it is a YMCA reference - that’s one of the 6 memes being represented here
ok let me see if i can break this down easily. YMCA is the easiest place to start - the song itself has become a meme over time with people changing the lyrics to reference other pop cultural events. so YMCA is meme one (1)
this first lyric replacement (”take the breadsticks and run”) is a reference to the tumblr meme ‘stuffing breadsticks into my purse’. i think everyone remembers that one so i wont bother to explain it. that’s meme two (2)
“man door hand hook car door” is a meme of its own, a creepypasta from i dont remember when. it was a terrible stupid retelling of the generic ‘stuck in a car while hook handed man tries to kill us’ story so the stupid title caught on for memorability. that in and of itself is meme three (3)
‘gun’ is… yeah i dont know how to explain gun. long story short you add gun to the end of a phrase instead of what you expect the last word to be. its shock funny. its everywhere but its popular to add to “man door hand hook car door” for.. some reason? gun is meme four (4)
and the thing is, this four meme combo is something thats gone around before. meme combos are, itself, a meme. which means taking this meme combo and mixing in another meme actually becomes meme five (5)
which leaves us at loss.jpg. loss.jpg was a terrible bad comic supposed to be about some tragic event, but it was presented so poorly literally no one takes it seriously, and for some reason recreating the four-panel setup has become popular. so thats meme six (6)
(but i need to add that this is the greatest version of loss.jpg i think i’ve ever seen. the initial ‘young man’ lines up with the guy bursting through the door, and the shock meme ‘gun’ matches the shock scene of the woman in the hospital and idk if OP even thought about that but it makes this just so much better)
