Oral drug delivery system becomes challenging when the drug product needs to be delivered in modi... more Oral drug delivery system becomes challenging when the drug product needs to be delivered in modified release pattern in especially since it is difficult to swallow for them. Compaction of multiparticulates, commonly called Multiple Unit Pellet System (MUPS), is one of the more recent and challenging technologies that combine the advantages of both tablets and pellet-filled capsules in one dosage form. This article reviews the advantages and drawbacks of multiple unit pellet system, properties of an ideal multiple unit pellet system dosage form, mechanisms involved in their compaction, their disintegration and dissolution behaviour, objectives/rationale involved in the design of dosage form, challenges in their compaction and key variables to be considered in successful production of multiple unit pellet system. Compressed multi-particulate system prepared by using pellets have several pharmacokinetic, pharmacodynamic, commercial and other advantages as mentioned henceforth in this ...
Beni-Suef University Journal of Basic and Applied Sciences
Background The colon has a significant site to deliver numerous active materials for colonic dise... more Background The colon has a significant site to deliver numerous active materials for colonic diseases. Highly biodegradable polymers hold significant promise among the several techniques available to deliver the drug to the colon. This research aimed to prepare chitosan, locust bean gum and xanthan gum polysaccharide composite satranidazole multiunit pellets for colonic release and assesses the bioavailability with pharmacokinetic parameters after administration of satranidazole raw drug compared to multiunit pellets. Satranidazole multiple unit pellets were prepared based on chitosan, locust bean gum and xanthan gum, which were inexpensive and harmless. The bioavailability study was done by crossover design in which satranidazole raw drug and test formulation was administered to six healthy white albino rats. Results The pharmacokinetic analyses were estimated using the deconvolution of the plasma profile. Compared to the satranidazole drug used as a reference, for the pellets, the...
Oral drug delivery system becomes challenging when the drug product needs to be delivered in modi... more Oral drug delivery system becomes challenging when the drug product needs to be delivered in modified release pattern in especially since it is difficult to swallow for them. Compaction of multiparticulates, commonly called Multiple Unit Pellet System (MUPS), is one of the more recent and challenging technologies that combine the advantages of both tablets and pellet-filled capsules in one dosage form. This article reviews the advantages and drawbacks of multiple unit pellet system, properties of an ideal multiple unit pellet system dosage form, mechanisms involved in their compaction, their disintegration and dissolution behaviour, objectives/rationale involved in the design of dosage form, challenges in their compaction and key variables to be considered in successful production of multiple unit pellet system. Compressed multi-particulate system prepared by using pellets have several pharmacokinetic, pharmacodynamic, commercial and other advantages as mentioned henceforth in this ...
The film of miracle herbal polymer, Moringa Oleifera was prepared along with 30% and 50% of plast... more The film of miracle herbal polymer, Moringa Oleifera was prepared along with 30% and 50% of plasticizers like propylene glycol, PEG-4000 and glycerol to ensure the spreading and/or the film forming capability of the herbal polymer. In this study, three plasticizers, namely polyethylene glycol 4000, propylene glycol and glycerol were selected and the aqueous film coating solution was prepared by incorporating different concentrations of the plasticizers. The evaluatory parameters of the prepared cast film of Moringa Oleifera like thickness, folding endurance, tensile strength, moisture loss, water uptake and vapour-pressure transmission rate were evaluated and the folding endurance value of the prepared films (F2, F6) was found satisfactory which ensures that the films prepared using the herbal polymer Moringa oleifera were having optimum flexibility and were no brittle. The percent moisture content (% W/W) of the film prepared with different proportion of glycerol and polyethylene glycol-4000 were found to be in between 3.2 to 3.5 (% W/W). It was observed that with increase in hydrophilic polymer concentration, the moisture content was also increasing. The water uptake (% W/W) of the film of the herbal polymer, Moringa Oleifera were found in between 4.1 to 4.4 (% W/W). In water uptake study, it was observed that the water uptake value increases with gradual increase in concentration of hydrophilic polymer. The water-vapour transmission rate through different film formulations showed that the films were permeable to water and the films showed uniform flatness without any observed constriction.
Rimonabant is an antiobesity drug which is CB1 cannabinoid receptor antagonist. Its main avenue o... more Rimonabant is an antiobesity drug which is CB1 cannabinoid receptor antagonist. Its main avenue of effect is reduction in appetite. So far only HPLC methods of analysis exist for the routine examination of drug. An attempt is hereby made to develop a simple ...
Indian Research Journal of Pharmacy and Science, 2019
Protein based nanoparticles are investigated size, container-like shape, natural source, biocompa... more Protein based nanoparticles are investigated size, container-like shape, natural source, biocompatibility, and biodegradability. range in size from about 1-1000 nanometers in diameter, about one thousand in a human body. These are made up by a variety of materials including metals, polysaccharides, and proteins which having biodegradability, bioavailability, and relatively low cost in nature. protein nanoparticles are e to process and can be modified by desired flexible fabrication, and high surface Nanoparticles can be made from a var Biological protein-based nanoparticles such as silk, keratin, collagen, elastin, corn zein, and soy protein nanoparticles are advantageous in having biodegradability, bioavailability, of protein based nanoparticles has recently use protein like albumin, gelatine. The techniques for their fabrication include emulsification, de coacervation, and electro-spray. The administration are explored and reported by the protein nanoparticles as drug delivery carriers.
Protein based nanoparticles are investigated size, container-like shape, natural source, biocompa... more Protein based nanoparticles are investigated size, container-like shape, natural source, biocompatibility, and biodegradability. range in size from about 1-1000 nanometers in diameter, about one thousand in a human body. These are made up by a variety of materials including metals, polysaccharides, and proteins which having biodegradability, bioavailability, and relatively low cost in nature. protein nanoparticles are e to process and can be modified by desired flexible fabrication, and high surface Nanoparticles can be made from a var Biological protein-based nanoparticles such as silk, keratin, collagen, elastin, corn zein, and soy protein nanoparticles are advantageous in having biodegradability, bioavailability, of protein based nanoparticles has recently use protein like albumin, gelatine. The techniques for their fabrication include emulsification, de coacervation, and electro-spray. The administration are explored and reported by the protein nanoparticles as drug delivery carriers.
Asian Journal of Pharmaceutical and Clinical Research
Objective: The major objective of the present investigation was to extract a natural polymer (okr... more Objective: The major objective of the present investigation was to extract a natural polymer (okra gum) with its characterization as pharmaceutical binder and to formulate, develop, and evaluate the compression-coated tablet using okra as binder along with synthetic hydrophilic polymers like various grades of hydroxypropyl methylcellulose (HPMC).Methods: A novel extraction method was carried out using fresh unripe pods of okra (ladies finger) with the aid of organic solvents and its characterization was done. The core tablets were prepared by direct compression method which was compression coated with okra gum and HPMC.Results: After the extraction of the okra gum was carried out, the yield of mucilage obtained was 10%. It is considered as a proof for the purity of the mucilage extract. The above study reveals that the polymers were subjected to the Fourier transform infrared and differential scanning calorimetry thermogram had no significant interactions between the drug and the po...
Asian Journal of Pharmaceutical and Clinical Research
Objective: The major objective of the present investigation was to extract a natural polymer (okr... more Objective: The major objective of the present investigation was to extract a natural polymer (okra gum) with its characterization as pharmaceutical binder and to formulate, develop, and evaluate the compression-coated tablet using okra as binder along with synthetic hydrophilic polymers like various grades of hydroxypropyl methylcellulose (HPMC).Methods: A novel extraction method was carried out using fresh unripe pods of okra (ladies finger) with the aid of organic solvents and its characterization was done. The core tablets were prepared by direct compression method which was compression coated with okra gum and HPMC.Results: After the extraction of the okra gum was carried out, the yield of mucilage obtained was 10%. It is considered as a proof for the purity of the mucilage extract. The above study reveals that the polymers were subjected to the Fourier transform infrared and differential scanning calorimetry thermogram had no significant interactions between the drug and the po...
The present study was aimed to develop and evaluate different polymeric microspheres for colon-sp... more The present study was aimed to develop and evaluate different polymeric microspheres for colon-specific delivery of Metronidazole for better treatment of colonic diseases. Different approaches for colon-specific drug delivery have been studied over the last decade, including pro-drugs, polymeric coating using pH sensitive or bacterial degradable polymers and matrices. In this research work we present colon-specific ethyl cellulose microspheres to deliver active molecules to the colonic region, which combine pH-dependent and controlled release properties. Microspheres were prepared by modified Novel Quasiemulsification solvent-diffusion method to study the effect of ethyl cellulose on drug release with different proportions of metronidazole and ethyl cellulose. Prepared microspheres of ethyl cellulose were evaluated for size, morphology, sphericity study, percentage yield, loose surface crystal study, drug content and entrapment efficiency. In vitro drug release study was conducted b...
Background The purpose of the present study was to evaluate layered of satranidazole powder using... more Background The purpose of the present study was to evaluate layered of satranidazole powder using natural polysaccharides as coating materials for colon targeting that were inexpensive and natural with a non-toxic nature using a composite response design of 3 levels and 2 factors for each of the four responses in the quadratic model. The independent variables were the ratio of coating consistency % (X1) and coating level % (X2) in the pellet. The dependent factors were % release of drug at 2 h. (Y1), % release of drug at 6 h. (Y2), % release of drug difference in presence & absence of colonic enzyme (Y3) and mean dissolution time (Y4). The various models were fitted for the responses with an explanation of suitable statistical methods. Variance analysis and different factor levels of responses were constructed by response surface plots. Results Satranidazole pellets were efficiently prepared by the variable amount of ingredients that showed compatibility with possible pellet charact...
:: The explanations behind a wide spreadability of coronavirus sickness (COVID-19) are not known ... more :: The explanations behind a wide spreadability of coronavirus sickness (COVID-19) are not known properly in this world. Several clinical investigations have indicated that the BCG antibody has impacts on the immune system and human sicknesses which takes a part in the host system to such an extent that numerous types of viral diseases are extensively diminished or reduced. Subsequently, it was also observed in different studies that the recurrence and seriousness of numerous microbial or viral diseases including COVID-19 will be lower in few countries where BCG Immunization programs are carried out. Few clinical investigations proposed by the epidemiological shown that BCG antibody have effect on building valuable impact in COVID-19. So the BCG immunization may be found valuable in the coming months particularly in the countries where mass BCG immunization done. Further thorough BCG immunization clinical trial is required to establish the above findings and its clinical significant. In future this investigation will concentrate on the BCG vaccine and it may forestall the event of SARS-CoV-2 contamination and its succession in the large population.
Background The aim of the present investigation was to improve comprehensive analytical method fo... more Background The aim of the present investigation was to improve comprehensive analytical method for the assessment of satranidazole in drug and product with simple, economic, sensitive, and reproducible spectrophotometric method. The drug was analyzed in three different methods by using various solvents where satranidazole (STZ) showed different absorbance maxima (s) and sharp peaks in the first order derivative spectra. Beer’s law range, correlation coefficient, apparent molar absorptivity, etc., were determined for each solvent using all the three methods. Results All the results of analysis were found to be satisfactory which was validated statistically for various parameters and by performing recovery studies in accordance with international conference on harmonization (ICH) guidelines. The developed methods were also compared statistically using one way analysis of variance (ANOVA). Conclusion Three different spectrophotometric methods were developed for satranidazole (STZ) usin...
Oral drug delivery system becomes challenging when the drug product needs to be delivered in modi... more Oral drug delivery system becomes challenging when the drug product needs to be delivered in modified release pattern in especially since it is difficult to swallow for them. Compaction of multiparticulates, commonly called Multiple Unit Pellet System (MUPS), is one of the more recent and challenging technologies that combine the advantages of both tablets and pellet-filled capsules in one dosage form. This article reviews the advantages and drawbacks of multiple unit pellet system, properties of an ideal multiple unit pellet system dosage form, mechanisms involved in their compaction, their disintegration and dissolution behaviour, objectives/rationale involved in the design of dosage form, challenges in their compaction and key variables to be considered in successful production of multiple unit pellet system. Compressed multi-particulate system prepared by using pellets have several pharmacokinetic, pharmacodynamic, commercial and other advantages as mentioned henceforth in this ...
Beni-Suef University Journal of Basic and Applied Sciences
Background The colon has a significant site to deliver numerous active materials for colonic dise... more Background The colon has a significant site to deliver numerous active materials for colonic diseases. Highly biodegradable polymers hold significant promise among the several techniques available to deliver the drug to the colon. This research aimed to prepare chitosan, locust bean gum and xanthan gum polysaccharide composite satranidazole multiunit pellets for colonic release and assesses the bioavailability with pharmacokinetic parameters after administration of satranidazole raw drug compared to multiunit pellets. Satranidazole multiple unit pellets were prepared based on chitosan, locust bean gum and xanthan gum, which were inexpensive and harmless. The bioavailability study was done by crossover design in which satranidazole raw drug and test formulation was administered to six healthy white albino rats. Results The pharmacokinetic analyses were estimated using the deconvolution of the plasma profile. Compared to the satranidazole drug used as a reference, for the pellets, the...
Oral drug delivery system becomes challenging when the drug product needs to be delivered in modi... more Oral drug delivery system becomes challenging when the drug product needs to be delivered in modified release pattern in especially since it is difficult to swallow for them. Compaction of multiparticulates, commonly called Multiple Unit Pellet System (MUPS), is one of the more recent and challenging technologies that combine the advantages of both tablets and pellet-filled capsules in one dosage form. This article reviews the advantages and drawbacks of multiple unit pellet system, properties of an ideal multiple unit pellet system dosage form, mechanisms involved in their compaction, their disintegration and dissolution behaviour, objectives/rationale involved in the design of dosage form, challenges in their compaction and key variables to be considered in successful production of multiple unit pellet system. Compressed multi-particulate system prepared by using pellets have several pharmacokinetic, pharmacodynamic, commercial and other advantages as mentioned henceforth in this ...
The film of miracle herbal polymer, Moringa Oleifera was prepared along with 30% and 50% of plast... more The film of miracle herbal polymer, Moringa Oleifera was prepared along with 30% and 50% of plasticizers like propylene glycol, PEG-4000 and glycerol to ensure the spreading and/or the film forming capability of the herbal polymer. In this study, three plasticizers, namely polyethylene glycol 4000, propylene glycol and glycerol were selected and the aqueous film coating solution was prepared by incorporating different concentrations of the plasticizers. The evaluatory parameters of the prepared cast film of Moringa Oleifera like thickness, folding endurance, tensile strength, moisture loss, water uptake and vapour-pressure transmission rate were evaluated and the folding endurance value of the prepared films (F2, F6) was found satisfactory which ensures that the films prepared using the herbal polymer Moringa oleifera were having optimum flexibility and were no brittle. The percent moisture content (% W/W) of the film prepared with different proportion of glycerol and polyethylene glycol-4000 were found to be in between 3.2 to 3.5 (% W/W). It was observed that with increase in hydrophilic polymer concentration, the moisture content was also increasing. The water uptake (% W/W) of the film of the herbal polymer, Moringa Oleifera were found in between 4.1 to 4.4 (% W/W). In water uptake study, it was observed that the water uptake value increases with gradual increase in concentration of hydrophilic polymer. The water-vapour transmission rate through different film formulations showed that the films were permeable to water and the films showed uniform flatness without any observed constriction.
Rimonabant is an antiobesity drug which is CB1 cannabinoid receptor antagonist. Its main avenue o... more Rimonabant is an antiobesity drug which is CB1 cannabinoid receptor antagonist. Its main avenue of effect is reduction in appetite. So far only HPLC methods of analysis exist for the routine examination of drug. An attempt is hereby made to develop a simple ...
Indian Research Journal of Pharmacy and Science, 2019
Protein based nanoparticles are investigated size, container-like shape, natural source, biocompa... more Protein based nanoparticles are investigated size, container-like shape, natural source, biocompatibility, and biodegradability. range in size from about 1-1000 nanometers in diameter, about one thousand in a human body. These are made up by a variety of materials including metals, polysaccharides, and proteins which having biodegradability, bioavailability, and relatively low cost in nature. protein nanoparticles are e to process and can be modified by desired flexible fabrication, and high surface Nanoparticles can be made from a var Biological protein-based nanoparticles such as silk, keratin, collagen, elastin, corn zein, and soy protein nanoparticles are advantageous in having biodegradability, bioavailability, of protein based nanoparticles has recently use protein like albumin, gelatine. The techniques for their fabrication include emulsification, de coacervation, and electro-spray. The administration are explored and reported by the protein nanoparticles as drug delivery carriers.
Protein based nanoparticles are investigated size, container-like shape, natural source, biocompa... more Protein based nanoparticles are investigated size, container-like shape, natural source, biocompatibility, and biodegradability. range in size from about 1-1000 nanometers in diameter, about one thousand in a human body. These are made up by a variety of materials including metals, polysaccharides, and proteins which having biodegradability, bioavailability, and relatively low cost in nature. protein nanoparticles are e to process and can be modified by desired flexible fabrication, and high surface Nanoparticles can be made from a var Biological protein-based nanoparticles such as silk, keratin, collagen, elastin, corn zein, and soy protein nanoparticles are advantageous in having biodegradability, bioavailability, of protein based nanoparticles has recently use protein like albumin, gelatine. The techniques for their fabrication include emulsification, de coacervation, and electro-spray. The administration are explored and reported by the protein nanoparticles as drug delivery carriers.
Asian Journal of Pharmaceutical and Clinical Research
Objective: The major objective of the present investigation was to extract a natural polymer (okr... more Objective: The major objective of the present investigation was to extract a natural polymer (okra gum) with its characterization as pharmaceutical binder and to formulate, develop, and evaluate the compression-coated tablet using okra as binder along with synthetic hydrophilic polymers like various grades of hydroxypropyl methylcellulose (HPMC).Methods: A novel extraction method was carried out using fresh unripe pods of okra (ladies finger) with the aid of organic solvents and its characterization was done. The core tablets were prepared by direct compression method which was compression coated with okra gum and HPMC.Results: After the extraction of the okra gum was carried out, the yield of mucilage obtained was 10%. It is considered as a proof for the purity of the mucilage extract. The above study reveals that the polymers were subjected to the Fourier transform infrared and differential scanning calorimetry thermogram had no significant interactions between the drug and the po...
Asian Journal of Pharmaceutical and Clinical Research
Objective: The major objective of the present investigation was to extract a natural polymer (okr... more Objective: The major objective of the present investigation was to extract a natural polymer (okra gum) with its characterization as pharmaceutical binder and to formulate, develop, and evaluate the compression-coated tablet using okra as binder along with synthetic hydrophilic polymers like various grades of hydroxypropyl methylcellulose (HPMC).Methods: A novel extraction method was carried out using fresh unripe pods of okra (ladies finger) with the aid of organic solvents and its characterization was done. The core tablets were prepared by direct compression method which was compression coated with okra gum and HPMC.Results: After the extraction of the okra gum was carried out, the yield of mucilage obtained was 10%. It is considered as a proof for the purity of the mucilage extract. The above study reveals that the polymers were subjected to the Fourier transform infrared and differential scanning calorimetry thermogram had no significant interactions between the drug and the po...
The present study was aimed to develop and evaluate different polymeric microspheres for colon-sp... more The present study was aimed to develop and evaluate different polymeric microspheres for colon-specific delivery of Metronidazole for better treatment of colonic diseases. Different approaches for colon-specific drug delivery have been studied over the last decade, including pro-drugs, polymeric coating using pH sensitive or bacterial degradable polymers and matrices. In this research work we present colon-specific ethyl cellulose microspheres to deliver active molecules to the colonic region, which combine pH-dependent and controlled release properties. Microspheres were prepared by modified Novel Quasiemulsification solvent-diffusion method to study the effect of ethyl cellulose on drug release with different proportions of metronidazole and ethyl cellulose. Prepared microspheres of ethyl cellulose were evaluated for size, morphology, sphericity study, percentage yield, loose surface crystal study, drug content and entrapment efficiency. In vitro drug release study was conducted b...
Background The purpose of the present study was to evaluate layered of satranidazole powder using... more Background The purpose of the present study was to evaluate layered of satranidazole powder using natural polysaccharides as coating materials for colon targeting that were inexpensive and natural with a non-toxic nature using a composite response design of 3 levels and 2 factors for each of the four responses in the quadratic model. The independent variables were the ratio of coating consistency % (X1) and coating level % (X2) in the pellet. The dependent factors were % release of drug at 2 h. (Y1), % release of drug at 6 h. (Y2), % release of drug difference in presence & absence of colonic enzyme (Y3) and mean dissolution time (Y4). The various models were fitted for the responses with an explanation of suitable statistical methods. Variance analysis and different factor levels of responses were constructed by response surface plots. Results Satranidazole pellets were efficiently prepared by the variable amount of ingredients that showed compatibility with possible pellet charact...
:: The explanations behind a wide spreadability of coronavirus sickness (COVID-19) are not known ... more :: The explanations behind a wide spreadability of coronavirus sickness (COVID-19) are not known properly in this world. Several clinical investigations have indicated that the BCG antibody has impacts on the immune system and human sicknesses which takes a part in the host system to such an extent that numerous types of viral diseases are extensively diminished or reduced. Subsequently, it was also observed in different studies that the recurrence and seriousness of numerous microbial or viral diseases including COVID-19 will be lower in few countries where BCG Immunization programs are carried out. Few clinical investigations proposed by the epidemiological shown that BCG antibody have effect on building valuable impact in COVID-19. So the BCG immunization may be found valuable in the coming months particularly in the countries where mass BCG immunization done. Further thorough BCG immunization clinical trial is required to establish the above findings and its clinical significant. In future this investigation will concentrate on the BCG vaccine and it may forestall the event of SARS-CoV-2 contamination and its succession in the large population.
Background The aim of the present investigation was to improve comprehensive analytical method fo... more Background The aim of the present investigation was to improve comprehensive analytical method for the assessment of satranidazole in drug and product with simple, economic, sensitive, and reproducible spectrophotometric method. The drug was analyzed in three different methods by using various solvents where satranidazole (STZ) showed different absorbance maxima (s) and sharp peaks in the first order derivative spectra. Beer’s law range, correlation coefficient, apparent molar absorptivity, etc., were determined for each solvent using all the three methods. Results All the results of analysis were found to be satisfactory which was validated statistically for various parameters and by performing recovery studies in accordance with international conference on harmonization (ICH) guidelines. The developed methods were also compared statistically using one way analysis of variance (ANOVA). Conclusion Three different spectrophotometric methods were developed for satranidazole (STZ) usin...
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