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Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

Nature Genetics volume 11, pages 241–247 (1995)Cite this article

Abstract

Genetic studies are under way for many complex traits, spurred by the recent feasibility of whole genome scans. Clear guidelines for the interpretation of linkage results are needed to avoid a flood of false positive claims. At the same time, an overly cautious approach runs the risk of causing true hints of linkage to be missed. We address this problem by proposing specific standards designed to maintain rigor while also promoting communication.

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Authors and Affiliations

  1. Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts, 02142, USA

    Eric Lander & Leonid Kruglyak

  2. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Eric Lander

Authors
  1. Eric Lander
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  2. Leonid Kruglyak
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Lander, E., Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11, 241–247 (1995). https://doi.org/10.1038/ng1195-241

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