This is barely an exaggeration

*Scrolls past*

*reluctant sigh*

*scrolls back up*

*rebogs*

I still think this tech has the potential to be helpful in a conservation context.... but it says a A LOT that these "dire wolves" look far more like something you'd see in Game of Thrones than any of the most likely reconstructions proposed by scientists who've studied the fossil record.

These pups might get more robust as they age, but right now I'm not seeing anything to get excited about. I just can't help but suspect that this species was chosen specifically bc the public already has the idea of "dire wolf = gray wolf + big", and that this company is using relatively minor CRISPR editing to give the false impression that they're recreating anything that might have conceivably lived 10,000 years ago.

Again, I think this tech is interesting and merits further development (and if jurassic park is the only way they can do that, then, I guess that's what's happening), but it's still extremely misleading to parade these animals around like they've actually 100% cloned a dire wolf.

Really reminds me of Jurassic Park. In the books, Crichton made it very clear that they didn't actually clone dinosaurs. They just combined DNA to make an animal that looked like what people EXPECT a dinosaur to look like, because it turned out that actual cloned dinosaurs were really quite dull and spent most of their time hiding.

Aencyon dirus isn't closely related to modern wolves at all either so it doesn't make any sense to start with a gray wolf. (According to wikipedia they were isolated from the gray wolf lineage for over 5 million years.) we thought they were in genus Canis but turns out it was just convergent evolution and they are a whole other thing

now that I actually read the article, I realize that the lede was buried-- they genetically modified this wolf, and they also cloned 4 critically endangered red wolves

I think the TIME article is really irresponsible in acting like the pups are dire wolves when they don't contain any dire wolf DNA. The "dire wolf" pups are literally just gray wolve engineered to look more like the creatures on Game of Thrones (literally--one of the pups is named Khaleesi)

I remain cautiously optimistic though, because it seems like they are doing actually useful research for preserving existing animals and then putting a Jurassic Park type spin on it for the media.

The Dire wolf thing honestly might just be an attention-grabber to get money off of people that know nothing about ecosystems, and the red wolf might be the actual real purpose of the research. If they've figured out the genetic basis of body size and certain "wolfy" behaviors in wolves, they could make it possible to bring coyote-red wolf hybrids into the red wolf breeding pool without sacrificing the wolf traits

Y'all, just think about guys like Elon Musk. Rich tech bros with a 5 yr old boy's idea of what is cool. This stuff is perfectly calibrated to siphon off some of those techbro's billions, while on the side, being helpful to conservation

Just look at the traits of the altered pups that are highlighted in the article: snout, jaw and limb thickness and heaviness, vocalizations, body size. All key traits that separate red wolves and coyotes.

Here's what the article says:

Recently, Bridgett vonHoldt, a Colossal scientific adviser and an associate professor of ecology and evolutionary biology at Princeton University, and Kristin Brzeski, an associate professor of wildlife science and conservation at Michigan Tech, discovered populations of canids along the coasts of Louisiana and Texas whose DNA included both coyote genes and red wolf ghost alleles. The four red wolves the Colossal scientists created used that natural genetic reservoir to produce what they call the first Ghost Wolf, with an eye to eventually fortifying the red wolf species with more such young carrying a variety of genes.

They're using this technology to bring genetic diversity from red wolf/coyote hybrids back into the red wolf gene pool. As soon as I read "red wolves" I suspected this might be what was happening, and I was right. This could help fix the genetic bottleneck in red wolves and make a real chance for the species to actually return.

this approach is honestly genius

If that is what is happening, good for them! Reminds me of the urban legend about the oceanographers who love to study Loch Ness because it's so very deep that the lower reaches behave like the deep ocean, but you can do your studying from a little motorboat and go home at night. So every time they need money, somebody reports that they saw Nessie again.

If they're just scamming, well... at least they aren't trying to sell us trucks that halt and catch fire...?

@apprenticenerd