

retrieved

8 April 2019

stated in

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IPI

retrieved

8 April 2019

stated in

An empirical framework for binary interactome mapping

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IPI

cytokine activity

determination method or standard

IBA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IBA

protein homodimerization activity

determination method or standard

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IEA

retrieved

8 April 2019

stated in

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

cell component

extracellular region

determination method or standard

TAS

IEA

2 references

retrieved

17 October 2017

stated in

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99988&geneProductId=UniProtKB:Q99988

determination method or standard

TAS

retrieved

17 October 2017

stated in

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99988&geneProductId=UniProtKB:Q99988

determination method or standard

IEA

extracellular exosome

determination method or standard

IDA

2 references

retrieved

17 October 2017

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99988&geneProductId=UniProtKB:Q99988

determination method or standard

IDA

retrieved

17 October 2017

stated in

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99988&geneProductId=UniProtKB:Q99988

determination method or standard

IDA

nucleus

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

cytoplasm

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

extracellular space

determination method or standard

IDA

IEA

2 references

retrieved

17 October 2017

stated in

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99988&geneProductId=UniProtKB:Q99988

determination method or standard

IEA

retrieved

17 October 2017

stated in

NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99988&geneProductId=UniProtKB:Q99988

determination method or standard

IDA

extracellular region

determination method or standard

IDA

IEA

TAS

5 references

retrieved

8 April 2019

stated in

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IEA

retrieved

8 April 2019

stated in

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

retrieved

8 April 2019

stated in

GDF15 is a heart-derived hormone that regulates body growth

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

extracellular space

determination method or standard

IBA

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IEA

retrieved

8 April 2019

stated in

NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IBA

Golgi apparatus

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

collagen-containing extracellular matrix

determination method or standard

HDA

1 reference

retrieved

8 April 2019

stated in

Comprehensive proteomic characterization of stem cell-derived extracellular matrices

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

HDA

extracellular exosome

determination method or standard

HDA

1 reference

retrieved

8 April 2019

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

HDA

biological process

regulation of apoptotic process

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IBA

cell-cell signaling

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

TAS

positive regulation of pathway-restricted SMAD protein phosphorylation

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IBA

positive regulation of myoblast fusion

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IEA

regulation of MAPK cascade

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IBA

transforming growth factor beta receptor signaling pathway

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Human cDNA encoding a novel TGF-beta superfamily protein highly expressed in placenta

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

TAS

cell development

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IBA

signal transduction

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

TAS

BMP signaling pathway

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IBA

SMAD protein signal transduction

determination method or standard

IDA

1 reference

retrieved

17 October 2017

stated in

NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99988&geneProductId=UniProtKB:Q99988

determination method or standard

IDA

regulation of signaling receptor activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IEA

reduction of food intake in response to dietary excess

determination method or standard

IDA

IEA

6 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IEA

retrieved

8 April 2019

stated in

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

retrieved

8 April 2019

stated in

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

retrieved

8 April 2019

stated in

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

retrieved

8 April 2019

stated in

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

retrieved

8 April 2019

stated in

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

glial cell-derived neurotrophic factor receptor signaling pathway

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

negative regulation of multicellular organism growth

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IEA

positive regulation of MAPK cascade

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IMP

positive regulation of protein kinase B signaling

determination method or standard

IDA

IMP

2 references

retrieved

8 April 2019

stated in

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IMP

retrieved

8 April 2019

stated in

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

SMAD protein signal transduction

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IBA

negative regulation of growth hormone receptor signaling pathway

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q99988

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988

determination method or standard

IEA

Gene Atlas image

PBB GE GDF15 221577 x at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/Q99988

1 reference

stated in

Identifiers.org

has part(s)

Transforming growth factor-beta, C-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99988

Identifiers

MeSH descriptor ID

D055436

subject named as

Growth Differentiation Factor 15

0 references

MeSH tree code

D12.644.276.374.305

0 references

D12.644.276.954.300.915

0 references

D12.776.467.374.305

0 references

D12.776.467.942.300.915

0 references

D23.529.374.305

0 references

D23.529.942.300.915

0 references

RefSeq protein ID

NP_004855

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9518

XP_024307557

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9518

UniProt protein ID

Q99988

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q99988

Ensembl protein ID

ENSP00000252809

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000252809

ENSP00000469819

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000469819

ENSP00000470531

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000470531

PDB structure ID

5VT2

found in taxon

Homo sapiens

0 references

5VZ3

found in taxon

Homo sapiens

0 references

5VZ4

found in taxon

Homo sapiens

0 references

6Q2J

found in taxon

Homo sapiens

0 references

UMLS CUI

C0668195

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q74581&oldid=2022900504"