Factor de crecemento placentario
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| PDB 1rv6 | |
Factor de crecemento placentrio
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| Identificadores | |
| Símbolo | PGF |
| Símbolos alt. | PGF ; D12S1900; PGFL; PLGF; PlGF-2; SHGC-10760 |
| Entrez | 5228 |
| OMIM | |
| RefSeq | NP_001193941 |
| UniProt | P49763 |
| Outros datos | |
| Locus | Cr. 14 :(74.94 – 74.96 Mb) |
O factor de crecemento placentario ou PGF (do inglés Placental Growth Factor) é unha proteína que nos humanos está codificada polo xene PGF do cromosoma 14.[1][2]
O PGF é membro da subfamilia do factor de crecemento endotelial vascular (VEGF), a cal é unha molécula clave na anxioxénese e vasculoxénese, en especial durante a embrioxénese. A principal fonte de PGF durante o embarazo é o trofoblasto placentario. O PGF exprésase tamén en moitos outros tecidos, incluíndo o trofoblasto viloso.[3]
Importancia clínica
[editar | editar a fonte]A expresión do factor de crecemento placentario nas lesións ateroscleróticas humanas está asociado con placas de inflamación e crecemento neovascular.[4][5]
Os niveis séricos de PGF e sFlt-1 (tirosina quinase-1 de tipo fms soluble, tamén chamado receptor-1 soluble do VEGF) están alterados en mulleres con preeclampsia. Tanto na preeclampsia temperá coma na tardía, os niveis no soro materno de sFlt-1 son maiores e os do PGF son máis baixos en mulleres que presentan preeclampsia. Ademais, os niveis de sFlt-1 placentarios estaban incrementados significativamente e o PGF estaba diminuído en mulleres con preeclampsia ao comparalas con outras con embarazos sen complicacións. Isto indica que as concentracións placentarias de sFlt-1 e PGF reflicten os cambios no soro materno. Isto é consistente coa idea de que a placenta é a principal fonte de sFlt-1 e PGF durante o embarazo.
Notas
[editar | editar a fonte]- ↑ "Entrez Gene: PGF placental growth factor, vascular endothelial growth factor-related protein".
- ↑ Maglione D, Guerriero V, Viglietto G, Ferraro MG, Aprelikova O, Alitalo K, Del Vecchio S, Lei KJ, Chou JY, Persico MG (April 1993). "Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14". Oncogene 8 (4): 925–31. PMID 7681160.
- ↑ Khalil A, Muttukrishna S, Harrington K, Jauniaux E (2008). Lumbiganon, Pisake, ed. "Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders". PLoS ONE 3 (7): e2766. PMC 2447877. PMID 18648513. doi:10.1371/journal.pone.0002766.
- ↑ Khurana R, Moons L, Shafi S, Luttun A, Collen D, Martin JF, Carmeliet P, Zachary IC (May 2005). "Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation". Circulation 111 (21): 2828–2836. PMID 15911697. doi:10.1161/CIRCULATIONAHA.104.495887.
- ↑ Shibuya M (April 2008). "Vascular endothelial growth factor-dependent and -independent regulation of angiogenesis". BMB Rep 41 (4): 278–86. PMID 18452647. doi:10.5483/BMBRep.2008.41.4.278. Arquivado dende o orixinal o 25 de xullo de 2011. Consultado o 07 de agosto de 2015.
Véxase tamén
[editar | editar a fonte]Bibliografía
[editar | editar a fonte]- Luttun A, Tjwa M, Carmeliet P (2003). "Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders". Ann. N. Y. Acad. Sci. 979: 80–93. PMID 12543719. doi:10.1111/j.1749-6632.2002.tb04870.x.
- Maglione D, Guerriero V, Viglietto G, et al. (1991). "Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9267–9271. PMC 52695. PMID 1924389. doi:10.1073/pnas.88.20.9267.
- Maglione D, Guerriero V, Viglietto G, et al. (1993). "Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14". Oncogene 8 (4): 925–31. PMID 7681160.
