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Says Welsh, "We've shown that if you give [a chemical analog of 1,25-D] to an animal that already has a mammary tumor, that tumor will regress." Other researchers, she notes, have used 1,25-D analogs to inhibit the spread of cancer or the growth of blood vessels that feed new tumors in laboratory animals.
Feldman's group has shown that giving men 1,25-D analogs for 2 years can reduce the buildup in blood of a protein marker of cancer--prostate-specific antigen (PSA).
Tenofovir naturally substitutes for other nucleoside analogs, not for protease inhibitors or NNRTIs.
Moreover, until recently, no known analogs of nicotine had proved nearly as potent as the original compound.