Zona pellucida glycoprotein 3 (Q8063257)

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mammalian protein found in Homo sapiens

Zp-3
ZP3
zona pellucida protein C
ZP3A/ZP3B
sperm receptor
zona pellucida glycoprotein 3B
zona pellucida sperm-binding protein 3
zona pellucida glycoprotein ZP3

Language	Label	Description	Also known as
English	Zona pellucida glycoprotein 3	mammalian protein found in Homo sapiens	Zp-3 ZP3 zona pellucida protein C ZP3A/ZP3B sperm receptor zona pellucida glycoprotein 3B zona pellucida sperm-binding protein 3 zona pellucida glycoprotein ZP3

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

acrosin binding

determination method or standard

1 reference

24 April 2018

Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21754&geneProductId=UniProtKB:P21754

determination method or standard

protein binding

determination method or standard

3 references

8 April 2019

Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

8 April 2019

A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

8 April 2019

Identification of sperm head proteins involved in zona pellucida binding

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

carbohydrate binding

determination method or standard

1 reference

8 April 2019

Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

identical protein binding

determination method or standard

1 reference

8 April 2019

A common 'aggregation-prone' interface possibly participates in the self-assembly of human zona pellucida proteins.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

receptor ligand activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

extracellular matrix structural constituent

determination method or standard

1 reference

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

acrosin binding

determination method or standard

structural constituent of egg coat

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

extracellular matrix structural constituent

determination method or standard

integral component of membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

extracellular matrix

determination method or standard

1 reference

24 April 2018

Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21754&geneProductId=UniProtKB:P21754

determination method or standard

extracellular space

determination method or standard

1 reference

8 April 2019

Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21754&geneProductId=UniProtKB:P21754

determination method or standard

extracellular matrix

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21754&geneProductId=UniProtKB:P21754

determination method or standard

collagen-containing extracellular matrix

determination method or standard

biological process

positive regulation of inflammatory response

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

positive regulation of leukocyte migration

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

positive regulation of phosphatidylinositol biosynthetic process

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

positive regulation of antral ovarian follicle growth

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

positive regulation of interferon-gamma production

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

blastocyst formation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

positive regulation of interleukin-4 production

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

oocyte development

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

positive regulation of type IV hypersensitivity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

humoral immune response mediated by circulating immunoglobulin

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

positive regulation of acrosome reaction

determination method or standard

3 references

24 April 2018

Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21754&geneProductId=UniProtKB:P21754

determination method or standard

24 April 2018

A role for the human sperm glycine receptor/Cl(-) channel in the acrosome reaction initiated by recombinant ZP3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21754&geneProductId=UniProtKB:P21754

determination method or standard

24 April 2018

Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21754&geneProductId=UniProtKB:P21754

determination method or standard

positive regulation of humoral immune response

determination method or standard

1 reference

8 April 2019

DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

positive regulation of T cell proliferation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

binding of sperm to zona pellucida

determination method or standard

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21754&geneProductId=UniProtKB:P21754

determination method or standard

24 April 2018

DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21754&geneProductId=UniProtKB:P21754

determination method or standard

24 April 2018

Human ZP3 restores fertility in Zp3 null mice without affecting order-specific sperm binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21754&geneProductId=UniProtKB:P21754

determination method or standard

24 April 2018

Binding characteristics of sperm with recombinant human zona pellucida glycoprotein-3 coated beads

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21754&geneProductId=UniProtKB:P21754

determination method or standard

24 April 2018

Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21754&geneProductId=UniProtKB:P21754

determination method or standard

negative regulation of binding of sperm to zona pellucida

determination method or standard

1 reference

8 April 2019

Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

positive regulation of ovarian follicle development

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

positive regulation of acrosomal vesicle exocytosis

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

phosphatidylinositol-mediated signaling

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

single fertilization

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

regulation of signaling receptor activity

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

binding of sperm to zona pellucida

determination method or standard

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

8 April 2019

DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

8 April 2019

Human ZP3 restores fertility in Zp3 null mice without affecting order-specific sperm binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

8 April 2019

Binding characteristics of sperm with recombinant human zona pellucida glycoprotein-3 coated beads

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

8 April 2019

Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

egg coat formation

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

positive regulation of acrosome reaction

determination method or standard

4 references

8 April 2019

Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

8 April 2019

Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

8 April 2019

A role for the human sperm glycine receptor/Cl(-) channel in the acrosome reaction initiated by recombinant ZP3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21754

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000337310

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000337310

ENSP00000378326

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378326

ENSP00000378329

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378329

ENSP00000411955

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411955

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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