- Park JE, Chen HH, Winer J, et al. (1994). "Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR". J. Biol. Chem. 269 (41): 25646–54. PMID 7929268.
- Hauser S, Weich HA (1994). "A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta". Growth Factors 9 (4): 259–268. PMID 8148155. doi:10.3109/08977199308991586.
- Mattei MG, Borg JP, Rosnet O, et al. (1996). "Assignment of vascular endothelial growth factor (VEGF) and placenta growth factor (PLGF) genes to human chromosome 6p12-p21 and 14q24-q31 regions, respectively". Genomics 32 (1): 168–169. PMID 8786112. doi:10.1006/geno.1996.0098.
- Ziche M, Maglione D, Ribatti D, et al. (1997). "Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic". Lab. Invest. 76 (4): 517–31. PMID 9111514.
- Vuorela P, Hatva E, Lymboussaki A, et al. (1997). "Expression of vascular endothelial growth factor and placenta growth factor in human placenta". Biol. Reprod. 56 (2): 489–494. PMID 9116151. doi:10.1095/biolreprod56.2.489.
- Cao Y, Ji WR, Qi P, et al. (1997). "Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing". Biochem. Biophys. Res. Commun. 235 (3): 493–498. PMID 9207183. doi:10.1006/bbrc.1997.6813.
- Davis-Smyth T, Presta LG, Ferrara N (1998). "Mapping the charged residues in the second immunoglobulin-like domain of the vascular endothelial growth factor/placenta growth factor receptor Flt-1 required for binding and structural stability". J. Biol. Chem. 273 (6): 3216–3222. PMID 9452434. doi:10.1074/jbc.273.6.3216.
- Landgren E, Schiller P, Cao Y, Claesson-Welsh L (1998). "Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1". Oncogene 16 (3): 359–367. PMID 9467961. doi:10.1038/sj.onc.1201545.
- Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]". J. Biol. Chem. 275 (24): 18040–18045. PMID 10748121. doi:10.1074/jbc.M909259199.
- Renedo M, Arce I, Montgomery K, et al. (2000). "A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2". Genomics 65 (2): 129–136. PMID 10783260. doi:10.1006/geno.2000.6163.
- Maglione D, Battisti M, Tucci M (2000). "Recombinant production of PIGF-1 and its activity in animal models". Farmaco 55 (3): 165–167. PMID 10919072. doi:10.1016/S0014-827X(00)00012-4.
- Roberts-Clark DJ, Smith AJ (2000). "Angiogenic growth factors in human dentine matrix". Arch. Oral Biol. 45 (11): 1013–1016. PMID 11000388. doi:10.1016/S0003-9969(00)00075-3.
- Iyer S, Leonidas DD, Swaminathan GJ, et al. (2001). "The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution". J. Biol. Chem. 276 (15): 12153–12161. PMID 11069911. doi:10.1074/jbc.M008055200.
- Li XF, Charnock-Jones DS, Zhang E, et al. (2001). "Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells". J. Clin. Endocrinol. Metab. 86 (4): 1823–1834. PMID 11297624. doi:10.1210/jc.86.4.1823.
- Su YN, Hsu JJ, Lee CN, et al. (2002). "Raised maternal serum placenta growth factor concentration during the second trimester is associated with Down syndrome". Prenat. Diagn. 22 (1): 8–12. PMID 11810642. doi:10.1002/pd.218.
- Angelucci C, Lama G, Iacopino F, et al. (2002). "Effect of placenta growth factor-1 on proliferation and release of nitric oxide, cyclic AMP and cyclic GMP in human epithelial cells expressing the FLT-1 receptor". Growth Factors 19 (3): 193–206. PMID 11811792. doi:10.3109/08977190109001086.
- Mamluk R, Gechtman Z, Kutcher ME, et al. (2002). "Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain". J. Biol. Chem. 277 (27): 24818–24825. PMID 11986311. doi:10.1074/jbc.M200730200.
