DPYS

DPYS
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2VR2
Identifikatori
Aliasi	DPYS
Vanjski ID-jevi	OMIM: 613326 MGI: 1928679 HomoloGene: 20359 GeneCards: DPYS
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	104,467,055 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	39,720,866 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• amino acid binding; • vezivanje iona cinka; • vezivanje iona metala; • dihydropyrimidinase activity; • phosphoprotein binding; • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; • thymine binding; • uracil binding; • hydrolase activity;
Ćelijska komponenta	• citoplazma; • citosol; • Egzosom;
Biološki proces	• beta-alanine metabolic process; • uracil catabolic process; • pyrimidine nucleoside catabolic process; • uracil metabolic process; • pyrimidine nucleobase catabolic process; • protein homooligomerization; • protein homotetramerization; • thymine catabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	1807
	64705
	ENSG00000147647
	ENSMUSG00000022304
	Q14117
	Q9EQF5
	NM_001385
	NM_001164466; NM_022722
	NP_001376
	NP_001157938; NP_073559
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Dihidropirimidinaza je enzim koji je kod ljudi kodiran genom DPYS.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 519 aminokiselina, а molekulska težina 56.630 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAAPSRLLIR	GGRVVNDDFS	EVADVLVEDG	VVRALGHDLL	PPGGAPAGLR
VLDAAGKLVL	PGGIDTHTHM	QFPFMGSRSI	DDFHQGTKAA	LSGGTTMIID
FAIPQKGGSL	IEAFETWRSW	ADPKVCCDYS	LHVAVTWWSD	QVKEEMKILV
QDKGVNSFKM	FMAYKDLYMV	TDLELYEAFS	RCKEIGAIAQ	VHAENGDLIA
EGAKKMLALG	ITGPEGHELC	RPEAVEAEAT	LRAITIASAV	NCPLYIVHVM
SKSAAKVIAD	ARRDGKVVYG	EPIAASLGTD	GTHYWNKEWH	HAAHHVMGPP
LRPDPSTPDF	LMNLLANDDL	TTTGTDNCTF	NTCQKALGKD	DFTKIPNGVN
GVEDRMSVIW	EKGVHSGKMD	ENRFVAVTST	NAAKIFNLYP	RKGRIAVGSD
ADIVIWDPKG	TRTISAKTHH	QAVNFNIFEG	MVCHGVPLVT	ISRGKVVYEA
GVFSVTAGDG	KFIPRKPFAE	YIYKRIKQRD	RTCTPTPVER	APYKGEVATL
KSRVTKEDAT	AGTRKQAHP

Funkcija

Dihidropirimidinaza katalizira pretvorbu 5,6-dihidrouracila u 3-ureidopropionat u metabolizmu pirimidina. Dihidropirimidinaza se eksprimira na visokom nivou u jetri i bubrezima, kao glavni 2,5-kb transkript i manji 3,8-kb transkript. Defekti gena DPYS povezani su sa dihidropirimidinurijom.^[6]

Mapa interaktivnog puta

Šablon:FluoropyrimidineActivity WP1601

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147647 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022304 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
^ ^a ^b "Entrez Gene: DPYS dihydropyrimidinase".
^ "UniProt, Q14117" (jezik: engleski). Pristupljeno 16. 9. 2021.

Dopunska literatura

Thomas HR, Ezzeldin HH, Guarcello V, et al. (2008). "Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism". Pharmacogenet. Genomics. 18 (1): 25–35. doi:10.1097/FPC.0b013e3282f2f134. PMID 18216719. S2CID 10940058.
Thomas HR, Ezzeldin HH, Guarcello V, et al. (2008). "Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism". Pharmacogenet. Genomics. 17 (11): 973–87. doi:10.1097/FPC.0b013e3282f01788. PMID 18075467. S2CID 23490646.
van Kuilenburg AB, Meijer J, Dobritzsch D, et al. (2007). "Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency". Mol. Genet. Metab. 91 (2): 157–64. doi:10.1016/j.ymgme.2007.02.008. PMID 17383919.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
Hamajima N, Kouwaki M, Vreken P, et al. (1998). "Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene". Am. J. Hum. Genet. 63 (3): 717–26. doi:10.1086/302022. PMC 1377410. PMID 9718352.
Naguib FN, el Kouni MH, Cha S (1985). "Enzymes of uracil catabolism in normal and neoplastic human tissues". Cancer Res. 45 (11 Pt 1): 5405–12. PMID 3931905.

Vanjski linkovi

Šablon:Enzimi nukleotidnog metabolizma

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147647 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022304 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8973361-5] Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.

[entrez-6] "Entrez Gene: DPYS dihydropyrimidinase".

[UniProt-7] "UniProt, Q14117" (jezik: engleski). Pristupljeno 16. 9. 2021.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak